| TREM2 is a receptor for β-amyloid that mediates microglial function Y Zhao, X Wu, X Li, LL Jiang, X Gui, Y Liu, Y Sun, B Zhu, JC Piña-Crespo, ... Neuron 97 (5), 1023-1031. e7, 2018 | 555 | 2018 |
| Elevated TREM2 gene dosage reprograms microglia responsivity and ameliorates pathological phenotypes in Alzheimer’s disease models CYD Lee, A Daggett, X Gu, LL Jiang, P Langfelder, X Li, N Wang, Y Zhao, ... Neuron 97 (5), 1032-1048. e5, 2018 | 309 | 2018 |
| Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72 Q Zhu, J Jiang, TF Gendron, M McAlonis-Downes, L Jiang, A Taylor, ... Nature neuroscience 23 (5), 615-624, 2020 | 182 | 2020 |
| ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity B Zhu, LL Jiang, T Huang, Y Zhao, T Liu, Y Zhong, X Li, A Campos, ... Nature Communications 8 (1), 1472, 2017 | 56 | 2017 |
| SORLA attenuates EphA4 signaling and amyloid β–induced neurodegeneration TY Huang, Y Zhao, L Jiang, X Li, Y Liu, Y Sun, JC Piña-Crespo, B Zhu, ... Journal of Experimental Medicine 214 (12), 3669-3685, 2017 | 44 | 2017 |
| Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE T Liu, B Zhu, Y Liu, X Zhang, J Yin, X Li, LL Jiang, AP Hodges, ... Journal of Experimental Medicine 217 (12), e20200474, 2020 | 41 | 2020 |
| Anticonvulsant effect of BmK IT2, a sodium channel‐specific neurotoxin, in rat models of epilepsy R Zhao, XY Zhang, J Yang, CC Weng, LL Jiang, JW Zhang, XQ Shu, YH Ji British journal of pharmacology 154 (5), 1116-1124, 2008 | 40 | 2008 |
| A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer’s disease P Zhao, Y Xu, LL Jiang, X Fan, L Li, X Li, H Arase, Y Zhao, W Cao, ... Science translational medicine 14 (661), eabq0095, 2022 | 39 | 2022 |
| Membralin deficiency dysregulates astrocytic glutamate homeostasis, leading to ALS-like impairment LL Jiang, B Zhu, Y Zhao, X Li, T Liu, J Pina-Crespo, L Zhou, W Xu, ... The Journal of Clinical Investigation 129 (8), 3103-3120, 2019 | 36 | 2019 |
| Arginine methyltransferase PRMT8 provides cellular stress tolerance in aging motoneurons Z Simandi, K Pajer, K Karolyi, T Sieler, LL Jiang, Z Kolostyak, Z Sari, ... Journal of Neuroscience 38 (35), 7683-7700, 2018 | 36 | 2018 |
| Intracellular trafficking of TREM2 is regulated by presenilin 1 Y Zhao, X Li, T Huang, L Jiang, Z Tan, M Zhang, IHJ Cheng, X Wang, ... Experimental & Molecular Medicine 49 (12), e405-e405, 2017 | 25 | 2017 |
| USP25 inhibition ameliorates Alzheimer’s pathology through the regulation of APP processing and Aβ generation Q Zheng, B Song, G Li, F Cai, M Wu, Y Zhao, LL Jiang, T Guo, M Shen, ... The Journal of Clinical Investigation 132 (5), 2022 | 24 | 2022 |
| GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer’s disease P Xu, JC Chang, X Zhou, W Wang, M Bamkole, E Wong, K Bettayeb, ... Journal of Experimental Medicine 218 (8), e20202446, 2021 | 22 | 2021 |
| Soluble SORLA enhances neurite outgrowth and regeneration through activation of the EGF Receptor/ERK signaling axis J Stupack, XP Xiong, LL Jiang, T Zhang, L Zhou, A Campos, B Ranscht, ... Journal of Neuroscience 40 (31), 5908-5921, 2020 | 21 | 2020 |
| LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions P Zhao, Y Xu, LL Jiang, X Fan, Z Ku, L Li, X Liu, M Deng, H Arase, JJ Zhu, ... Molecular neurodegeneration 17 (1), 44, 2022 | 13 | 2022 |
| Nitric oxide/peroxynitrite redox imbalance in endothelial cells measured with amperometric nanosensors A Burewicz, H Dawoud, LL Jiang, T Malinski American Journal of Analytical Chemistry 2013, 2013 | 13 | 2013 |
| GSAP regulates mitochondrial function through the Mitochondria-associated ER membrane in the pathogenesis of Alzheimer’s disease P Xu, JC Chang, X Zhou, W Wang, M Bamkole, E Wong, K Bettayeb, ... bioRxiv, 2020.11. 17.385245, 2020 | 1 | 2020 |
| The Pivotal Role of Nitric Oxide and Peroxynitrite Imbalance in Epileptic Seizures LL Jiang Ohio University, 2014 | 1 | 2014 |
| Aleglitazar, a Dual PPARa/? Agonist, Enhances Nitric Oxide Release and Reduces Nitroxidative Stress in Obese Zucker Rats: Comparison to Rosiglitazone and Fenofibrate RP Mason, RF Jacob, JJ Corbalan, LL Jiang, T Malinski Circulation 128 (suppl_22), A15154-A15154, 2013 | 1 | 2013 |
| BAC Transgenic Expression of Human TREM2-R47H Remodels Amyloid Plaques but Unable to Reprogram Plaque-associated Microglial Reactivity in 5xFAD Mice CYD Lee, AJ De La Rocha, K Inouye, P Langfelder, A Daggett, X Gu, ... bioRxiv, 2023.08. 03.551881, 2023 | | 2023 |
