William A McEwan

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Leo JamesMRC Laboratory of Molecular BiologyVerifisert e-postadresse på mrc-lmb.cam.ac.uk
Donna MalleryVerifisert e-postadresse på mrc-lmb.cam.ac.uk
Dean CliftMRC Laboratory of Molecular BiologyVerifisert e-postadresse på mrc-lmb.cam.ac.uk
Greg Towersuniversity college londonVerifisert e-postadresse på ucl.ac.uk
David JacquesSingle Molecule Science, University of New South Wales, AustraliaVerifisert e-postadresse på unsw.edu.au
Jerry C H TamPostdoctoral Researcher at King’s College LondonVerifisert e-postadresse på kcl.ac.uk
Ruth E WatkinsonResearch Fellow, University of ManchesterVerifisert e-postadresse på manchester.ac.uk
Michel GoedertMRC Laboratory of Molecular Biology, Cambridge, UKVerifisert e-postadresse på mrc-lmb.cam.ac.uk
Benjamin TuckPhD StudentVerifisert e-postadresse på cam.ac.uk
Margaret J HosieProfessor of Comparative Virology, University of GlasgowVerifisert e-postadresse på glasgow.ac.uk
Claire F DicksonUNSWVerifisert e-postadresse på unsw.edu.au
Benjamin Ryskeldi-FalconGroup Leader, MRC Laboratory of Molecular Biology (LMB)Verifisert e-postadresse på mrc-lmb.cam.ac.uk
Binyam MogessieYale UniversityVerifisert e-postadresse på yale.edu
Larisa LabzinInstitute for Molecular Bioscience, University of Queensland.Verifisert e-postadresse på uq.edu.au
Upul Deepthike Halambage (Halamba...Aprecia Pharmaceuticals, LLCVerifisert e-postadresse på aprecia.com
Adam J. FletcherMRC University of Glasgow Centre for Virus ResearchVerifisert e-postadresse på glasgow.ac.uk
H.H. KampingaProfessor in Cell BiologyVerifisert e-postadresse på rug.nl
Carmen Nussbaum-KrammerLudwig-Maximilians-UniversityVerifisert e-postadresse på med.uni-muenchen.de
Till BöckingUniversity of New South Wales, Sydney, AustraliaVerifisert e-postadresse på unsw.edu.au
Chantal L MárquezPostdoctoral fellow en Universidad de ChileVerifisert e-postadresse på unsw.edu.au

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William A McEwan

UK Dementia Research Institute, University of Cambridge

Verifisert e-postadresse på cam.ac.uk - Startside

Protein misfolding Neurodegeneration Virology Microbiology Immunology


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Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21) DL Mallery, WA McEwan, SR Bidgood, GJ Towers, CM Johnson, ... Proceedings of the National Academy of Sciences 107 (46), 19985-19990, 2010	472	2010
Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21 WA McEwan, JCH Tam, RE Watkinson, SR Bidgood, DL Mallery, ... Nature immunology 14 (4), 327-336, 2013	346	2013
A method for the acute and rapid degradation of endogenous proteins D Clift, WA McEwan, LI Labzin, V Konieczny, B Mogessie, LC James, ... Cell 171 (7), 1692-1706. e18, 2017	315	2017
Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly AJ Price, DA Jacques, WA McEwan, AJ Fletcher, S Essig, JW Chin, ... PLoS pathogens 10 (10), e1004459, 2014	240	2014
HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis DA Jacques, WA McEwan, L Hilditch, AJ Price, GJ Towers, LC James Nature 536 (7616), 349-353, 2016	205	2016
Intracellular sensing of complement C3 activates cell autonomous immunity JCH Tam, SR Bidgood, WA McEwan, LC James Science 345 (6201), 1256070, 2014	155	2014
IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis DL Mallery, CL Marquez, WA McEwan, CF Dickson, DA Jacques, ... Elife 7, e35335, 2018	133	2018
Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation WA McEwan, B Falcon, M Vaysburd, D Clift, AL Oblak, B Ghetti, ... Proceedings of the National Academy of Sciences 114 (3), 574-579, 2017	120	2017
Acute and rapid degradation of endogenous proteins by Trim-Away D Clift, C So, WA McEwan, LC James, M Schuh Nature Protocols 13 (10), 2149-2175, 2018	97	2018
AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization F Hauler, DL Mallery, WA McEwan, SR Bidgood, LC James Proceedings of the National Academy of Sciences 109 (48), 19733-19738, 2012	96	2012
Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species E Nachman, AS Wentink, K Madiona, L Bousset, T Katsinelos, K Allinson, ... Journal of Biological Chemistry 295 (28), 9676-9690, 2020	90	2020
TRIM21 promotes cGAS and RIG-I sensing of viral genomes during infection by antibody-opsonized virus RE Watkinson, WA McEwan, JCH Tam, M Vaysburd, LC James PLoS pathogens 11 (10), e1005253, 2015	82	2015
Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells SR Bidgood, JCH Tam, WA McEwan, DL Mallery, LC James Proceedings of the National Academy of Sciences 111 (37), 13463-13468, 2014	81	2014
Regulation of virus neutralization and the persistent fraction by TRIM21 WA McEwan, F Hauler, CR Williams, SR Bidgood, DL Mallery, ... Journal of virology 86 (16), 8482-8491, 2012	81	2012
Truncation of TRIM5 in the Feliformia explains the absence of retroviral restriction in cells of the domestic cat WA McEwan, T Schaller, LM Ylinen, MJ Hosie, GJ Towers, BJ Willett Journal of virology 83 (16), 8270-8275, 2009	70	2009
Measurement of tau filament fragmentation provides insights into prion-like spreading F Kundel, L Hong, B Falcon, WA McEwan, TCT Michaels, G Meisl, ... ACS chemical neuroscience 9 (6), 1276-1282, 2018	69	2018
Intracellular antibody‐mediated immunity and the role of TRIM21 WA McEwan, DL Mallery, DA Rhodes, J Trowsdale, LC James BioEssays, 2011	62	2011
The role of antibodies and their receptors in protection against ordered protein assembly in neurodegeneration T Katsinelos, BJ Tuck, AS Mukadam, WA McEwan Frontiers in Immunology 10, 1139, 2019	34	2019
Diverse HIV viruses are targeted by a conformationally dynamic antiviral MEC Caines, K Bichel, AJ Price, WA McEwan, GJ Towers, BJ Willett, ... Nature structural & molecular biology 19 (4), 411-416, 2012	33	2012
TRIM21-dependent intracellular antibody neutralization of virus infection WA McEwan, LC James Progress in molecular biology and translational science 129, 167-187, 2015	31	2015

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