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Luke Gaughan
Luke Gaughan
Verifisert e-postadresse på ncl.ac.uk
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Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer
K Halkidou, L Gaughan, S Cook, HY Leung, DE Neal, CN Robson
The Prostate 59 (2), 177-189, 2004
7002004
Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor
L Gaughan, IR Logan, S Cook, DE Neal, CN Robson
Journal of Biological Chemistry 277 (29), 25904-25913, 2002
3802002
Tip60 is a nuclear hormone receptor coactivator
ME Brady, DM Ozanne, L Gaughan, I Waite, S Cook, DE Neal, ...
Journal of Biological Chemistry 274 (25), 17599-17604, 1999
3101999
The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer
EL Clark, A Coulson, C Dalgliesh, P Rajan, SM Nicol, S Fleming, R Heer, ...
Cancer research 68 (19), 7938-7946, 2008
2252008
Androgen receptor nuclear translocation is facilitated by the f-actin cross-linking protein filamin
DM Ozanne, ME Brady, S Cook, L Gaughan, DE Neal, CN Robson
Molecular endocrinology 14 (10), 1618-1626, 2000
2242000
Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation
L Gaughan, IR Logan, DE Neal, CN Robson
Nucleic acids research 33 (1), 13-26, 2005
2082005
Regulation of the androgen receptor by SET9-mediated methylation
L Gaughan, J Stockley, N Wang, SRC McCracken, A Treumann, ...
Nucleic acids research 39 (4), 1266-1279, 2011
1432011
The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover
K Coffey, L Rogerson, C Ryan-Munden, D Alkharaif, J Stockley, R Heer, ...
Nucleic acids research 41 (8), 4433-4446, 2013
1332013
2, 4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer
A Blomme, CA Ford, E Mui, R Patel, C Ntala, LE Jamieson, M Planque, ...
Nature Communications 11 (1), 2508, 2020
1212020
Tip60 is a co-activator specific for class I nuclear hormone receptors
L Gaughan, ME Brady, S Cook, DE Neal, CN Robson
Journal of Biological Chemistry 276 (50), 46841-46848, 2001
1172001
Human PIRH2 enhances androgen receptor signaling through inhibition of histone deacetylase 1 and is overexpressed in prostate cancer
IR Logan, L Gaughan, SRC McCracken, V Sapountzi, HY Leung, ...
Molecular and cellular biology 26 (17), 6502-6510, 2006
1102006
Control of human PIRH2 protein stability: involvement of TIP60 and the proteasome
IR Logan, V Sapountzi, L Gaughan, DE Neal, CN Robson
Journal of Biological Chemistry 279 (12), 11696-11704, 2004
922004
Deubiquitinating enzyme Usp12 is a novel co-activator of the androgen receptor
UL Burska, VJ Harle, K Coffey, S Darby, H Ramsey, D O'Neill, IR Logan, ...
Journal of Biological Chemistry 288 (45), 32641-32650, 2013
902013
The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer
MA Wade, D Jones, L Wilson, J Stockley, K Coffey, CN Robson, ...
Nucleic acids research 43 (1), 196-207, 2015
892015
A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions
S Awasthi, A Sharma, K Wong, J Zhang, EF Matlock, L Rogers, P Motloch, ...
Molecular and cellular biology 25 (14), 6178-6198, 2005
882005
The RNA‐binding and adaptor protein Sam68 modulates signal‐dependent splicing and transcriptional activity of the androgen receptor
P Rajan, L Gaughan, C Dalgliesh, A El‐Sherif, CN Robson, HY Leung, ...
The Journal of Pathology: A Journal of the Pathological Society of Great …, 2008
872008
Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors
IG Mills, L Gaughan, C Robson, T Ross, S McCracken, J Kelly, DE Neal
The Journal of cell biology 170 (2), 191-200, 2005
872005
Tartrazine and sunset yellow are xenoestrogens in a new screening assay to identify modulators of human oestrogen receptor transcriptional activity
A Axon, FEB May, LE Gaughan, FM Williams, PG Blain, MC Wright
Toxicology 298 (1-3), 40-51, 2012
852012
AZD3514: A Small Molecule That Modulates Androgen Receptor Signaling and Function In Vitro and In Vivo
SA Loddick, SJ Ross, AG Thomason, DM Robinson, GE Walker, ...
Molecular cancer therapeutics 12 (9), 1715-1727, 2013
842013
KDM4B is a master regulator of the estrogen receptor signalling cascade
L Gaughan, J Stockley, K Coffey, D O’Neill, DL Jones, M Wade, J Wright, ...
Nucleic acids research 41 (14), 6892-6904, 2013
812013
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Artikler 1–20