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Shubham Khetan
Shubham Khetan
Research Fellow, Harvard
Verifisert e-postadresse på bwh.harvard.edu
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Type 2 diabetes–associated genetic variants regulate chromatin accessibility in human islets
S Khetan, R Kursawe, A Youn, N Lawlor, A Jillette, EJ Marquez, D Ucar, ...
Diabetes 67 (11), 2466-2477, 2018
692018
Genomics of islet (dys) function and type 2 diabetes
N Lawlor, S Khetan, D Ucar, ML Stitzel
Trends in Genetics 33 (4), 244-255, 2017
692017
A common type 2 diabetes risk variant potentiates activity of an evolutionarily conserved islet stretch enhancer and increases C2CD4A and C2CD4B expression
I Kycia, BN Wolford, JR Huyghe, C Fuchsberger, S Vadlamudi, R Kursawe, ...
The American Journal of Human Genetics 102 (4), 620-635, 2018
452018
A neural network based model effectively predicts enhancers from clinical ATAC-seq samples
A Thibodeau, A Uyar, S Khetan, ML Stitzel, D Ucar
Scientific reports 8 (1), 16048, 2018
272018
Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation
S Khetan, S Kales, R Kursawe, A Jillette, JC Ulirsch, SK Reilly, D Ucar, ...
Nature communications 12 (1), 5242, 2021
142021
CoRE-ATAC: A deep learning model for the functional classification of regulatory elements from single cell and bulk ATAC-seq data
A Thibodeau, S Khetan, A Eroglu, R Tewhey, ML Stitzel, D Ucar
PLoS Computational Biology 17 (12), e1009670, 2021
122021
Chromatin accessibility profiling uncovers genetic- and T2D disease state-associated changes in cis-regulatory element use in human islets
S Khetan, R Kursawe, A Youn, N Lawlor, EM Campos, D Ucar, ML Stitzel
BioRxiv, 192922, 2017
32017
Functional characterization of thousands of type 2 diabetes-associated and chromatin-modulating variants under steady state and endoplasmic reticulum stress
S Khetan, S Kales, R Kursawe, A Jillette, SK Reilly, D Ucar, R Tewhey, ...
bioRxiv, 2020.02. 12.939348, 2020
12020
Overlapping binding sites underlie TF genomic occupancy
S Khetan, ML Bulyk
bioRxiv, 2024.03. 05.583629, 2024
2024
Deciphering Type 2 Diabetes-associated SNP Effects on Islet Chromatin Accessibility and Beta Cell Expression Levels Using Functional Genomics
S Khetan
2020
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Artikler 1–10