Gavin Williams
Sitert av
Sitert av
Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution
GJ Williams, C Zhang, JS Thorson
Nature chemical biology 3 (10), 657-662, 2007
Probing the aglycon promiscuity of an engineered glycosyltransferase
RW Gantt, RD Goff, GJ Williams, JS Thorson
Angewandte Chemie 120 (46), 9021-9024, 2008
Modifying the stereochemistry of an enzyme-catalyzed reaction by directed evolution
GJ Williams, S Domann, A Nelson, A Berry
Proceedings of the National Academy of Sciences 100 (6), 3143-3148, 2003
Optimizing glycosyltransferase specificity via “hot spot” saturation mutagenesis presents a catalyst for novobiocin glycorandomization
GJ Williams, RD Goff, C Zhang, JS Thorson
Chemistry & biology 15 (4), 393-401, 2008
Directed evolution of enzymes for biocatalysis and the life sciences
GJ Williams, AS Nelson, A Berry
Cellular and Molecular Life Sciences CMLS 61 (24), 3034-3046, 2004
The impact of enzyme engineering upon natural product glycodiversification
GJ Williams, RW Gantt, JS Thorson
Current opinion in chemical biology 12 (5), 556-564, 2008
Engineering polyketide synthases and nonribosomal peptide synthetases
GJ Williams
Current opinion in structural biology 23 (4), 603-612, 2013
Creation of a pair of stereochemically complementary biocatalysts
GJ Williams, T Woodhall, LM Farnsworth, A Nelson, A Berry
Journal of the American Chemical Society 128 (50), 16238-16247, 2006
Poly Specific trans-Acyltransferase Machinery Revealed via Engineered Acyl-CoA Synthetases
I Koryakina, J McArthur, S Randall, MM Draelos, EM Musiol, ...
ACS chemical biology 8 (1), 200-208, 2013
Recombinant E. coli Prototype Strains for in Vivo Glycorandomization
GJ Williams, J Yang, C Zhang, JS Thorson
ACS chemical biology 6 (1), 95-100, 2011
Promiscuity of a modular polyketide synthase towards natural and non-natural extender units
I Koryakina, JB McArthur, MM Draelos, GJ Williams
Organic & biomolecular chemistry 11 (27), 4449-4458, 2013
Natural product glycosyltransferases: properties and applications
GJ Williams, JS Thorson
Advances in Enzymology & Related Areas of Molecular Biology 76, 55, 2009
Mutant malonyl‐CoA synthetases with altered specificity for polyketide synthase extender unit generation
I Koryakina, GJ Williams
ChemBioChem 12 (15), 2289-2293, 2011
Creation of a tailored aldolase for the parallel synthesis of sialic acid mimetics
T Woodhall, G Williams, A Berry, A Nelson
Angewandte Chemie 117 (14), 2147-2150, 2005
Inversion of extender unit selectivity in the erythromycin polyketide synthase by acyltransferase domain engineering
I Koryakina, C Kasey, JB McArthur, AN Lowell, JA Chemler, S Li, ...
ACS chemical biology 12 (1), 114-123, 2017
A high-throughput fluorescence-based glycosyltransferase screen and its application in directed evolution
GJ Williams, JS Thorson
Nature protocols 3 (3), 357-362, 2008
Development of transcription factor-based designer macrolide biosensors for metabolic engineering and synthetic biology
CM Kasey, M Zerrad, Y Li, TA Cropp, GJ Williams
ACS synthetic biology 7 (1), 227-239, 2018
Reprogramming acyl carrier protein interactions of an Acyl-CoA promiscuous trans-acyltransferase
Z Ye, EM Musiol, T Weber, GJ Williams
Chemistry & biology 21 (5), 636-646, 2014
Structure-guided saturation mutagenesis of N-acetylneuraminic acid lyase for the synthesis of sialic acid mimetics
GJ Williams, T Woodhall, A Nelson, A Berry
Protein Engineering Design and Selection 18 (5), 239-246, 2005
Polyketide bioderivatization using the promiscuous acyltransferase KirCII
EM Musiol-Kroll, F Zubeil, T Schafhauser, T Härtner, A Kulik, J McArthur, ...
ACS synthetic biology 6 (3), 421-427, 2017
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