| Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease A Douangamath, D Fearon, P Gehrtz, T Krojer, P Lukacik, CD Owen, ... Nature communications 11 (1), 5047, 2020 | 435 | 2020 |
| Sharpless asymmetric aminohydroxylation: scope, limitations, and use in synthesis P O'Brien Angewandte Chemie International Edition 38 (3), 326-329, 1999 | 347 | 1999 |
| A readily-accessible (+)-sparteine surrogate MJ Dearden, CR Firkin, JPR Hermet, P O'Brien Journal of the American Chemical Society 124 (40), 11870-11871, 2002 | 302 | 2002 |
| Synthesis of spirocyclic indolenines MJ James, P O'Brien, RJK Taylor, WP Unsworth Chemistry–A European Journal 22 (9), 2856-2881, 2016 | 279 | 2016 |
| Recent advances in asymmetric synthesis using chiral lithium amide bases P O’Brien Journal of the Chemical Society, Perkin Transactions 1, 1439-1458, 1998 | 238 | 1998 |
| Asymmetric Deprotonation of N-Boc Piperidine: React IR Monitoring and Mechanistic Aspects D Stead, G Carbone, P O’Brien, KR Campos, I Coldham, A Sanderson Journal of the American Chemical Society 132 (21), 7260-7261, 2010 | 181 | 2010 |
| Catalytic Asymmetric Synthesis of Ferrocenes and P-Stereogenic Bisphosphines C Genet, SJ Canipa, P O'Brien, S Taylor Journal of the American Chemical Society 128 (29), 9336-9337, 2006 | 159 | 2006 |
| Enantioselective, Palladium-Catalyzed α-Arylation of N-Boc Pyrrolidine: In Situ React IR Spectroscopic Monitoring, Scope, and Synthetic Applications G Barker, JL McGrath, A Klapars, D Stead, G Zhou, KR Campos, ... The Journal of organic chemistry 76 (15), 5936-5953, 2011 | 155 | 2011 |
| Silver (I)‐or Copper (II)‐Mediated Dearomatization of Aromatic Ynones: Direct Access to Spirocyclic Scaffolds MJ James, JD Cuthbertson, P O'Brien, RJK Taylor, WP Unsworth Angewandte Chemie International Edition 54 (26), 7640-7643, 2015 | 151 | 2015 |
| A New Sparteine Surrogate for Asymmetric Deprotonation of N-Boc Pyrrolidine D Stead, P O'Brien, A Sanderson Organic letters 10 (7), 1409-1412, 2008 | 141 | 2008 |
| Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking M Schuller, GJ Correy, S Gahbauer, D Fearon, T Wu, RE Díaz, ID Young, ... Science advances 7 (16), eabf8711, 2021 | 127 | 2021 |
| Catalyst‐Driven Scaffold Diversity: Selective Synthesis of Spirocycles, Carbazoles and Quinolines from Indolyl Ynones JTR Liddon, MJ James, AK Clarke, P O'Brien, RJK Taylor, WP Unsworth Chemistry–A European Journal 22 (26), 8777-8780, 2016 | 127 | 2016 |
| Silver (I)-catalyzed dearomatization of alkyne-tethered indoles: divergent synthesis of spirocyclic indolenines and carbazoles MJ James, RE Clubley, KY Palate, TJ Procter, AC Wyton, P O’Brien, ... Organic letters 17 (17), 4372-4375, 2015 | 125 | 2015 |
| Catalytic asymmetric deprotonation using a ligand exchange approach MJ McGrath, P O'Brien Journal of the American Chemical Society 127 (47), 16378-16379, 2005 | 124 | 2005 |
| Evaluation of (+)-sparteine-like diamines for asymmetric synthesis MJ Dearden, MJ McGrath, P O'Brien The Journal of organic chemistry 69 (17), 5789-5792, 2004 | 116 | 2004 |
| An Experimental and in Situ IR Spectroscopic Study of the Lithiation–Substitution of N-Boc-2-phenylpyrrolidine and -piperidine: Controlling the Formation of … NS Sheikh, D Leonori, G Barker, JD Firth, KR Campos, AJHM Meijer, ... Journal of the American Chemical Society 134 (11), 5300-5308, 2012 | 115 | 2012 |
| Diamine-Free Lithiation−Trapping of N-Boc Heterocycles using s-BuLi in THF G Barker, P O’Brien, KR Campos Organic letters 12 (18), 4176-4179, 2010 | 108 | 2010 |
| Silica‐Supported Silver Nitrate as a Highly Active Dearomatizing Spirocyclization Catalyst: Synergistic Alkyne Activation by Silver Nanoparticles and Silica AK Clarke, MJ James, P O'Brien, RJK Taylor, WP Unsworth Angewandte Chemie International Edition 55 (44), 13798-13802, 2016 | 107 | 2016 |
| Asymmetric Deprotonation using s-BuLi or i-PrLi and Chiral Diamines in THF: The Diamine Matters G Carbone, P O’Brien, G Hilmersson Journal of the American Chemical Society 132 (43), 15445-15450, 2010 | 104 | 2010 |
| Visible-light-induced intramolecular charge transfer in the radical spirocyclisation of indole-tethered ynones HE Ho, A Pagano, JA Rossi-Ashton, JR Donald, RG Epton, JC Churchill, ... Chemical Science 11 (5), 1353-1360, 2020 | 97 | 2020 |
