Aamir Mir
Aamir Mir
Associate Director at Tessera Therapeutics
Verifisert e-postadresse på tesseratx.com
Sitert av
Sitert av
A compact, high-accuracy Cas9 with a dinucleotide PAM for in vivo genome editing
A Edraki, A Mir, R Ibraheim, I Gainetdinov, Y Yoon, CQ Song, Y Cao, ...
Molecular cell 73 (4), 714-726. e4, 2019
Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice
P Liu, SQ Liang, C Zheng, E Mintzer, YG Zhao, K Ponnienselvan, A Mir, ...
Nature communications 12 (1), 2121, 2021
Type II-C CRISPR-Cas9 biology, mechanism, and application
A Mir, A Edraki, J Lee, EJ Sontheimer
ACS chemical biology 13 (2), 357-365, 2018
NmeCas9 is an intrinsically high-fidelity genome-editing platform
N Amrani, XD Gao, P Liu, A Edraki, A Mir, R Ibraheim, A Gupta, KE Sasaki, ...
Genome Biology 19 (1), 1-25, 2018
C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9–APEX2
XD Gao, LC Tu, A Mir, T Rodriguez, Y Ding, J Leszyk, J Dekker, ...
Nature methods 15 (6), 433-436, 2018
All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo
R Ibraheim, CQ Song, A Mir, N Amrani, W Xue, EJ Sontheimer
Genome Biology, 2018
Potent Cas9 inhibition in bacterial and human cells by AcrIIC4 and AcrIIC5 anti-CRISPR proteins
J Lee, A Mir, A Edraki, B Garcia, N Amrani, HE Lou, I Gainetdinov, ...
MBio 9 (6), e02321-18, 2018
Heavily and Fully Modified RNAs Guide Efficient SpyCas9-Mediated Genome Editing
A Mir, JF Alterman, MR Hassler, AJ Debacker, E Hudgens, D Echeverria, ...
Nature Communications, 2018
Two active site divalent ions in the crystal structure of the hammerhead ribozyme bound to a transition state analogue
A Mir, BL Golden
Biochemistry 55 (4), 633-636, 2016
Two divalent metal ions and conformational changes play roles in the hammerhead ribozyme cleavage reaction
A Mir, J Chen, K Robinson, E Lendy, J Goodman, D Neau, BL Golden
Biochemistry 54 (41), 6369-6381, 2015
Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo
R Ibraheim, PWL Tai, A Mir, N Javeed, J Wang, TC Rodríguez, ...
Nature communications 12 (1), 6267, 2021
Nucleic acid-guided nucleases
J Kim, B Mijts, A Mir, A Garst, K Seamon
US Patent 10,745,678, 2020
Nucleic acid-guided nucleases
J Kim, B Mijts, A Mir, A Garst, K Seamon
US Patent 10,724,021, 2020
Nucleic acid-guided nucleases
J Kim, B Mijts, A Mir, A Garst, K Seamon
US Patent 10,704,033, 2020
Anti-CRISPR AcrIIA5 potently inhibits all Cas9 homologs used for genome editing
B Garcia, J Lee, A Edraki, Y Hidalgo-Reyes, S Erwood, A Mir, CN Trost, ...
Cell reports 29 (7), 1739-1746. e5, 2019
5′ Modifications Improve Potency and Efficacy of DNA Donors for Precision Genome Editing 2
KS Ghanta, GA Dokshin, A Mir, PM Krishnamurthy
Nucleic acid-guided nucleases
J Kim, B Mijts, A Mir, A Garst, K Seamon
US Patent 10,767,169, 2020
Automated multi-module cell processing methods, instruments, and systems
E Feldman, B Mijts, A Mir, E Zimmerman, A Garst
US Patent 10,689,669, 2020
Efficient homology-directed repair with circular ssDNA donors
S Iyer, A Mir, J Vega-Badillo, BP Roscoe, R Ibraheim, LJ Zhu, J Lee, P Liu, ...
bioRxiv, 864199, 2019
Engineered enzymes
B Mijts, J Kim, A Mir, K Seamon, A Garst
US Patent 10,655,114, 2020
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