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Shuying Sun
Shuying Sun
Assistant Professor, Johns Hopkins University School of Medicine
Verified email at jhmi.edu - Homepage
Title
Cited by
Cited by
Year
Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration
C Lagier-Tourenne, M Baughn, F Rigo, S Sun, P Liu, HR Li, J Jiang, ...
Proceedings of the National Academy of Sciences 110 (47), E4530-E4539, 2013
6532013
Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
A Jovičić, J Mertens, S Boeynaems, E Bogaert, N Chai, SB Yamada, ...
Nature neuroscience 18 (9), 1226-1229, 2015
6192015
Gain of toxicity from ALS/FTD-linked repeat expansions in C9ORF72 is alleviated by antisense oligonucleotides targeting GGGGCC-containing RNAs
J Jiang, Q Zhu, TF Gendron, S Saberi, M McAlonis-Downes, A Seelman, ...
Neuron 90 (3), 535-550, 2016
5492016
HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism
SM Weyn-Vanhentenryck, A Mele, Q Yan, S Sun, N Farny, Z Zhang, ...
Cell reports 6 (6), 1139-1152, 2014
3612014
Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2
C Zhang, Z Zhang, J Castle, S Sun, J Johnson, AR Krainer, MQ Zhang
Genes & development 22 (18), 2550-2563, 2008
3352008
SRSF1-regulated alternative splicing in breast cancer
O Anczuków, M Akerman, A Cléry, J Wu, C Shen, NH Shirole, A Raimer, ...
Molecular cell 60 (1), 105-117, 2015
3202015
ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP
S Sun, SC Ling, J Qiu, CP Albuquerque, Y Zhou, S Tokunaga, H Li, H Qiu, ...
Nature communications 6 (1), 6171, 2015
2402015
A splicing-independent function of SF2/ASF in microRNA processing
H Wu, S Sun, K Tu, Y Gao, B Xie, AR Krainer, J Zhu
Molecular cell 38 (1), 67-77, 2010
2322010
SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control
S Sun, Z Zhang, R Sinha, R Karni, AR Krainer
Nature structural & molecular biology 17 (3), 306-312, 2010
2262010
C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation
W Cheng, S Wang, AA Mestre, C Fu, A Makarem, F Xian, LR Hayes, ...
Nature communications 9 (1), 51, 2018
1822018
Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS
S Sun, Y Sun, SC Ling, L Ferraiuolo, M McAlonis-Downes, Y Zou, ...
Proceedings of the National Academy of Sciences 112 (50), E6993-E7002, 2015
1802015
Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1
A Israelson, D Ditsworth, S Sun, SW Song, J Liang, M Hruska-Plochan, ...
Neuron 86 (1), 218-232, 2015
1232015
SpliceTrap: a method to quantify alternative splicing under single cellular conditions
J Wu, M Akerman, S Sun, WR McCombie, AR Krainer, MQ Zhang
Bioinformatics 27 (21), 3010-3016, 2011
1172011
CRISPR-Cas9 screens identify the RNA helicase DDX3X as a repressor of C9ORF72 (GGGGCC) n repeat-associated non-AUG translation
W Cheng, S Wang, Z Zhang, DW Morgens, LR Hayes, S Lee, B Portz, ...
Neuron 104 (5), 885-898. e8, 2019
1122019
Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2
S Sun, ZUO Zhang, O Fregoso, AR Krainer
Rna 18 (2), 274-283, 2012
1042012
PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel
J Yang, J Chen, M del Carmen Vitery, J Osei-Owusu, J Chu, H Yu, S Sun, ...
Science 364 (6438), 395-399, 2019
962019
Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis
SC Ling, SG Dastidar, S Tokunaga, WY Ho, K Lim, H Ilieva, PA Parone, ...
elife 8, e40811, 2019
732019
Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis
D Ditsworth, M Maldonado, M McAlonis-Downes, S Sun, A Seelman, ...
Acta neuropathologica 133, 907-922, 2017
672017
Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD
S Wang, MJ Latallo, Z Zhang, B Huang, DG Bobrovnikov, D Dong, ...
Nature communications 12 (1), 4908, 2021
502021
UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction
BL Zaepfel, Z Zhang, K Maulding, AN Coyne, W Cheng, LR Hayes, ...
Cell reports 34 (13), 2021
182021
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