David Brent Langley
David Brent Langley
Verifisert e-postadresse på garvan.org.au
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Sitert av
I-motif DNA structures are formed in the nuclei of human cells
M Zeraati, DB Langley, P Schofield, AL Moye, R Rouet, WE Hughes, ...
Nature chemistry 10 (6), 631-637, 2018
Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity
Z Sabouri, P Schofield, K Horikawa, E Spierings, D Kipling, KL Randall, ...
Proceedings of the National Academy of Sciences 111 (25), E2567-E2575, 2014
General strategy for the generation of human antibody variable domains with increased aggregation resistance
K Dudgeon, R Rouet, I Kokmeijer, P Schofield, J Stolp, D Langley, ...
Proceedings of the National Academy of Sciences 109 (27), 10879-10884, 2012
Preparing monodisperse macromolecular samples for successful biological small-angle X-ray and neutron-scattering experiments
CM Jeffries, MA Graewert, CE Blanchet, DB Langley, AE Whitten, ...
Nature protocols 11 (11), 2122-2153, 2016
Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination
DL Burnett, DB Langley, P Schofield, JR Hermes, TD Chan, J Jackson, ...
Science 360 (6385), 223-226, 2018
The crystal structure of Pichia pastoris lysyl oxidase
AP Duff, AE Cohen, PJ Ellis, JA Kuchar, DB Langley, EM Shepard, ...
Biochemistry 42 (51), 15148-15157, 2003
Crystal structures of recombinant human purple acid phosphatase with and without an inhibitory conformation of the repression loop
N Sträter, B Jasper, M Scholte, B Krebs, AP Duff, DB Langley, R Han, ...
Journal of molecular biology 351 (1), 233-246, 2005
The structure of the KinA-Sda complex suggests an allosteric mechanism of histidine kinase inhibition
AE Whitten, DA Jacques, B Hammouda, T Hanley, GF King, JM Guss, ...
Journal of molecular biology 368 (2), 407-420, 2007
Lymphoma driver mutations in the pathogenic evolution of an iconic human autoantibody
M Singh, KJL Jackson, JJ Wang, P Schofield, MA Field, D Koppstein, ...
Cell 180 (5), 878-894. e19, 2020
Structural basis for hemoglobin capture by Staphylococcus aureus cell-surface protein, IsdH
KK Kumar, DA Jacques, G Pishchany, T Caradoc-Davies, T Spirig, ...
Journal of Biological Chemistry 286 (44), 38439-38447, 2011
Next-generation sequencing of antibody display repertoires
R Rouet, KJL Jackson, DB Langley, D Christ
Frontiers in immunology 9, 118, 2018
Using xenon as a probe for dioxygen-binding sites in copper amine oxidases
AP Duff, DM Trambaiolo, AE Cohen, PJ Ellis, GA Juda, EM Shepard, ...
Journal of molecular biology 344 (3), 599-607, 2004
Ligand-induced conformational changes and conformational dynamics in the solution structure of the lactose repressor protein
M Taraban, H Zhan, AE Whitten, DB Langley, KS Matthews, L Swint-Kruse, ...
Journal of molecular biology 376 (2), 466-481, 2008
Expression of high-affinity human antibody fragments in bacteria
R Rouet, D Lowe, K Dudgeon, B Roome, P Schofield, D Langley, ...
nature protocols 7 (2), 364-373, 2012
Porphyrin-Mediated Cell Surface Heme Capture from Hemoglobin by Porphyromonas gingivalis
M Paramaesvaran, KA Nguyen, E Caldon, JA McDonald, S Najdi, ...
Journal of bacteriology 185 (8), 2528-2537, 2003
SARS-CoV-2 Omicron: evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern
A Aggarwal, AO Stella, G Walker, A Akerman, V Milogiannakis, F Brilot, ...
medrxiv, 2021.12. 14.21267772, 2021
Structure of N-acetyl-β-D-glucosaminidase (GcnA) from the endocarditis pathogen Streptococcus gordonii and its complex with the mechanism-based inhibitor NAG-thiazoline
DB Langley, DWS Harty, NA Jacques, N Hunter, JM Guss, CA Collyer
Journal of molecular biology 377 (1), 104-116, 2008
Fully human VH single domains that rival the stability and cleft recognition of camelid antibodies
R Rouet, K Dudgeon, M Christie, D Langley, D Christ
Journal of Biological Chemistry 290 (19), 11905-11917, 2015
Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity
NW Zammit, OM Siggs, PE Gray, K Horikawa, DB Langley, SN Walters, ...
Nature immunology 20 (10), 1299-1310, 2019
Mechanism of Inactivation of Ornithine Transcarbamoylase by N δ-(N′-Sulfodiaminophosphinyl)-l-ornithine, a True Transition State Analogue?: CRYSTAL STRUCTURE AND IMPLICATIONS …
DB Langley, MD Templeton, BA Fields, RE Mitchell, CA Collyer
Journal of Biological Chemistry 275 (26), 20012-20019, 2000
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