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Nathan Lawlor
Nathan Lawlor
2Seventy Bio
Verifisert e-postadresse på 2seventybio.com - Startside
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Single-cell transcriptomes identify human islet cell signatures and reveal cell-type–specific expression changes in type 2 diabetes
N Lawlor, J George, M Bolisetty, R Kursawe, L Sun, V Sivakamasundari, ...
Genome research 27 (2), 208-222, 2017
4642017
The human milk oligosaccharide 2′-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced inflammation
YY He, SB Liu, DE Kling, S Leone, NT Lawlor, Y Huang, SB Feinberg, ...
Gut 65 (1), 33-46, 2016
2872016
Human milk components modulate toll-like receptor–mediated inflammation
YY He, NT Lawlor, DS Newburg
Advances in Nutrition 7 (1), 102-111, 2016
1532016
Type 2 diabetes–associated genetic variants regulate chromatin accessibility in human islets
S Khetan, R Kursawe, A Youn, N Lawlor, A Jillette, EJ Marquez, D Ucar, ...
Diabetes 67 (11), 2466-2477, 2018
712018
Multiomic profiling identifies cis-regulatory networks underlying human pancreatic β cell identity and function
N Lawlor, EJ Marquez, P Orchard, N Narisu, MS Shamim, A Thibodeau, ...
Cell reports 26 (3), 788-801. e6, 2019
692019
Genomics of islet (dys) function and type 2 diabetes
N Lawlor, S Khetan, D Ucar, ML Stitzel
Trends in Genetics 33 (4), 244-255, 2017
692017
A common type 2 diabetes risk variant potentiates activity of an evolutionarily conserved islet stretch enhancer and increases C2CD4A and C2CD4B expression
I Kycia, BN Wolford, JR Huyghe, C Fuchsberger, S Vadlamudi, R Kursawe, ...
The American Journal of Human Genetics 102 (4), 620-635, 2018
452018
AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data
A Thibodeau, A Eroglu, CS McGinnis, N Lawlor, D Nehar-Belaid, ...
Genome biology 22, 1-19, 2021
422021
Single cell analysis of blood mononuclear cells stimulated through either LPS or anti-CD3 and anti-CD28
N Lawlor, D Nehar-Belaid, JDS Grassmann, M Stoeckius, P Smibert, ...
Frontiers in immunology 12, 636720, 2021
392021
Alpha TC1 and Beta-TC-6 genomic profiling uncovers both shared and distinct transcriptional regulatory features with their primary islet counterparts
N Lawlor, A Youn, R Kursawe, D Ucar, ML Stitzel
Scientific reports 7 (1), 11959, 2017
352017
(Epi) genomic heterogeneity of pancreatic islet function and failure in type 2 diabetes
N Lawlor, ML Stitzel
Molecular metabolism 27, S15-S24, 2019
152019
multiClust: an R-package for identifying biologically relevant clusters in cancer transcriptome profiles
N Lawlor, A Fabbri, P Guan, J George, RKM Karuturi
Cancer informatics 15, CIN. S38000, 2016
132016
Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes
J Rui, S Deng, AL Perdigoto, G Ponath, R Kursawe, N Lawlor, T Sumida, ...
Nature Communications 12 (1), 5074, 2021
122021
BiFET: sequencing Bias-free transcription factor Footprint Enrichment Test
A Youn, EJ Marquez, N Lawlor, ML Stitzel, D Ucar
Nucleic acids research 47 (2), e11-e11, 2019
122019
Detection of correlated hidden factors from single cell transcriptomes using Iteratively Adjusted-SVA (IA-SVA)
D Lee, A Cheng, N Lawlor, M Bolisetty, D Ucar
Scientific Reports 8 (1), 17040, 2018
112018
V-SVA: an R Shiny application for detecting and annotating hidden sources of variation in single-cell RNA-seq data
N Lawlor, EJ Marquez, D Lee, D Ucar
Bioinformatics 36 (11), 3582-3584, 2020
72020
Targeting ERRα promotes cytotoxic effects against acute myeloid leukemia through suppressing mitochondrial oxidative phosphorylation
W Seo, S Yoo, Y Zhong, SH Lee, SY Woo, HS Choi, M Won, T Roh, ...
Journal of Hematology & Oncology 15 (1), 156, 2022
22022
Tet2 controls β cells responses to inflammation in type 1 diabetes
J Rui, S Deng, G Ponath, R Kursawe, N Lawlor, T Sumida, ...
BioRxiv, 2020.09. 01.278028, 2020
22020
Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues
GL Pearson, EM Walker, N Lawlor, A Lietzke, V Sidarala, J Zhu, T Stromer, ...
bioRxiv, 2022.08. 02.502357, 2022
2022
175-OR: The Mitochondrial Life Cycle Determines ß-Cell Maturity through Activation of the Integrated Stress Response
G Pearson, N Lawlor, J Zhu, EM Walker, EC Reck, ML Stitzel, ...
Diabetes 70 (Supplement_1), 2021
2021
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Artikler 1–20