| Alzheimer's Disease P Scheltens, K Blennow, M Breteler, B De Strooper, ... Lancet 338 (10043), 505-517, 2016 | 2683 | 2016 |
| A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain B De Strooper, W Annaert, P Cupers, P Saftig, K Craessaerts, JS Mumm, ... Nature 398 (6727), 518-522, 1999 | 2607 | 1999 |
| The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics E Karran, M Mercken, BD Strooper Nature reviews Drug discovery 10 (9), 698-712, 2011 | 2398 | 2011 |
| Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein B De Strooper, P Saftig, K Craessaerts, H Vanderstichele, G Guhde, ... Nature 391 (6665), 387-390, 1998 | 2340 | 1998 |
| The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes I Benilova, E Karran, B De Strooper Nature neuroscience 15 (3), 349-357, 2012 | 2082 | 2012 |
| OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion C Frezza, S Cipolat, OM De Brito, M Micaroni, GV Beznoussenko, ... Cell 126 (1), 177-189, 2006 | 1631 | 2006 |
| Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons M Simons, P Keller, B De Strooper, K Beyreuther, CG Dotti, K Simons Proceedings of the National Academy of Sciences 95 (11), 6460-6464, 1998 | 1488 | 1998 |
| The cellular phase of Alzheimer’s disease B De Strooper, E Karran Cell 164 (4), 603-615, 2016 | 1375 | 2016 |
| Aph-1, Pen-2, and nicastrin with presenilin generate an active γ-secretase complex B De Strooper Neuron 38 (1), 9-12, 2003 | 1304 | 2003 |
| Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression SS Hébert, K Horré, L Nicolaï, AS Papadopoulou, W Mandemakers, ... Proceedings of the National Academy of Sciences 105 (17), 6415-6420, 2008 | 1280 | 2008 |
| Control of peripheral nerve myelination by the ß-secretase BACE1 M Willem, AN Garratt, B Novak, M Citron, S Kaufmann, A Rittger, ... Science 314 (5799), 664-666, 2006 | 889 | 2006 |
| Proteolytic processing and cell biological functions of the amyloid precursor protein B De Strooper, W Annaert Journal of cell science 113 (11), 1857-1870, 2000 | 874 | 2000 |
| The secretases: enzymes with therapeutic potential in Alzheimer disease B De Strooper, R Vassar, T Golde Nature reviews neurology 6 (2), 99-107, 2010 | 870 | 2010 |
| The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for α-secretase activity in fibroblasts D Hartmann, B De Strooper, L Serneels, K Craessaerts, A Herreman, ... Human molecular genetics 11 (21), 2615-2624, 2002 | 826 | 2002 |
| Reactive astrocyte nomenclature, definitions, and future directions C Escartin, E Galea, A Lakatos, JP O’Callaghan, GC Petzold, ... Nature neuroscience 24 (3), 312-325, 2021 | 811 | 2021 |
| Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling S Cipolat, T Rudka, D Hartmann, V Costa, L Serneels, K Craessaerts, ... Cell 126 (1), 163-175, 2006 | 804 | 2006 |
| Alzheimer's disease P Scheltens, B De Strooper, M Kivipelto, H Holstege, G Chételat, ... The Lancet 397 (10284), 1577-1590, 2021 | 774 | 2021 |
| ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and β-catenin translocation T Maretzky, K Reiss, A Ludwig, J Buchholz, F Scholz, E Proksch, ... Proceedings of the National Academy of Sciences 102 (26), 9182-9187, 2005 | 769 | 2005 |
| Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations H Tu, O Nelson, A Bezprozvanny, Z Wang, SF Lee, YH Hao, L Serneels, ... Cell 126 (5), 981-993, 2006 | 745 | 2006 |
| Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis Z Zhang, H Hartmann, V Minh Do, D Abramowski, C Sturchler-Pierrat, ... Nature 395 (6703), 698-702, 1998 | 709 | 1998 |
Paul SaftigProfessor of BiochemistryVerified email at biochem.uni-kiel.de
