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Wilbert Zwart
Wilbert Zwart
Professor Functional Genomics in Oncology, Groupleader, The Netherlands Cancer Institute
Verifisert e-postadresse på nki.nl - Startside
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Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150Glued and late endosome positioning
N Rocha, C Kuijl, R Van Der Kant, L Janssen, D Houben, H Janssen, ...
Journal of Cell Biology 185 (7), 1209-1225, 2009
7282009
Activation of endosomal dynein motors by stepwise assembly of Rab7–RILP–p150Glued, ORP1L, and the receptor βlll spectrin
M Johansson, N Rocha, W Zwart, I Jordens, L Janssen, C Kuijl, ...
The Journal of cell biology 176 (4), 459-471, 2007
5692007
A Pumilio-induced RNA structure switch in p27-3′ UTR controls miR-221 and miR-222 accessibility
M Kedde, M Van Kouwenhove, W Zwart, JAF Oude Vrielink, R Elkon, ...
Nature cell biology 12 (10), 1014-1020, 2010
4722010
Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9
G Korkmaz, R Lopes, AP Ugalde, E Nevedomskaya, R Han, K Myacheva, ...
Nature biotechnology 34 (2), 192-198, 2016
4372016
Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin
B Pang, X Qiao, L Janssen, A Velds, T Groothuis, R Kerkhoven, ...
Nature communications 4 (1), 1908, 2013
4182013
Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor
H Mohammed, C D’Santos, AA Serandour, HR Ali, GD Brown, A Atkins, ...
Cell reports 3 (2), 342-349, 2013
3882013
Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis
MD Wellenstein, SB Coffelt, DEM Duits, MH van Miltenburg, M Slagter, ...
Nature 572 (7770), 538-542, 2019
3582019
Genomic and phenotypic heterogeneity in prostate cancer
MC Haffner, W Zwart, MP Roudier, LD True, WG Nelson, JI Epstein, ...
Nature Reviews Urology 18 (2), 79-92, 2021
2562021
TRPM7 is required for breast tumor cell metastasis
J Middelbeek, AJ Kuipers, L Henneman, D Visser, I Eidhof, ...
Cancer research 72 (16), 4250-4261, 2012
2422012
The DNA methylation landscape of advanced prostate cancer
SG Zhao, WS Chen, H Li, A Foye, M Zhang, M Sjöström, R Aggarwal, ...
Nature genetics 52 (8), 778-789, 2020
2122020
Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis
CJ Desmet, T Gallenne, A Prieur, F Reyal, NL Visser, BS Wittner, MA Smit, ...
Proceedings of the National Academy of Sciences 110 (13), 5139-5144, 2013
1922013
Prostate cancer reactivates developmental epigenomic programs during metastatic progression
MM Pomerantz, X Qiu, Y Zhu, DY Takeda, W Pan, SC Baca, A Gusev, ...
Nature genetics 52 (8), 790-799, 2020
1722020
A diagnostic gene profile for molecular subtyping of breast cancer associated with treatment response
O Krijgsman, P Roepman, W Zwart, JS Carroll, S Tian, FA de Snoo, ...
Breast cancer research and treatment 133, 37-47, 2012
1652012
IL6/STAT3 signaling hijacks estrogen receptor α enhancers to drive breast cancer metastasis
R Siersbæk, V Scabia, S Nagarajan, I Chernukhin, EK Papachristou, ...
Cancer Cell 38 (3), 412-423. e9, 2020
1582020
Phosphatidylinositol 4-kinaseβ is critical for functional association of rab11 with the Golgi complex
P de Graaf, WT Zwart, RAJ van Dijken, M Deneka, TKF Schulz, N Geijsen, ...
Molecular biology of the cell 15 (4), 2038-2047, 2004
1522004
The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact
LF van Dessel, J van Riet, M Smits, Y Zhu, P Hamberg, ...
Nature communications 10 (1), 5251, 2019
1512019
Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape
W Zwart, A Griekspoor, C Kuijl, M Marsman, J van Rheenen, H Janssen, ...
Immunity 22 (2), 221-233, 2005
1512005
The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer
TE Hickey, LA Selth, KM Chia, G Laven-Law, HH Milioli, D Roden, ...
Nature medicine 27 (2), 310-320, 2021
1472021
PKA‐induced resistance to tamoxifen is associated with an altered orientation of ERα towards co‐activator SRC‐1
W Zwart, A Griekspoor, V Berno, K Lakeman, K Jalink, M Mancini, ...
The EMBO journal 26 (15), 3534-3544, 2007
1402007
Oestrogen receptor–co‐factor–chromatin specificity in the transcriptional regulation of breast cancer
W Zwart, V Theodorou, M Kok, S Canisius, S Linn, JS Carroll
The EMBO journal 30 (23), 4764-4776, 2011
1382011
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