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Karl Peggs
Karl Peggs
Professor of Transplant Science and Cancer Immunotherapy, UCL
Verifisert e-postadresse på ucl.ac.uk
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Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
N McGranahan, AJS Furness, R Rosenthal, S Ramskov, R Lyngaa, ...
Science 351 (6280), 1463-1469, 2016
29282016
ASTCT consensus grading for cytokine release syndrome and neurologic toxicity associated with immune effector cells
DW Lee, BD Santomasso, FL Locke, A Ghobadi, CJ Turtle, JN Brudno, ...
Biology of blood and marrow transplantation 25 (4), 625-638, 2019
21002019
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
C Abbosh, NJ Birkbak, GA Wilson, M Jamal-Hanjani, T Constantin, ...
Nature 545 (7655), 446-451, 2017
16712017
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma
TR Simpson, F Li, W Montalvo-Ortiz, MA Sepulveda, K Bergerhoff, F Arce, ...
Journal of Experimental Medicine 210 (9), 1695-1710, 2013
15632013
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies
KS Peggs, SA Quezada, CA Chambers, AJ Korman, JP Allison
Journal of Experimental Medicine 206 (8), 1717-1725, 2009
10752009
Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts
SA Quezada, TR Simpson, KS Peggs, T Merghoub, J Vider, X Fan, ...
Journal of Experimental Medicine 207 (3), 637-650, 2010
9722010
Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells
W Qasim, H Zhan, S Samarasinghe, S Adams, P Amrolia, S Stafford, ...
Science translational medicine 9 (374), eaaj2013, 2017
9432017
CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells
SA Quezada, KS Peggs, MA Curran, JP Allison
The Journal of clinical investigation 116 (7), 1935-1945, 2006
7912006
Checkpoint blockade in cancer immunotherapy
AJ Korman, KS Peggs, JP Allison
Advances in immunology 90, 297-339, 2006
7312006
Multiplex genome-edited T-cell manufacturing platform for “off-the-shelf” adoptive T-cell immunotherapies
L Poirot, B Philip, C Schiffer-Mannioui, D Le Clerre, I Chion-Sotinel, ...
Cancer research 75 (18), 3853-3864, 2015
6182015
In vivo CAMPATH-1H prevents graft-versus-host disease following nonmyeloablative stem cell transplantation
PD Kottaridis, DW Milligan, R Chopra, RK Chakraverty, S Chakrabarti, ...
Blood, The Journal of the American Society of Hematology 96 (7), 2419-2425, 2000
6012000
Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines
KS Peggs, S Verfuerth, A Pizzey, N Khan, M Guiver, PA Moss, ...
The Lancet 362 (9393), 1375-1377, 2003
5852003
Principles and use of anti-CTLA4 antibody in human cancer immunotherapy
KS Peggs, SA Quezada, AJ Korman, JP Allison
Current opinion in immunology 18 (2), 206-213, 2006
5732006
Fc effector function contributes to the activity of human anti-CTLA-4 antibodies
FA Vargas, AJS Furness, K Litchfield, K Joshi, R Rosenthal, E Ghorani, ...
Cancer cell 33 (4), 649-663. e4, 2018
5312018
Epitope landscape in breast and colorectal cancer
NH Segal, DW Parsons, KS Peggs, V Velculescu, KW Kinzler, ...
Cancer research 68 (3), 889-892, 2008
4832008
High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution
S Chakrabarti, S Mackinnon, R Chopra, PD Kottaridis, K Peggs, ...
Blood, The Journal of the American Society of Hematology 99 (12), 4357-4363, 2002
4262002
A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy
B Philip, E Kokalaki, L Mekkaoui, S Thomas, K Straathof, B Flutter, ...
Blood, The Journal of the American Society of Hematology 124 (8), 1277-1287, 2014
4222014
Fc-optimized anti-CD25 depletes tumor-infiltrating regulatory T cells and synergizes with PD-1 blockade to eradicate established tumors
FA Vargas, AJS Furness, I Solomon, K Joshi, L Mekkaoui, MH Lesko, ...
Immunity 46 (4), 577-586, 2017
4092017
Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimen
R Chakraverty, K Peggs, R Chopra, DW Milligan, PD Kottaridis, ...
Blood, The Journal of the American Society of Hematology 99 (3), 1071-1078, 2002
3992002
Clinical evidence of a graft-versus-Hodgkin's-lymphoma effect after reduced-intensity allogeneic transplantation
KS Peggs, A Hunter, R Chopra, A Parker, P Mahendra, D Milligan, ...
The Lancet 365 (9475), 1934-1941, 2005
3462005
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Artikler 1–20