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Benjamin Hackel
Benjamin Hackel
Verifisert e-postadresse på umn.edu - Startside
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Isolating and engineering human antibodies using yeast surface display
G Chao, WL Lau, BJ Hackel, SL Sazinsky, SM Lippow, KD Wittrup
Nature protocols 1 (2), 755-768, 2006
11042006
Picomolar affinity fibronectin domains engineered utilizing loop length diversity, recursive mutagenesis, and loop shuffling
BJ Hackel, A Kapila, KD Wittrup
Journal of molecular biology 381 (5), 1238-1252, 2008
2722008
Evolution of an interloop disulfide bond in high-affinity antibody mimics based on fibronectin type III domain and selected by yeast surface display: molecular convergence with …
D Lipovšek, SM Lippow, BJ Hackel, MW Gregson, P Cheng, A Kapila, ...
Journal of molecular biology 368 (4), 1024-1041, 2007
1762007
Fmoc-based synthesis of peptide α-thioesters using an aryl hydrazine support
JA Camarero, BJ Hackel, JJ De Yoreo, AR Mitchell
The Journal of organic chemistry 69 (12), 4145-4151, 2004
1672004
Stability and CDR composition biases enrich binder functionality landscapes
BJ Hackel, ME Ackerman, SW Howland, KD Wittrup
Journal of molecular biology 401 (1), 84-96, 2010
1392010
Pharmacokinetically stabilized cystine knot peptides that bind alpha-v-beta-6 integrin with single-digit nanomolar affinities for detection of pancreatic cancer
RH Kimura, R Teed, BJ Hackel, MA Pysz, CZ Chuang, A Sathirachinda, ...
Clinical Cancer Research 18 (3), 839-849, 2012
1292012
Photoacoustic lifetime contrast between methylene blue monomers and self-quenched dimers as a model for dual-labeled activatable probes
E Morgounova, Q Shao, BJ Hackel, DD Thomas, S Ashkenazi
Journal of biomedical optics 18 (5), 056004-056004, 2013
1162013
Highly avid magnetic bead capture: an efficient selection method for de novo protein engineering utilizing yeast surface display
M Ackerman, D Levary, G Tobon, B Hackel, KD Orcutt, KD Wittrup
Biotechnology progress 25 (3), 774-783, 2009
1162009
Convergent potency of internalized gelonin immunotoxins across varied cell lines, antigens, and targeting moieties
CM Pirie, BJ Hackel, MG Rosenblum, KD Wittrup
Journal of Biological Chemistry 286 (6), 4165-4172, 2011
1022011
Production of Soluble and Active Transferrin Receptor-Targeting Single-Chain Antibody using Saccharomyces cerevisiae
BJ Hackel, D Huang, JC Bubolz, XX Wang, EV Shusta
Pharmaceutical research 23, 790-797, 2006
962006
Alternative non-antibody protein scaffolds for molecular imaging of cancer
LA Stern, BA Case, BJ Hackel
Current opinion in chemical engineering 2 (4), 425-432, 2013
862013
Use of 64Cu-labeled Fibronectin Domain with EGFR-Overexpressing Tumor Xenograft: Molecular Imaging
BJ Hackel, RH Kimura, SS Gambhir
Radiology 263 (1), 179-188, 2012
842012
Multivalent ligand binding to cell membrane antigens: defining the interplay of affinity, valency, and expression density
CM Csizmar, JR Petersburg, TJ Perry, L Rozumalski, BJ Hackel, ...
Journal of the American Chemical Society 141 (1), 251-261, 2018
772018
A 45-amino-acid scaffold mined from the PDB for high-affinity ligand engineering
MA Kruziki, S Bhatnagar, DR Woldring, VT Duong, BJ Hackel
Chemistry & biology 22 (7), 946-956, 2015
692015
A novel engineered anti-CD20 tracer enables early time PET imaging in a humanized transgenic mouse model of B-cell non-Hodgkins lymphoma
A Natarajan, BJ Hackel, SS Gambhir
Clinical Cancer Research 19 (24), 6820-6829, 2013
682013
18F-Fluorobenzoate–labeled cystine knot peptides for PET imaging of integrin αvβ6
BJ Hackel, RH Kimura, Z Miao, H Liu, A Sathirachinda, Z Cheng, FT Chin, ...
Journal of Nuclear Medicine 54 (7), 1101-1105, 2013
682013
Engineering fibronectin-based binding proteins by yeast surface display
TF Chen, S De Picciotto, BJ Hackel, KD Wittrup
Methods in enzymology 523, 303-326, 2013
662013
Engineered proteins including mutant fibronectin domains
KD Wittrup, JB Spangler, BJ Hackel
US Patent App. 13/390,086, 2012
592012
The full amino acid repertoire is superior to serine/tyrosine for selection of high affinity immunoglobulin G binders from the fibronectin scaffold
BJ Hackel, KD Wittrup
Protein Engineering, Design & Selection 23 (4), 211-219, 2010
542010
High-throughput ligand discovery reveals a sitewise gradient of diversity in broadly evolved hydrophilic fibronectin domains
DR Woldring, PV Holec, H Zhou, BJ Hackel
PLoS One 10 (9), e0138956, 2015
512015
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Artikler 1–20