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Miriam Kutsch
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Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions
M Kutsch, L Sistemich, CF Lesser, MB Goldberg, C Herrmann, J Coers
The EMBO journal 39 (13), e104926, 2020
1112020
Nucleotide-dependent farnesyl switch orchestrates polymerization and membrane binding of human guanylate-binding protein 1
S Shydlovskyi, AY Zienert, S Ince, C Dovengerds, A Hohendahl, ...
Proceedings of the National Academy of Sciences 114 (28), E5559-E5568, 2017
562017
Human guanylate binding proteins: nanomachines orchestrating host defense
M Kutsch, J Coers
The FEBS journal 288 (20), 5826-5849, 2021
492021
Dynamin‐related Irgm proteins modulate LPS‐induced caspase‐11 activation and septic shock
R Finethy, J Dockterman, M Kutsch, N Orench‐Rivera, GD Wallace, ...
EMBO reports 21 (11), e50830, 2020
442020
The human guanylate‐binding proteins hGBP‐1 and hGBP‐5 cycle between monomers and dimers only
S Ince, M Kutsch, S Shydlovskyi, C Herrmann
The FEBS Journal 284 (14), 2284-2301, 2017
322017
Identification of protein phosphatase 2A as an interacting protein of leucine-rich repeat kinase 2
PS Athanasopoulos, W Jacob, S Neumann, M Kutsch, D Wolters, EK Tan, ...
Biological Chemistry 397 (6), 541-554, 2016
232016
The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction
SC Walsh, JR Reitano, MS Dickinson, M Kutsch, D Hernandez, ...
Cell host & microbe 30 (12), 1671-1684. e9, 2022
222022
The molecular mechanism of polymer formation of farnesylated human guanylate-binding protein 1
L Sistemich, M Kutsch, B Hämisch, P Zhang, S Shydlovskyi, ...
Journal of molecular biology 432 (7), 2164-2185, 2020
212020
A rapidly evolving polybasic motif modulates bacterial detection by guanylate binding proteins
KM Kohler, M Kutsch, AS Piro, GD Wallace, J Coers, MF Barber
MBio 11 (3), 10.1128/mbio. 00340-20, 2020
192020
LPS-aggregating proteins GBP1 and GBP2 are each sufficient to enhance caspase-4 activation both in cellulo and in vitro
MS Dickinson, M Kutsch, L Sistemich, D Hernandez, AS Piro, D Needham, ...
Proceedings of the National Academy of Sciences 120 (15), e2216028120, 2023
162023
Dissecting ion-specific from electrostatic salt effects on amyloid fibrillation: A case study of insulin
M Kutsch, P Hortmann, C Herrmann, S Weibels, H Weingärtner
Biointerphases 11 (1), 2016
122016
Structural requirements for membrane binding of human guanylate‐binding protein 1
L Sistemich, L Dimitrov Stanchev, M Kutsch, A Roux, ...
The FEBS Journal 288 (13), 4098-4114, 2021
112021
Catalytic activity of human guanylate‐binding protein 1 coupled to the release of structural restraints imposed by the C‐terminal domain
S Ince, P Zhang, M Kutsch, O Krenczyk, S Shydlovskyi, C Herrmann
The FEBS Journal 288 (2), 582-599, 2021
92021
The GBP1 microcapsule interferes with IcsA-dependent septin cage assembly around Shigella flexneri
M Kutsch, C Gonzalez-Prieto, CF Lesser, J Coers
Pathogens and Disease 79 (5), ftab023, 2021
62021
Homo and hetero dimerisation of the human guanylate‐binding proteins hGBP‐1 and hGBP‐5 characterised by affinities and kinetics
M Kutsch, S Ince, C Herrmann
The FEBS Journal 285 (11), 2019-2036, 2018
42018
GBP2 aggregates LPS and activates the caspase-4 inflammasome independent of the bacterial encapsulation factor GBP1
MS Dickinson, M Kutsch, L Sistemich, D Hernandez, AS Piro, D Needham, ...
Biorxiv, 2022.10. 05.511023, 2022
32022
Kleb‘s zusammen & zerleg‘s: Detergensproteine in der zelleigenen Immunität
M Kutsch
BIOspektrum 30 (2), 162-164, 2024
2024
Structural insights into the activation mechanism of antimicrobial GBP1
M Weismehl, X Chu, M Kutsch, P Lauterjung, C Herrmann, M Kudryashev, ...
The EMBO Journal 43 (4), 615-636, 2024
2024
Elucidating the activation mechanism for GBP1 oligomerization
O Daumke, M Weismehl, X Chu, M Kutsch, P Lauterjung, C Herrmann, ...
bioRxiv, 2023.08. 01.551421, 2023
2023
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