| An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28 DR Owen, AJ Yeo, RN Gunn, K Song, G Wadsworth, A Lewis, C Rhodes, ... Journal of Cerebral Blood Flow & Metabolism 32 (1), 1-5, 2012 | 768 | 2012 |
| Mixed-affinity binding in humans with 18-kDa translocator protein ligands DRJ Owen, RN Gunn, EA Rabiner, I Bennacef, M Fujita, WC Kreisl, ... Journal of nuclear medicine 52 (1), 24-32, 2011 | 406 | 2011 |
| Preclinical characterization of 18F-MK-6240, a promising PET tracer for in vivo quantification of human neurofibrillary tangles ED Hostetler, AM Walji, Z Zeng, P Miller, I Bennacef, C Salinas, ... Journal of nuclear medicine 57 (10), 1599-1606, 2016 | 244 | 2016 |
| Two Binding Sites for [3H]PBR28 in Human Brain: Implications for TSPO PET Imaging of Neuroinflammation DR Owen, OW Howell, SP Tang, LA Wells, I Bennacef, M Bergstrom, ... Journal of Cerebral Blood Flow & Metabolism 30 (9), 1608-1618, 2010 | 240 | 2010 |
| Discovery of 6-(Fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for … AM Walji, ED Hostetler, H Selnick, Z Zeng, P Miller, I Bennacef, C Salinas, ... Journal of medicinal chemistry 59 (10), 4778-4789, 2016 | 168 | 2016 |
| In vivo quantification of neurofibrillary tangles with [18F]MK-6240 TA Pascoal, M Shin, MS Kang, M Chamoun, D Chartrand, ... Alzheimer's research & therapy 10, 1-14, 2018 | 147 | 2018 |
| Quantification of the specific translocator protein signal of 18F-PBR111 in healthy humans: a genetic polymorphism effect on in vivo binding Q Guo, A Colasanti, DR Owen, M Onega, A Kamalakaran, I Bennacef, ... Journal of nuclear medicine 54 (11), 1915-1923, 2013 | 101 | 2013 |
| Brain imaging of Alzheimer dementia patients and elderly controls with 18F-MK-6240, a PET tracer targeting neurofibrillary tangles TG Lohith, I Bennacef, R Vandenberghe, M Vandenbulcke, CA Salinas, ... Journal of Nuclear Medicine 60 (1), 107-114, 2019 | 100 | 2019 |
| Variation in binding affinity of the novel anxiolytic XBD173 for the 18 kDa translocator protein in human brain DRJ Owen, AJM Lewis, R Reynolds, R Rupprecht, D Eser, MR Wilkins, ... Synapse 65 (3), 257-259, 2011 | 55 | 2011 |
| Functionalization through Lithiation of (S)-N-(1-Phenylpropyl)-2-phenylquinoline-4-carboxamide. Application to the Labeling with Carbon-11 of NK-3 Receptor … I Bennacef, C Perrio, MC Lasne, L Barré The Journal of Organic Chemistry 72 (6), 2161-2165, 2007 | 30 | 2007 |
| Dopamine D3 receptor antagonists: The quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies I Bennacef, CA Salinas, TA Bonasera, RN Gunn, H Audrain, S Jakobsen, ... Bioorganic & medicinal chemistry letters 19 (17), 5056-5059, 2009 | 29 | 2009 |
| cGMP production of the radiopharmaceutical [18F] MK‐6240 for PET imaging of human neurofibrillary tangles TL Collier, DL Yokell, E Livni, PA Rice, S Celen, K Serdons, ... Journal of Labelled Compounds and Radiopharmaceuticals 60 (5), 263-269, 2017 | 28 | 2017 |
| Palladium‐mediated oxidative carbonylation reactions for the synthesis of 11C‐radiolabelled ureas S Kealey, SM Husbands, I Bennacef, AD Gee, J Passchier Journal of Labelled Compounds and Radiopharmaceuticals 57 (4), 202-208, 2014 | 27 | 2014 |
| Preclinical Safety Evaluation and Human Dosimetry of [18F]MK-6240, a Novel PET Tracer for Imaging Neurofibrillary Tangles M Koole, TG Lohith, JL Valentine, I Bennacef, R Declercq, T Reynders, ... Molecular imaging and biology 22, 173-180, 2020 | 23 | 2020 |
| Synthesis and biological evaluation of novel fluoro and iodo quinoline carboxamides as potential ligands of NK-3 receptors for in vivo imaging studies I Bennacef, S Tymciu, M Dhilly, MC Lasne, D Debruyne, C Perrio, L Barré Bioorganic & medicinal chemistry 12 (16), 4533-4541, 2004 | 23 | 2004 |
| Test–retest characteristic of [18F]MK-6240 quantitative outcomes in cognitively normal adults and subjects with Alzheimer’s disease C Salinas, TG Lohith, A Purohit, A Struyk, C Sur, I Bennacef, J Beaver, ... Journal of Cerebral Blood Flow & Metabolism 40 (11), 2179-2187, 2020 | 22 | 2020 |
| PET/CT Imaging of 89Zr-N-sucDf-Pembrolizumab in Healthy Cynomolgus Monkeys W Li, Y Wang, D Rubins, I Bennacef, M Holahan, H Haley, M Purcell, ... Molecular Imaging and Biology 23, 250-259, 2021 | 21 | 2021 |
| Comparison of [11C] PBR28 and [18F] FEPPA as CNS peripheral benzodiazepine receptor PET ligands in the pig I Bennacef, C Salinas, G Horvath, R Gunn, T Bonasera, A Wilson, A Gee, ... Journal of Nuclear Medicine 49 (supplement 1), 81P-81P, 2008 | 20 | 2008 |
| Synthesis and receptor binding studies of halogenated N, N-dialkylel-(2-phenyl-1H-indol-3-yl) glyoxylamides to visualize peripheral benzodiazepine receptors with SPECT or PET I Bennacef, CN Haile, A Schmidt, AO Koren, JP Seibyl, JK Staley, F Bois, ... Bioorganic & medicinal chemistry 14 (22), 7582-7591, 2006 | 20 | 2006 |
| Monoamine transporter occupancy of a novel triple reuptake inhibitor in baboons and humans using positron emission tomography RA Comley, CA Salinas, M Slifstein, M Petrone, C Marzano, I Bennacef, ... Journal of Pharmacology and Experimental Therapeutics 346 (2), 311-317, 2013 | 18 | 2013 |
