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Brian Carroll
Brian Carroll
Scientist Manager, Primus Pharamceuticals
Verifisert e-postadresse på primusrx.com
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Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits
LJ MacPherson, EK Bayburt, MP Capparelli, BJ Carroll, R Goldstein, ...
Journal of medicinal chemistry 40 (16), 2525-2532, 1997
4051997
The Post-Polyketide Synthase Modification Steps in the Biosynthesis of the Antitumor Agent Ansamitocin by Actinosynnema p retiosum
P Spiteller, L Bai, G Shang, BJ Carroll, TW Yu, HG Floss
Journal of the American Chemical Society 125 (47), 14236-14237, 2003
972003
Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of taxol catalyzed by recombinant taxadiene synthase
DC Williams, BJ Carroll, Q Jin, CD Rithner, SR Lenger, HG Floss, ...
Chemistry & biology 7 (12), 969-977, 2000
922000
Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual “glycolate” chain extension unit in ansamitocin biosynthesis
BJ Carroll, SJ Moss, L Bai, Y Kato, S Toelzer, TW Yu, HG Floss
Journal of the American Chemical Society 124 (16), 4176-4177, 2002
912002
On the biosynthetic origin of methoxymalonyl-acyl carrier protein, the substrate for incorporation of “glycolate” units into ansamitocin and soraphen A
SC Wenzel, RM Williamson, C Grünanger, J Xu, K Gerth, RA Martinez, ...
Journal of the American Chemical Society 128 (44), 14325-14336, 2006
862006
Identification of asm19 as an acyltransferase attaching the biologically essential ester side chain of ansamitocins using N-desmethyl-4, 5-desepoxymaytansinol, not maytansinol …
SJ Moss, L Bai, S Toelzer, BJ Carroll, T Mahmud, TW Yu, HG Floss
Journal of the American Chemical Society 124 (23), 6544-6545, 2002
552002
N‐methylation of the amide bond by methyltransferase asm10 in ansamitocin biosynthesis
Y Wu, Q Kang, G Shang, P Spiteller, B Carroll, TW Yu, W Su, L Bai, ...
ChemBioChem 12 (11), 1759-1766, 2011
222011
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