| Mitochondrially targeted ZFN s for selective degradation of pathogenic mitochondrial genomes bearing large‐scale deletions or point mutations PA Gammage, J Rorbach, AI Vincent, EJ Rebar, M Minczuk EMBO molecular medicine 6 (4), 458-466, 2014 | 300 | 2014 |
| Mitochondrial genome engineering: the revolution may not be CRISPR-Ized PA Gammage, CT Moraes, M Minczuk Trends in Genetics 34 (2), 101-110, 2018 | 288 | 2018 |
| Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo PA Gammage, C Viscomi, ML Simard, ASH Costa, E Gaude, CA Powell, ... Nature medicine 24 (11), 1691-1695, 2018 | 263 | 2018 |
| NADH shuttling couples cytosolic reductive carboxylation of glutamine with glycolysis in cells with mitochondrial dysfunction E Gaude, C Schmidt, PA Gammage, A Dugourd, T Blacker, SP Chew, ... Molecular cell 69 (4), 581-593. e7, 2018 | 214 | 2018 |
| Linear mitochondrial DNA is rapidly degraded by components of the replication machinery V Peeva, D Blei, G Trombly, S Corsi, MJ Szukszto, P Rebelo-Guiomar, ... Nature communications 9 (1), 1727, 2018 | 184 | 2018 |
| Mitochondrial DNA: the overlooked oncogenome? PA Gammage, C Frezza BMC biology 17 (1), 53, 2019 | 135 | 2019 |
| MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome J Rorbach, P Boesch, PA Gammage, TJJ Nicholls, SF Pearce, D Patel, ... Molecular biology of the cell 25 (17), 2542-2555, 2014 | 122 | 2014 |
| Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs PA Gammage, E Gaude, L Van Haute, P Rebelo-Guiomar, CB Jackson, ... Nucleic acids research 44 (16), 7804-7816, 2016 | 116 | 2016 |
| C7orf30 is necessary for biogenesis of the large subunit of the mitochondrial ribosome J Rorbach, PA Gammage, M Minczuk Nucleic Acids Research 40 (9), 4097-4109, 2012 | 84 | 2012 |
| Alternative translation initiation augments the human mitochondrial proteome L Kazak, A Reyes, AL Duncan, J Rorbach, SR Wood, G Brea-Calvo, ... Nucleic acids research 41 (4), 2354-2369, 2013 | 68 | 2013 |
| Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA AN Gorelick, M Kim, WK Chatila, K La, AA Hakimi, MF Berger, BS Taylor, ... Nature metabolism 3 (4), 558-570, 2021 | 61 | 2021 |
| PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness N Rabas, S Palmer, L Mitchell, S Ismail, A Gohlke, JS Riley, SWG Tait, ... Journal of Cell Biology 220 (12), e202006049, 2021 | 57 | 2021 |
| Therapeutic manipulation of mtDNA heteroplasmy: a shifting perspective CB Jackson, DM Turnbull, M Minczuk, PA Gammage Trends in molecular medicine 26 (7), 698-709, 2020 | 57 | 2020 |
| Engineered mtZFNs for manipulation of human mitochondrial DNA heteroplasmy PA Gammage, L Van Haute, M Minczuk Mitochondrial DNA: Methods and Protocols, 145-162, 2016 | 43 | 2016 |
| Mitochondrial DNA is a major source of driver mutations in cancer M Kim, M Mahmood, E Reznik, PA Gammage Trends in cancer 8 (12), 1046-1059, 2022 | 30 | 2022 |
| Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila S Andreazza, CL Samstag, A Sanchez-Martinez, E Fernandez-Vizarra, ... Nature communications 10 (1), 3280, 2019 | 30 | 2019 |
| Energetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations H Hoitzing, PA Gammage, LV Haute, M Minczuk, IG Johnston, NS Jones PLoS computational biology 15 (6), e1007023, 2019 | 26* | 2019 |
| Heterozygous SSBP1 start loss mutation co-segregates with hearing loss and the m.1555A>G mtDNA variant in a large multigenerational family PJ Kullar, A Gomez-Duran, PA Gammage, C Garone, M Minczuk, ... Brain 141 (1), 55-62, 2018 | 25 | 2018 |
| Manipulation of mitochondrial genes and mtDNA heteroplasmy SR Bacman, PA Gammage, M Minczuk, CT Moraes Methods in cell biology 155, 441-487, 2020 | 22 | 2020 |
| Mitonuclear genotype remodels the metabolic and microenvironmental landscape of Hürthle cell carcinoma I Ganly, EM Liu, F Kuo, V Makarov, Y Dong, J Park, Y Gong, AN Gorelick, ... Science advances 8 (25), eabn9699, 2022 | 13 | 2022 |
