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Matthew Guenther
Matthew Guenther
Syros Pharmaceuticals
Verifisert e-postadresse på wi.mit.edu
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Core transcriptional regulatory circuitry in human embryonic stem cells
LA Boyer, TI Lee, MF Cole, SE Johnstone, SS Levine, JP Zucker, ...
cell 122 (6), 947-956, 2005
52622005
Control of developmental regulators by Polycomb in human embryonic stem cells
TI Lee, RG Jenner, LA Boyer, MG Guenther, SS Levine, RM Kumar, ...
Cell 125 (2), 301-313, 2006
25952006
A chromatin landmark and transcription initiation at most promoters in human cells
MG Guenther, SS Levine, LA Boyer, R Jaenisch, RA Young
Cell 130 (1), 77-88, 2007
21812007
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
CJ Phiel, F Zhang, EY Huang, MG Guenther, MA Lazar, PS Klein
Journal of Biological Chemistry 276 (39), 36734-36741, 2001
19972001
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells
A Marson, SS Levine, MF Cole, GM Frampton, T Brambrink, S Johnstone, ...
cell 134 (3), 521-533, 2008
16942008
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR
W Fischle, F Dequiedt, MJ Hendzel, MG Guenther, MA Lazar, W Voelter, ...
Molecular cell 9 (1), 45-57, 2002
8892002
The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3
MG Guenther, ORR Barak, MA Lazar
Molecular and cellular biology 21 (18), 6091-6101, 2001
7282001
Master transcription factors determine cell-type-specific responses to TGF-β signaling
AC Mullen, DA Orlando, JJ Newman, J Lovén, RM Kumar, S Bilodeau, ...
Cell 147 (3), 565-576, 2011
6182011
A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness
MG Guenther, WS Lane, W Fischle, E Verdin, MA Lazar, R Shiekhattar
Genes & development 14 (9), 1048-1057, 2000
5652000
Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells
MG Guenther, GM Frampton, F Soldner, D Hockemeyer, M Mitalipova, ...
Cell stem cell 7 (2), 249-257, 2010
5232010
Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells
AA Sigova, AC Mullen, B Molinie, S Gupta, DA Orlando, MG Guenther, ...
Proceedings of the National Academy of Sciences 110 (8), 2876-2881, 2013
4672013
Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations
CJ Lengner, AA Gimelbrant, JA Erwin, AW Cheng, MG Guenther, ...
Cell 141 (5), 872-883, 2010
4292010
Global and Hox-specific roles for the MLL1 methyltransferase
MG Guenther, RG Jenner, B Chevalier, T Nakamura, CM Croce, ...
Proceedings of the National Academy of Sciences 102 (24), 8603-8608, 2005
4172005
Quantitative ChIP-Seq normalization reveals global modulation of the epigenome
DA Orlando, MW Chen, VE Brown, S Solanki, YJ Choi, ER Olson, CC Fritz, ...
Cell reports 9 (3), 1163-1170, 2014
4002014
Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway
EY Huang, J Zhang, EA Miska, MG Guenther, T Kouzarides, MA Lazar
Genes & development 14 (1), 45-54, 2000
3952000
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia
MG Guenther, LN Lawton, T Rozovskaia, GM Frampton, SS Levine, ...
Genes & development 22 (24), 3403-3408, 2008
2792008
Proteasomal regulation of nuclear receptor corepressor-mediated repression
J Zhang, MG Guenther, RW Carthew, MA Lazar
Genes & development 12 (12), 1775-1780, 1998
2741998
Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response
GD Kao, WG McKenna, MG Guenther, RJ Muschel, MA Lazar, TJ Yen
The Journal of cell biology 160 (7), 1017-1027, 2003
2402003
A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation
J Yu, Y Li, T Ishizuka, MG Guenther, MA Lazar
The EMBO journal 22 (13), 3403-3410, 2003
2242003
Genome-wide localization of small molecules
L Anders, MG Guenther, J Qi, ZP Fan, JJ Marineau, PB Rahl, J Loven, ...
Nature biotechnology 32 (1), 92-96, 2014
1752014
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Artikler 1–20