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Adem Y Dawed
Adem Y Dawed
Precision Medicine Specialist, Novo Nordisk Research Centre Oxford
Verifisert e-postadresse på novonordisk.com
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Pharmacogenomics in diabetes mellitus: insights into drug action and drug discovery
K Zhou, HK Pedersen, AY Dawed, ER Pearson
Nature Reviews Endocrinology 12 (6), 337-346, 2016
752016
CYP2C8 and SLCO1B1 variants and therapeutic response to thiazolidinediones in patients with type 2 diabetes
AY Dawed, L Donnelly, R Tavendale, F Carr, G Leese, CNA Palmer, ...
Diabetes care 39 (11), 1902-1908, 2016
682016
Sustained influence of metformin therapy on circulating glucagon‐like peptide‐1 levels in individuals with and without type 2 diabetes
D Preiss, A Dawed, P Welsh, A Heggie, AG Jones, J Dekker, R Koivula, ...
Diabetes, Obesity and Metabolism 19 (3), 356-363, 2017
672017
Variation in the plasma membrane monoamine transporter (PMAT)(encoded by SLC29A4) and organic cation transporter 1 (OCT1)(encoded by SLC22A1) and gastrointestinal intolerance …
AY Dawed, K Zhou, N van Leeuwen, A Mahajan, N Robertson, R Koivula, ...
Diabetes Care 42 (6), 1027-1033, 2019
622019
Heterogeneity in phenotype, disease progression and drug response in type 2 diabetes
ATN Nair, A Wesolowska-Andersen, C Brorsson, AL Rajendrakumar, ...
Nature medicine 28 (5), 982-988, 2022
602022
Efficacy of modern diabetes treatments DPP-4i, SGLT-2i, and GLP-1RA in white and Asian patients with diabetes: a systematic review and meta-analysis of randomized controlled trials
S Gan, AY Dawed, LA Donnelly, ATN Nair, CNA Palmer, V Mohan, ...
Diabetes Care 43 (8), 1948-1957, 2020
592020
Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts
N Atabaki-Pasdar, M Ohlsson, A Viñuela, F Frau, H Pomares-Millan, ...
PLoS medicine 17 (6), e1003149, 2020
572020
Pharmacogenetics in type 2 diabetes: influence on response to oral hypoglycemic agents
AY Dawed, K Zhou, ER Pearson
Pharmacogenomics and personalized medicine, 17-29, 2016
522016
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine
DK Tobias, J Merino, A Ahmad, C Aiken, JL Benham, D Bodhini, AL Clark, ...
Nature medicine 29 (10), 2438-2457, 2023
412023
Young-onset diabetes in Asian Indians is associated with lower measured and genetically determined beta cell function
MK Siddiqui, RM Anjana, AY Dawed, C Martoeau, S Srinivasan, ...
Diabetologia 65 (6), 973-983, 2022
412022
Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials
AY Dawed, A Mari, A Brown, TJ McDonald, L Li, S Wang, MG Hong, ...
The Lancet Diabetes & Endocrinology 11 (1), 33-41, 2023
372023
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI …
RW Koivula, IM Forgie, A Kurbasic, A Viñuela, A Heggie, GN Giordano, ...
Diabetologia 62, 1601-1615, 2019
372019
Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models
RL Allesøe, AT Lundgaard, R Hernández Medina, A Aguayo-Orozco, ...
Nature Biotechnology 41 (3), 399-408, 2023
282023
Genome-wide meta-analysis identifies genetic variants associated with glycemic response to sulfonylureas
AY Dawed, SW Yee, K Zhou, N van Leeuwen, Y Zhang, MK Siddiqui, ...
Diabetes Care 44 (12), 2673-2682, 2021
272021
A polygenic score for type 2 diabetes risk is associated with both the acute and sustained response to sulfonylureas
JH Li, L Szczerbinski, AY Dawed, V Kaur, JN Todd, ER Pearson, ...
Diabetes 70 (1), 293-300, 2021
272021
Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration
HR Wilman, CA Parisinos, N Atabaki-Pasdar, M Kelly, EL Thomas, ...
Journal of Hepatology 71 (3), 594-602, 2019
272019
Common Statin Intolerance Variants in ABCB1 and LILRB5 Show Synergistic Effects on Statin Response: An Observational Study Using Electronic Health Records
AL Melhem, MK Chourasia, M Bigossi, C Maroteau, A Taylor, R Pola, ...
Frontiers in Genetics 12, 713181, 2021
142021
The impact of phenotype, ethnicity and genotype on progression of type 2 diabetes mellitus
A Thakarakkattil Narayanan Nair, LA Donnelly, AY Dawed, S Gan, ...
Endocrinology, Diabetes & Metabolism 3 (2), e00108, 2020
132020
The genetics of adverse drug outcomes in type 2 diabetes: A systematic review
AM Baye, TG Fanta, MK Siddiqui, AY Dawed
Frontiers in Genetics 12, 675053, 2021
122021
Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study
V Gudmundsdottir, HK Pedersen, KV Allebrandt, C Brorsson, ...
PloS one 13 (1), e0189886, 2018
112018
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