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Mark Dow
Mark Dow
Associate Principal Scientist, AstraZeneca
Verifisert e-postadresse på astrazeneca.com
Tittel
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Sitert av
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A unified lead-oriented synthesis of over fifty molecular scaffolds
RG Doveston, P Tosatti, M Dow, DJ Foley, HY Li, AJ Campbell, D House, ...
Organic & biomolecular chemistry 13 (3), 859-865, 2015
802015
Towards the systematic exploration of chemical space
M Dow, M Fisher, T James, F Marchetti, A Nelson
Organic & biomolecular chemistry 10 (1), 17-28, 2012
762012
Activity‐Directed Synthesis with Intermolecular Reactions: Development of a Fragment into a Range of Androgen Receptor Agonists
G Karageorgis, M Dow, A Aimon, S Warriner, A Nelson
Angewandte Chemie 127 (46), 13742-13748, 2015
392015
Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries
P Craven, A Aimon, M Dow, N Fleury-Bregeot, R Guilleux, R Morgentin, ...
Bioorganic & Medicinal Chemistry 23 (11), 2629-2635, 2015
382015
Modular Synthesis of Diverse Natural Product‐Like Macrocycles: Discovery of Hits with Antimycobacterial Activity
M Dow, F Marchetti, KA Abrahams, L Vaz, GS Besra, S Warriner, A Nelson
Chemistry–A European Journal 23 (30), 7207-7211, 2017
242017
Single point activation of pyridines enables reductive hydroxymethylation
B Marinic, HB Hepburn, A Grozavu, M Dow, TJ Donohoe
Chemical Science 12 (2), 742-746, 2021
232021
Realisation of small molecule libraries based on frameworks distantly related to natural products
A Aimon, G Karageorgis, J Masters, M Dow, PGE Craven, M Ohsten, ...
Organic & biomolecular chemistry 16 (17), 3160-3167, 2018
212018
Translation of innovative chemistry into screening libraries: an exemplar partnership from the European Lead Factory
R Morgentin, M Dow, A Aimon, G Karageorgis, T Kalliokoski, D Roche, ...
Drug discovery today 23 (9), 1578-1583, 2018
192018
Evolution of the Dearomative Functionalization of Activated Quinolines and Isoquinolines: Expansion of the Electrophile Scope
M Kischkewitz, B Marinic, N Kratena, Y Lai, HB Hepburn, M Dow, ...
Angewandte Chemie International Edition 61 (27), e202204682, 2022
162022
Synthesis of skeletally diverse alkaloid-like molecules: exploitation of metathesis substrates assembled from triplets of building blocks
SK Maurya, M Dow, S Warriner, A Nelson
Beilstein Journal of Organic Chemistry 9 (1), 775-785, 2013
142013
Morphological subprofile analysis for bioactivity annotation of small molecules
A Pahl, B Schölermann, P Lampe, M Rusch, M Dow, C Hedberg, ...
Cell Chemical Biology 30 (7), 839-853. e7, 2023
112023
Identification of dihydroorotate dehydrogenase inhibitors using the cell painting assay
B Schölermann, J Bonowski, M Grigalunas, A Burhop, Y Xie, JGF Hoock, ...
ChemBioChem 23 (22), e202200475, 2022
112022
Synthetic Route Design of AZD4635, an A2AR Antagonist
MM Littleson, AD Campbell, A Clarke, M Dow, G Ensor, MC Evans, ...
Organic Process Research & Development 23 (7), 1407-1419, 2019
112019
Efficient Approaches for the Synthesis of Diverse α-Diazo Amides
S Chow, AI Green, C Arter, S Liver, A Leggott, L Trask, G Karageorgis, ...
Synthesis 52 (11), 1695-1706, 2020
72020
Diversity‐Oriented Synthesis of Natural Product–Like Libraries
M Dow, F Marchetti, A Nelson
Diversity‐Oriented Synthesis: Basics and Applications in Organic Synthesis …, 2013
52013
Synthesis of spirocyclic 1, 2-diamines by dearomatising intramolecular diamination of phenols
A Aimon, MJ Dow, AR Hanby, EA Okolo, CM Pask, A Nelson, SP Marsden
Chemical Communications 59 (5), 607-610, 2023
22023
Frontispiece: Activity‐Directed Synthesis with Intermolecular Reactions: Development of a Fragment into a Range of Androgen Receptor Agonists
G Karageorgis, M Dow, A Aimon, S Warriner, A Nelson
Angewandte Chemie International Edition 46 (54), n/a-n/a, 2015
2015
Practical Methods for Biocatalysis and Biotransformations 2
http://onlinelibrary.wiley.com/book/10.1002/9781119943426, 203-229, 2013
2013
Development of methods for the synthesis of natural product-like macrocycles
MJL Dow
University of Leeds, 2012
2012
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Artikler 1–19