Graham Searle
Graham Searle
Invicro
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Imaging dopamine receptors in humans with [11C]-(+)-PHNO: dissection of D3 signal and anatomy
AC Tziortzi, GE Searle, S Tzimopoulou, C Salinas, JD Beaver, ...
Neuroimage 54 (1), 264-277, 2011
3092011
Connectivity-based functional analysis of dopamine release in the striatum using diffusion-weighted MRI and positron emission tomography
AC Tziortzi, SN Haber, GE Searle, C Tsoumpas, CJ Long, P Shotbolt, ...
Cerebral cortex 24 (5), 1165-1177, 2014
1662014
Imaging dopamine D3 receptors in the human brain with positron emission tomography,[11C] PHNO, and a selective D3 receptor antagonist
G Searle, JD Beaver, RA Comley, M Bani, A Tziortzi, M Slifstein, ...
Biological psychiatry 68 (4), 392-399, 2010
1392010
Within-Subject Comparison of [11C]-( + )-PHNO and [11C]raclopride Sensitivity to Acute Amphetamine Challenge in Healthy Humans
P Shotbolt, AC Tziortzi, GE Searle, A Colasanti, J Van Der Aart, ...
Journal of Cerebral Blood Flow & Metabolism 32 (1), 127-136, 2012
1162012
Within-Subject Comparison of [11C]-( + )-PHNO and [11C]raclopride Sensitivity to Acute Amphetamine Challenge in Healthy Humans
P Shotbolt, AC Tziortzi, GE Searle, A Colasanti, J Van Der Aart, ...
Journal of Cerebral Blood Flow & Metabolism 32 (1), 127-136, 2012
1162012
Positron emission tomography imaging of amphetamine‐induced dopamine release in the human cortex: A comparative evaluation of the high affinity dopamine D2/3 radiotracers [11C …
R Narendran, WG Frankle, NS Mason, EA Rabiner, RN Gunn, GE Searle, ...
Synapse 63 (6), 447-461, 2009
1122009
Endogenous opioid release in the human brain reward system induced by acute amphetamine administration
A Colasanti, GE Searle, CJ Long, SP Hill, RR Reiley, D Quelch, D Erritzoe, ...
Biological psychiatry 72 (5), 371-377, 2012
842012
Pharmacological differentiation of opioid receptor antagonists by molecular and functional imaging of target occupancy and food reward-related brain activation in humans
EA Rabiner, J Beaver, A Makwana, G Searle, C Long, PJ Nathan, ...
Molecular psychiatry 16 (8), 826-835, 2011
832011
Pharmacological differentiation of opioid receptor antagonists by molecular and functional imaging of target occupancy and food reward-related brain activation in humans
EA Rabiner, J Beaver, A Makwana, G Searle, C Long, PJ Nathan, ...
Molecular psychiatry 16 (8), 826-835, 2011
802011
A multi-center randomized proof-of-concept clinical trial applying [18F] FDG-PET for evaluation of metabolic therapy with rosiglitazone XR in mild to moderate Alzheimer's disease
S Tzimopoulou, VJ Cunningham, TE Nichols, G Searle, NP Bird, P Mistry, ...
Journal of Alzheimer's Disease 22 (4), 1241-1256, 2010
722010
A multi-center randomized proof-of-concept clinical trial applying [18F] FDG-PET for evaluation of metabolic therapy with rosiglitazone XR in mild to moderate Alzheimer's disease
S Tzimopoulou, VJ Cunningham, TE Nichols, G Searle, NP Bird, P Mistry, ...
Journal of Alzheimer's Disease 22 (4), 1241-1256, 2010
722010
The simplified reference tissue model: model assumption violations and their impact on binding potential
CA Salinas, GE Searle, RN Gunn
Journal of Cerebral Blood Flow & Metabolism 35 (2), 304-311, 2015
682015
Loss of phosphodiesterase 10A expression is associated with progression and severity in Parkinson’s disease
F Niccolini, T Foltynie, T Reis Marques, N Muhlert, AC Tziortzi, GE Searle, ...
Brain 138 (10), 3003-3015, 2015
662015
Altered PDE10A expression detectable early before symptomatic onset in Huntington’s disease
F Niccolini, S Haider, T Reis Marques, N Muhlert, AC Tziortzi, GE Searle, ...
Brain 138 (10), 3016-3029, 2015
652015
Application of a generic physiologically based pharmacokinetic model to the estimation of xenobiotic levels in human plasma
FA Brightman, DE Leahy, GE Searle, S Thomas
Drug metabolism and disposition 34 (1), 94-101, 2006
612006
Orbitofrontal connectivity with resting-state networks is associated with midbrain dopamine D3 receptor availability
DM Cole, CF Beckmann, GE Searle, C Plisson, AC Tziortzi, TE Nichols, ...
Cerebral cortex 22 (12), 2784-2793, 2012
582012
Blunted endogenous opioid release following an oral amphetamine challenge in pathological gamblers
I Mick, J Myers, AC Ramos, PRA Stokes, D Erritzoe, A Colasanti, ...
Neuropsychopharmacology 41 (7), 1742-1750, 2016
502016
In vivo imaging of cerebral dopamine D3 receptors in alcoholism
D Erritzoe, A Tziortzi, D Bargiela, A Colasanti, GE Searle, RN Gunn, ...
Neuropsychopharmacology 39 (7), 1703-1712, 2014
492014
Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy
S Abanades, J Van Der Aart, JAR Barletta, C Marzano, GE Searle, ...
Journal of Cerebral Blood Flow & Metabolism 31 (3), 944-952, 2011
472011
Kinetic analysis of the translocator protein positron emission tomography ligand [18F]GE-180 in the human brain
C Feeney, G Scott, J Raffel, S Roberts, C Coello, A Jolly, G Searle, ...
European journal of nuclear medicine and molecular imaging 43 (12), 2201-2210, 2016
462016
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