Rune Kleppe
Rune Kleppe
Researcher, Helse Bergen
Verifisert e-postadresse på
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Sitert av
The 14-3-3 proteins in regulation of cellular metabolism
R Kleppe, A Martinez, SO Døskeland, J Haavik
Seminars in cell & developmental biology 22 (7), 713-719, 2011
Regulation of tyrosine hydroxylase by stress‐activated protein kinases
K Toska, R Kleppe, CG Armstrong, NA Morrice, P Cohen, J Haavik
Journal of neurochemistry 83 (4), 775-783, 2002
Interaction of phosphorylated tyrosine hydroxylase with 14‐3‐3 proteins: evidence for a phosphoserine 40‐dependent association
R Kleppe, K Toska, J Haavik
Journal of neurochemistry 77 (4), 1097-1107, 2001
Does Isoform Diversity Explain Functional Differences in the 14-3-3Protein Family?
E Kjarland, TJ Keen, R Kleppe
Current pharmaceutical biotechnology 7 (3), 217-223, 2006
Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding
I Winge, JA Mckinney, M Ying, CS D'Santos, R Kleppe, PM Knappskog, ...
Biochemical Journal 410 (1), 195-204, 2008
Three-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase, and negatively charged membranes
Ø Halskau, M Ying, A Baumann, R Kleppe, D Rodriguez-Larrea, B Almås, ...
Journal of Biological Chemistry 284 (47), 32758-32769, 2009
Functional studies of tyrosine hydroxylase missense variants reveal distinct patterns of molecular defects in dopa‐responsive dystonia
A Fossbakk, R Kleppe, PM Knappskog, A Martinez, J Haavik
Human mutation 35 (7), 880-890, 2014
Urea-induced denaturation of human phenylalanine hydroxylase
R Kleppe, K Uhlemann, PM Knappskog, J Haavik
Journal of Biological Chemistry 274 (47), 33251-33258, 1999
Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease
K Waløen, R Kleppe, A Martinez, J Haavik
Expert opinion on therapeutic targets 21 (2), 167-180, 2017
Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis
G Gausdal, A Wergeland, J Skavland, E Nguyen, F Pendino, N Rouhee, ...
Cell death & disease 4 (2), e516-e516, 2013
Nostocyclopeptide-M1: A potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and OATP1B1
L Herfindal, L Myhren, R Kleppe, C Krakstad, F Selheim, J Jokela, ...
Molecular pharmaceutics 8 (2), 360-367, 2011
Increased microvascular permeability in mice lacking Epac1 (Rapgef3)
RK Kopperud, CB Rygh, TV Karlsen, C Krakstad, R Kleppe, EA Hoivik, ...
Acta physiologica 219 (2), 441-452, 2017
Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression
I Winge, K Teigen, A Fossbakk, E Mahootchi, R Kleppe, F Sköldberg, ...
Neurochemistry international 90, 173-184, 2015
Phosphorylation dependence and stoichiometry of the complex formed by tyrosine hydroxylase and 14-3-3γ
R Kleppe, S Rosati, A Jorge-Finnigan, S Alvira, S Ghorbani, J Haavik, ...
Molecular & Cellular Proteomics 13 (8), 2017-2030, 2014
Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription
S Huseby, G Gausdal, TJ Keen, E Kjaerland, C Krakstad, L Myhren, ...
Cell death & disease 2 (12), e237-e237, 2011
Exome chip analyses in adult attention deficit hyperactivity disorder
T Zayats, KK Jacobsen, R Kleppe, CP Jacob, S Kittel-Schneider, ...
Translational psychiatry 6 (10), e923-e923, 2016
Phosphorylation of tyrosine hydroxylase in isolated mice adrenal glands
K Toska, R Kleppe, P Cohen, J Haavik
Annals of the New York Academy of Sciences 971 (1), 66-68, 2002
Epistatic and gene wide effects in YWHA and aromatic amino hydroxylase genes across ADHD and other common neuropsychiatric disorders: association with YWHAE
KK Jacobsen, R Kleppe, S Johansson, T Zayats, J Haavik
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 168 …, 2015
Regulation of tyrosine hydroxylase is preserved across different homo-and heterodimeric 14-3-3 proteins
S Ghorbani, A Fossbakk, A Jorge-Finnigan, MI Flydal, J Haavik, R Kleppe
Amino acids 48 (5), 1221-1229, 2016
The cAMP-dependent protein kinase pathway as therapeutic target-possibilities and pitfalls
R Kleppe, C Krakstad, F Selheim, R Kopperud, S Ove Doskeland
Current topics in medicinal chemistry 11 (11), 1393-1405, 2011
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