| I-motif DNA structures are formed in the nuclei of human cells M Zeraati, DB Langley, P Schofield, AL Moye, R Rouet, WE Hughes, ... Nature chemistry 10 (6), 631-637, 2018 | 422 | 2018 |
| Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity Z Sabouri, P Schofield, K Horikawa, E Spierings, D Kipling, KL Randall, ... Proceedings of the National Academy of Sciences 111 (25), E2567-E2575, 2014 | 235 | 2014 |
| General strategy for the generation of human antibody variable domains with increased aggregation resistance K Dudgeon, R Rouet, I Kokmeijer, P Schofield, J Stolp, D Langley, ... Proceedings of the National Academy of Sciences 109 (27), 10879-10884, 2012 | 198 | 2012 |
| Preparing monodisperse macromolecular samples for successful biological small-angle X-ray and neutron-scattering experiments CM Jeffries, MA Graewert, CE Blanchet, DB Langley, AE Whitten, ... Nature protocols 11 (11), 2122-2153, 2016 | 144 | 2016 |
| Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination DL Burnett, DB Langley, P Schofield, JR Hermes, TD Chan, J Jackson, ... Science 360 (6385), 223-226, 2018 | 121 | 2018 |
| The crystal structure of Pichia pastoris lysyl oxidase AP Duff, AE Cohen, PJ Ellis, JA Kuchar, DB Langley, EM Shepard, ... Biochemistry 42 (51), 15148-15157, 2003 | 112 | 2003 |
| Crystal structures of recombinant human purple acid phosphatase with and without an inhibitory conformation of the repression loop N Sträter, B Jasper, M Scholte, B Krebs, AP Duff, DB Langley, R Han, ... Journal of molecular biology 351 (1), 233-246, 2005 | 92 | 2005 |
| The structure of the KinA-Sda complex suggests an allosteric mechanism of histidine kinase inhibition AE Whitten, DA Jacques, B Hammouda, T Hanley, GF King, JM Guss, ... Journal of molecular biology 368 (2), 407-420, 2007 | 87 | 2007 |
| Lymphoma driver mutations in the pathogenic evolution of an iconic human autoantibody M Singh, KJL Jackson, JJ Wang, P Schofield, MA Field, D Koppstein, ... Cell 180 (5), 878-894. e19, 2020 | 73 | 2020 |
| Structural basis for hemoglobin capture by Staphylococcus aureus cell-surface protein, IsdH KK Kumar, DA Jacques, G Pishchany, T Caradoc-Davies, T Spirig, ... Journal of Biological Chemistry 286 (44), 38439-38447, 2011 | 72 | 2011 |
| Next-generation sequencing of antibody display repertoires R Rouet, KJL Jackson, DB Langley, D Christ Frontiers in immunology 9, 118, 2018 | 70 | 2018 |
| Using xenon as a probe for dioxygen-binding sites in copper amine oxidases AP Duff, DM Trambaiolo, AE Cohen, PJ Ellis, GA Juda, EM Shepard, ... Journal of molecular biology 344 (3), 599-607, 2004 | 69 | 2004 |
| Ligand-induced conformational changes and conformational dynamics in the solution structure of the lactose repressor protein M Taraban, H Zhan, AE Whitten, DB Langley, KS Matthews, L Swint-Kruse, ... Journal of molecular biology 376 (2), 466-481, 2008 | 67 | 2008 |
| Expression of high-affinity human antibody fragments in bacteria R Rouet, D Lowe, K Dudgeon, B Roome, P Schofield, D Langley, ... nature protocols 7 (2), 364-373, 2012 | 65 | 2012 |
| Porphyrin-Mediated Cell Surface Heme Capture from Hemoglobin by Porphyromonas gingivalis M Paramaesvaran, KA Nguyen, E Caldon, JA McDonald, S Najdi, ... Journal of bacteriology 185 (8), 2528-2537, 2003 | 63 | 2003 |
| SARS-CoV-2 Omicron: evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern A Aggarwal, AO Stella, G Walker, A Akerman, V Milogiannakis, F Brilot, ... medrxiv, 2021.12. 14.21267772, 2021 | 61 | 2021 |
| Structure of N-acetyl-β-D-glucosaminidase (GcnA) from the endocarditis pathogen Streptococcus gordonii and its complex with the mechanism-based inhibitor NAG-thiazoline DB Langley, DWS Harty, NA Jacques, N Hunter, JM Guss, CA Collyer Journal of molecular biology 377 (1), 104-116, 2008 | 55 | 2008 |
| Fully human VH single domains that rival the stability and cleft recognition of camelid antibodies R Rouet, K Dudgeon, M Christie, D Langley, D Christ Journal of Biological Chemistry 290 (19), 11905-11917, 2015 | 50 | 2015 |
| Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity NW Zammit, OM Siggs, PE Gray, K Horikawa, DB Langley, SN Walters, ... Nature immunology 20 (10), 1299-1310, 2019 | 47 | 2019 |
| Mechanism of Inactivation of Ornithine Transcarbamoylase by N δ-(N′-Sulfodiaminophosphinyl)-l-ornithine, a True Transition State Analogue?: CRYSTAL STRUCTURE AND IMPLICATIONS … DB Langley, MD Templeton, BA Fields, RE Mitchell, CA Collyer Journal of Biological Chemistry 275 (26), 20012-20019, 2000 | 46 | 2000 |
