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Jayvardhan Pandit
Jayvardhan Pandit
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Identification, characterization, and crystal structure of the Omega class glutathione transferases
PG Board, M Coggan, G Chelvanayagam, S Easteal, LS Jermiin, ...
Journal of Biological Chemistry 275 (32), 24798-24806, 2000
9172000
Three-dimensional structures of the periplasmic lysine/arginine/ornithine-binding protein with and without a ligand
BH Oh, J Pandit, CH Kang, K Nikaido, S Gokcen, GF Ames, SH Kim
Journal of Biological Chemistry 268 (15), 11348-11355, 1993
3931993
Crystal structure of human squalene synthase: a key enzyme in cholesterol biosynthesis
J Pandit, DE Danley, GK Schulte, S Mazzalupo, TA Pauly, CM Hayward, ...
Journal of Biological Chemistry 275 (39), 30610-30617, 2000
3092000
Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl …
PR Verhoest, DS Chapin, M Corman, K Fonseca, JF Harms, X Hou, ...
Journal of medicinal chemistry 52 (16), 5188-5196, 2009
2412009
Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor
J Pandit, A Bohm, J Jancarik, R Halenbeck, K Koths, SH Kim
Science 258 (5086), 1358-1362, 1992
2231992
High-resolution structures of the ligand binding domain of the wild-type bacterial aspartate receptor
JI Yeh, HP Biemann, GG Privé, J Pandit, DE Koshland Jr, SH Kim
Journal of molecular biology 262 (2), 186-201, 1996
2201996
Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct
J Pandit, MD Forman, KF Fennell, KS Dillman, FS Menniti
Proceedings of the National Academy of Sciences 106 (43), 18225-18230, 2009
1662009
Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications
A Maderna, M Doroski, C Subramanyam, A Porte, CA Leverett, ...
Journal of medicinal chemistry 57 (24), 10527-10543, 2014
1452014
The three-dimensional structure of the ligand-binding domain of a wild-type bacterial chemotaxis receptor. Structural comparison to the cross-linked mutant forms and …
JI Yeh, HP Biemann, J Pandit, DE Koshland, SH Kim
Journal of Biological Chemistry 268 (13), 9787-9792, 1993
1441993
Discovery of a series of 6, 7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors
TA Chappie, JM Humphrey, MP Allen, KG Estep, CB Fox, LA Lebel, ...
Journal of medicinal chemistry 50 (2), 182-185, 2007
1432007
Cyclic nucleotide binding GAF domains from phosphodiesterases: structural and mechanistic insights
CC Heikaus, J Pandit, RE Klevit
Structure 17 (12), 1551-1557, 2009
1422009
Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core
VL Rath, M Ammirati, PK LeMotte, KF Fennell, MN Mansour, DE Danley, ...
Molecular cell 6 (1), 139-148, 2000
1352000
Anilinoquinazoline inhibitors of fructose 1, 6-bisphosphatase bind at a novel allosteric site: synthesis, in vitro characterization, and X-ray crystallography
SW Wright, AA Carlo, MD Carty, DE Danley, DL Hageman, GA Karam, ...
Journal of medicinal chemistry 45 (18), 3865-3877, 2002
1152002
Allosteric modulators for the treatment of schizophrenia: targeting glutamatergic networks
F S Menniti, C W Lindsley, P Jeffrey Conn, J Pandit, P Zagouras, ...
Current topics in medicinal chemistry 13 (1), 26-54, 2013
1052013
Synthesis and biological activity of selective pipecolic acid-based TNF-α converting enzyme (TACE) inhibitors
MA Letavic, MZ Axt, JT Barberia, TJ Carty, DE Danley, KF Geoghegan, ...
Bioorganic & medicinal chemistry letters 12 (10), 1387-1390, 2002
992002
Design of selective, ATP-competitive inhibitors of Akt
KD Freeman-Cook, C Autry, G Borzillo, D Gordon, E Barbacci-Tobin, ...
Journal of medicinal chemistry 53 (12), 4615-4622, 2010
962010
Synthesis and structure based optimization of novel Akt inhibitors
B Lippa, G Pan, M Corbett, C Li, GS Kauffman, J Pandit, S Robinson, ...
Bioorganic & medicinal chemistry letters 18 (11), 3359-3363, 2008
962008
Theoretical and experimental design of atypical kinase inhibitors: application to p38 MAP kinase
KF McClure, YA Abramov, ER Laird, JT Barberia, W Cai, TJ Carty, ...
Journal of medicinal chemistry 48 (18), 5728-5737, 2005
952005
Crystal structure of 3', 5'-cyclic nucleotide phosphodiesterase (PDE1B) and uses thereof
J Pandit
US Patent App. 10/815,390, 2005
922005
A novel binding mode reveals two distinct classes of NMDA receptor GluN2B-selective antagonists
D Stroebel, DL Buhl, JD Knafels, PK Chanda, M Green, S Sciabola, ...
Molecular pharmacology 89 (5), 541-551, 2016
912016
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