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Nicolas Casadei
Nicolas Casadei
Head genomics core facility, Group leader Parkinson's disease, Institute of Human Genetics and
Verifisert e-postadresse på med.uni-tuebingen.de - Startside
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Swarm learning for decentralized and confidential clinical machine learning
S Warnat-Herresthal, H Schultze, KL Shastry, S Manamohan, ...
Nature 594 (7862), 265-270, 2021
5612021
Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats
N Van Den Berge, N Ferreira, H Gram, TW Mikkelsen, AKO Alstrup, ...
Acta neuropathologica 138 (4), 535-550, 2019
2642019
rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration
M Oliveras-Salvá, A Van der Perren, N Casadei, S Stroobants, S Nuber, ...
Molecular neurodegeneration 8, 1-14, 2013
1982013
Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19
B Krämer, R Knoll, L Bonaguro, M ToVinh, J Raabe, ...
Immunity 54 (11), 2650-2669. e14, 2021
1712021
Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease
P Krashia, A Cordella, A Nobili, L La Barbera, M Federici, A Leuti, ...
Nature communications 10 (1), 3945, 2019
1592019
A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats
S Nuber, F Harmuth, Z Kohl, A Adame, M Trejo, K Schönig, ...
Brain 136 (2), 412-432, 2013
1542013
Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P] αSyn transgenic mice
M Diepenbroek, N Casadei, H Esmer, TC Saido, J Takano, PJ Kahle, ...
Human molecular genetics 23 (15), 3975-3989, 2014
1222014
Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors
A Van der Perren, J Toelen, C Casteels, F Macchi, AS Van Rompuy, ...
Neurobiology of aging 36 (3), 1543-1558, 2015
1132015
α-Synuclein in Parkinson’s disease: causal or bystander?
P Riederer, D Berg, N Casadei, F Cheng, J Classen, C Dresel, W Jost, ...
Journal of neural transmission 126, 815-840, 2019
1032019
Immunophenotyping in pemphigus reveals a TH17/TFH17 cell–dominated immune response promoting desmoglein1/3-specific autoantibody production
J Holstein, F Solimani, C Baum, K Meier, R Pollmann, D Didona, T Tekath, ...
Journal of Allergy and Clinical Immunology 147 (6), 2358-2369, 2021
522021
Comparative targeting analysis of KLF1, BCL11A, and HBG1/2 in CD34+ HSPCs by CRISPR/Cas9 for the induction of fetal hemoglobin
A Lamsfus-Calle, A Daniel-Moreno, JS Antony, T Epting, L Heumos, ...
Scientific reports 10 (1), 10133, 2020
522020
Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy
G Minakaki, F Canneva, F Chevessier, F Bode, S Menges, IK Timotius, ...
Behavioural brain research 363, 199-215, 2019
372019
Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice
S Nuber, T Franck, H Wolburg, U Schumann, N Casadei, K Fischer, ...
Neurogenetics 11, 107-120, 2010
332010
Ubiquitin-specific protease USP36 knockdown impairs Parkin-dependent mitophagy via downregulation of Beclin-1-associated autophagy-related ATG14L
S Geisler, L Jaeger, S Golombek, E Nakanishi, F Hans, N Casadei, ...
Experimental Cell Research 384 (2), 111641, 2019
312019
Environmental enrichment prevents transcriptional disturbances induced by alpha-synuclein overexpression
Z Wassouf, T Hentrich, S Samer, C Rotermund, PJ Kahle, I Ehrlich, ...
Frontiers in cellular neuroscience 12, 112, 2018
312018
Low mutational load in pediatric medulloblastoma still translates into neoantigens as targets for specific T-cell immunotherapy
F Blaeschke, MC Paul, MU Schuhmann, A Rabsteyn, C Schroeder, ...
Cytotherapy 21 (9), 973-986, 2019
302019
Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice
N Casadei, AM Pöhler, C Tomas-Zapico, J Torres-Peraza, I Schwedhelm, ...
Human molecular genetics 23 (3), 767-781, 2014
282014
Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative
G Butler-Laporte, G Povysil, JA Kosmicki, ET Cirulli, T Drivas, S Furini, ...
PLoS genetics 18 (11), e1010367, 2022
272022
Genomic surveillance of SARS-CoV-2 in the Republic of Congo
F Ntoumi, CCM Mapanguy, A Tomazatos, SR Pallerla, N Casadei, ...
International Journal of Infectious Diseases 105, 735-738, 2021
262021
A novel SCA3 knock-in mouse model mimics the human SCA3 disease phenotype including neuropathological, behavioral, and transcriptional abnormalities especially in oligodendrocytes
E Haas, RD Incebacak, T Hentrich, C Huridou, T Schmidt, N Casadei, ...
Molecular neurobiology, 1-28, 2022
252022
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Artikler 1–20