Leo James
Leo James
MRC Laboratory of Molecular Biology
Verifisert e-postadresse på mrc-lmb.cam.ac.uk
Sitert av
Sitert av
SARS-CoV-2 B. 1.617. 2 Delta variant replication and immune evasion
P Mlcochova, SA Kemp, MS Dhar, G Papa, B Meng, IATM Ferreira, R Datir, ...
Nature 599 (7883), 114-119, 2021
Antibody multispecificity mediated by conformational diversity
LC James, P Roversi, DS Tawfik
Science 299 (5611), 1362-1367, 2003
Conformational diversity and protein evolution–a 60-year-old hypothesis revisited
LC James, DS Tawfik
Trends in biochemical sciences 28 (7), 361-368, 2003
HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency
T Schaller, KE Ocwieja, J Rasaiyaah, AJ Price, TL Brady, SL Roth, S Hué, ...
PLoS pathogens 7 (12), e1002439, 2011
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
B Meng, A Abdullahi, IATM Ferreira, N Goonawardane, A Saito, I Kimura, ...
Nature 603 (7902), 706-714, 2022
HIV-1 evades innate immune recognition through specific cofactor recruitment
J Rasaiyaah, CP Tan, AJ Fletcher, AJ Price, C Blondeau, L Hilditch, ...
Nature 503 (7476), 402-405, 2013
Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)
DL Mallery, WA McEwan, SR Bidgood, GJ Towers, CM Johnson, ...
Proceedings of the National Academy of Sciences 107 (46), 19985-19990, 2010
Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function
LC James, AH Keeble, Z Khan, DA Rhodes, J Trowsdale
Proceedings of the National Academy of Sciences 104 (15), 6200-6205, 2007
SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF barrier in human brain organoids
L Pellegrini, A Albecka, DL Mallery, MJ Kellner, D Paul, AP Carter, ...
Cell stem cell 27 (6), 951-961. e5, 2020
A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex
LP Jackson, BT Kelly, AJ McCoy, T Gaffry, LC James, BM Collins, ...
Cell 141 (7), 1220-1229, 2010
Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21
WA McEwan, JCH Tam, RE Watkinson, SR Bidgood, DL Mallery, ...
Nature immunology 14 (4), 327-336, 2013
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B. 1.1. 7
B Meng, SA Kemp, G Papa, R Datir, IATM Ferreira, S Marelli, WT Harvey, ...
Cell reports 35 (13), 109292, 2021
A method for the acute and rapid degradation of endogenous proteins
D Clift, WA McEwan, LI Labzin, V Konieczny, B Mogessie, LC James, ...
Cell 171 (7), 1692-1706. e18, 2017
CPSF6 defines a conserved capsid interface that modulates HIV-1 replication
AJ Price, AJ Fletcher, T Schaller, T Elliott, KE Lee, VN KewalRamani, ...
Public Library of Science 8 (8), e1002896, 2012
HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2
KE Ocwieja, TL Brady, K Ronen, A Huegel, SL Roth, T Schaller, ...
PLoS pathogens 7 (3), e1001313, 2011
Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion
G Papa, DL Mallery, A Albecka, LG Welch, J Cattin-Ortolá, J Luptak, ...
PLoS pathogens 17 (1), e1009246, 2021
Cellular self-defense: how cell-autonomous immunity protects against pathogens
F Randow, JD MacMicking, LC James
Science 340 (6133), 701-706, 2013
Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly
AJ Price, DA Jacques, WA McEwan, AJ Fletcher, S Essig, JW Chin, ...
PLoS pathogens 10 (10), e1004459, 2014
Recurrent emergence and transmission of a SARS-CoV-2 spike deletion H69/V70
SA Kemp, B Meng, IA Ferriera, R Datir, WT Harvey, G Papa, S Lytras, ...
BioRxiv, 2020.12. 14.422555, 2020
A thermostable, closed SARS-CoV-2 spike protein trimer
X Xiong, K Qu, KA Ciazynska, M Hosmillo, AP Carter, S Ebrahimi, Z Ke, ...
Nature structural & molecular biology 27 (10), 934-941, 2020
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