Jurian Schuijers
Jurian Schuijers
Assistant Professor at Center for Molecular Medicine, UMC Utrecht
Verifisert e-postadresse på umcutrecht.nl - Startside
Sitert av
Sitert av
Coactivator condensation at super-enhancers links phase separation and gene control
BR Sabari, A Dall’Agnese, A Boija, IA Klein, EL Coffey, K Shrinivas, ...
Science 361 (6400), eaar3958, 2018
Transcription factors activate genes through the phase-separation capacity of their activation domains
A Boija, IA Klein, BR Sabari, A Dall’Agnese, EL Coffey, AV Zamudio, ...
Cell 175 (7), 1842-1855. e16, 2018
Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes
JM Dowen, ZP Fan, D Hnisz, G Ren, BJ Abraham, LN Zhang, ...
Cell 159 (2), 374-387, 2014
Unlimited in vitro expansion of adult bi‐potent pancreas progenitors through the Lgr5/R‐spondin axis
M Huch, P Bonfanti, SF Boj, T Sato, CJM Loomans, M Van De Wetering, ...
The EMBO journal 32 (20), 2708-2721, 2013
Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers
D Hnisz, J Schuijers, CY Lin, AS Weintraub, BJ Abraham, TI Lee, ...
Molecular cell 58 (2), 362-370, 2015
Adult mammalian stem cells: the role of Wnt, Lgr5 and R‐spondins
J Schuijers, H Clevers
The EMBO journal 31 (12), 2685-2696, 2012
Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts
J Schuijers, JP Junker, M Mokry, P Hatzis, BK Koo, V Sasselli, ...
Cell stem cell 16 (2), 158-170, 2015
Enhancer features that drive formation of transcriptional condensates
K Shrinivas, BR Sabari, EL Coffey, IA Klein, A Boija, AV Zamudio, ...
Molecular cell 75 (3), 549-561. e7, 2019
Wnt‐induced transcriptional activation is exclusively mediated by TCF/LEF
J Schuijers, M Mokry, P Hatzis, E Cuppen, H Clevers
The EMBO journal 33 (2), 146-156, 2014
Mediator condensates localize signaling factors to key cell identity genes
AV Zamudio, A Dall’Agnese, JE Henninger, JC Manteiga, LK Afeyan, ...
Molecular cell 76 (5), 753-766. e6, 2019
Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism
J Schuijers, JC Manteiga, AS Weintraub, DS Day, AV Zamudio, D Hnisz, ...
Cell reports 23 (2), 349-360, 2018
DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus
LTJ Kaaij, M van de Wetering, F Fang, B Decato, A Molaro, ...
Genome biology 14 (5), 1-15, 2013
Robust cre-mediated recombination in small intestinal stem cells utilizing the olfm4 locus
J Schuijers, LG van der Flier, J van Es, H Clevers
Stem cell reports 3 (2), 234-241, 2014
Integrated genome-wide analysis of transcription factor occupancy, RNA polymerase II binding and steady-state RNA levels identify differentially regulated functional gene classes
M Mokry, P Hatzis, J Schuijers, N Lansu, FP Ruzius, H Clevers, E Cuppen
Nucleic acids research 40 (1), 148-158, 2012
TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions
MP Verzi, P Hatzis, R Sulahian, J Philips, J Schuijers, H Shin, E Freed, ...
Proceedings of the National Academy of Sciences 107 (34), 15157-15162, 2010
MeCP2 links heterochromatin condensates and neurodevelopmental disease
CH Li, EL Coffey, A Dall’Agnese, NM Hannett, X Tang, JE Henninger, ...
Nature 586 (7829), 440-444, 2020
Efficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profiles
M Mokry, P Hatzis, E De Bruijn, J Koster, R Versteeg, J Schuijers, ...
PloS one 5 (11), e15092, 2010
Regulation and dysregulation of chromosome structure in cancer
D Hnisz, J Schuijers, CH Li, RA Young
Annual Review of Cancer Biology 2, 21-40, 2018
Methods and assays for modulating gene transcription by modulating condensates
RA Young, PA Sharp, AK Chakraborty, A Dall'Agnese, K Shrinivas, ...
US Patent App. 17/040,967, 2022
Protein Condensation in the Nuclear Receptor Family; Implications for Transcriptional Output
MD Appelman, EE Hollaar, J Schuijers, SWC van Mil
Nuclear Receptors in Human Health and Disease, 243-253, 2022
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Artikler 1–20