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Michael L. Stitzel
Michael L. Stitzel
Associate Professor, The Jackson Laboratory for Genomic Medicine
Verifisert e-postadresse på jax.org
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The genetic architecture of type 2 diabetes
C Fuchsberger, J Flannick, TM Teslovich, A Mahajan, V Agarwala, ...
Nature 536 (7614), 41-47, 2016
12392016
Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants
SCJ Parker, ML Stitzel, DL Taylor, JM Orozco, MR Erdos, JA Akiyama, ...
Proceedings of the National Academy of Sciences 110 (44), 17921-17926, 2013
6902013
Single-cell transcriptomes identify human islet cell signatures and reveal cell-type–specific expression changes in type 2 diabetes
N Lawlor, J George, M Bolisetty, R Kursawe, L Sun, V Sivakamasundari, ...
Genome research 27 (2), 208-222, 2017
4642017
Regulation of the oocyte-to-zygote transition
ML Stitzel, G Seydoux
Science 316 (5823), 407-408, 2007
3192007
Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci
ML Stitzel, P Sethupathy, DS Pearson, PS Chines, L Song, MR Erdos, ...
Cell metabolism 12 (5), 443-455, 2010
2292010
Targeted disruption of the methionine synthase gene in mice
DA Swanson, ML Liu, PJ Baker, L Garrett, M Stitzel, J Wu, M Harris, ...
Molecular and cellular biology 21 (4), 1058-1065, 2001
2072001
Genetic regulatory signatures underlying islet gene expression and type 2 diabetes
A Varshney, LJ Scott, RP Welch, MR Erdos, PS Chines, N Narisu, ...
Proceedings of the National Academy of Sciences 114 (9), 2301-2306, 2017
2002017
Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma
JJ Gartner, SCJ Parker, TD Prickett, K Dutton-Regester, ML Stitzel, JC Lin, ...
Proceedings of the National Academy of Sciences 110 (33), 13481-13486, 2013
1982013
Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes
AR Majithia, J Flannick, P Shahinian, M Guo, MA Bray, P Fontanillas, ...
Proceedings of the National Academy of Sciences 111 (36), 13127-13132, 2014
1762014
The chromatin accessibility signature of human immune aging stems from CD8+ T cells
D Ucar, EJ Márquez, CH Chung, R Marches, RJ Rossi, A Uyar, TC Wu, ...
Journal of Experimental Medicine 214 (10), 3123-3144, 2017
1542017
Autosomal dominant diabetes arising from a Wolfram syndrome 1 mutation
LL Bonnycastle, PS Chines, T Hara, JR Huyghe, AJ Swift, P Heikinheimo, ...
Diabetes 62 (11), 3943-3950, 2013
1232013
The C. elegans DYRK kinase MBK-2 marks oocyte proteins for degradation in response to meiotic maturation
ML Stitzel, J Pellettieri, G Seydoux
Current Biology 16 (1), 56-62, 2006
1232006
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D
A Viñuela, A Varshney, M van de Bunt, RB Prasad, O Asplund, A Bennett, ...
Nature communications 11 (1), 4912, 2020
1012020
A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell
JR Kulzer, ML Stitzel, MA Morken, JR Huyghe, C Fuchsberger, J Kuusisto, ...
The American Journal of Human Genetics 94 (2), 186-197, 2014
952014
National Institutes of Health Intramural Sequencing Center Comparative Sequencing Program Authors; NISC Comparative Sequencing Program Authors (2013). Chromatin stretch …
SC Parker, ML Stitzel, DL Taylor, JM Orozco, MR Erdos, JA Akiyama, ...
Proc. Natl. Acad. Sci. USA 110, 17921-17926, 0
80
Regulation of MBK-2/Dyrk kinase by dynamic cortical anchoring during the oocyte-to-zygote transition
ML Stitzel, KCC Cheng, G Seydoux
Current Biology 17 (18), 1545-1554, 2007
702007
Multiomic profiling identifies cis-regulatory networks underlying human pancreatic β cell identity and function
N Lawlor, EJ Marquez, P Orchard, N Narisu, MS Shamim, A Thibodeau, ...
Cell reports 26 (3), 788-801. e6, 2019
692019
Type 2 diabetes–associated genetic variants regulate chromatin accessibility in human islets
S Khetan, R Kursawe, A Youn, N Lawlor, A Jillette, EJ Marquez, D Ucar, ...
Diabetes 67 (11), 2466-2477, 2018
692018
Genomics of islet (dys) function and type 2 diabetes
N Lawlor, S Khetan, D Ucar, ML Stitzel
Trends in Genetics 33 (4), 244-255, 2017
692017
A Type 2 Diabetes–Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus
TS Roman, ME Cannon, S Vadlamudi, ML Buchkovich, BN Wolford, ...
Diabetes 66 (9), 2521-2530, 2017
642017
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