Christopher Koth
Christopher Koth
Sr. Scientist, Genentech
Verifisert e-postadresse på gene.com - Startside
Sitert av
Sitert av
Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability
BEL Lauffer, R Mintzer, R Fong, S Mukund, C Tam, I Zilberleyb, B Flicke, ...
Journal of Biological Chemistry 288 (37), 26926-26943, 2013
Activation of Notch signaling pathway precedes heart regeneration in zebrafish
A Raya, CM Koth, D Büscher, Y Kawakami, T Itoh, RM Raya, G Sternik, ...
Proceedings of the National Academy of Sciences 100 (suppl_1), 11889-11895, 2003
Structural basis of Nav1. 7 inhibition by an isoform-selective small-molecule antagonist
S Ahuja, S Mukund, L Deng, K Khakh, E Chang, H Ho, S Shriver, C Young, ...
Science 350 (6267), aac5464, 2015
Crystal structure of the CorA Mg2+ transporter
VV Lunin, E Dobrovetsky, G Khutoreskaya, R Zhang, A Joachimiak, ...
Nature 440 (7085), 833-837, 2006
MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb
Y Kawakami, J Rodríguez-León, CM Koth, D Büscher, T Itoh, Á Raya, ...
Nature cell biology 5 (6), 513-519, 2003
The limb identity gene Tbx5 promotes limb initiation by interacting with Wnt2b and Fgf10
JK Ng, Y Kawakami, D Büscher, Á Raya, T Itoh, CM Koth, CR Esteban, ...
Oxford University Press for The Company of Biologists Limited 129 (22), 5161 …, 2002
Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism
E ter Haar, CM Koth, N Abdul-Manan, L Swenson, JT Coll, JA Lippke, ...
Structure 18 (9), 1083-1093, 2010
Structural and functional diversity calls for a new classification of ABC transporters
C Thomas, SG Aller, K Beis, EP Carpenter, G Chang, L Chen, E Dassa, ...
FEBS letters 594 (23), 3767-3775, 2020
Notch activity induces Nodal expression and mediates the establishment of left–right asymmetry in vertebrate embryos
A Raya, Y Kawakami, C Rodrıguez-Esteban, D Büscher, CM Koth, T Itoh, ...
Genes & development 17 (10), 1213-1218, 2003
Structural basis of Nav1. 7 inhibition by a gating-modifier spider toxin
H Xu, T Li, A Rohou, CP Arthur, F Tzakoniati, E Wong, A Estevez, C Kugel, ...
Cell 176 (4), 702-715. e14, 2019
Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases
MK Lemberg, J Menendez, A Misik, M Garcia, CM Koth, M Freeman
The EMBO journal 24 (3), 464-472, 2005
Structural basis for dual-mode inhibition of the ABC transporter MsbA
H Ho, A Miu, MK Alexander, NK Garcia, A Oh, I Zilberleyb, M Reichelt, ...
Nature 557 (7704), 196-201, 2018
Molecular basis for negative regulation of the glucagon receptor
CM Koth, JM Murray, S Mukund, A Madjidi, A Minn, HJ Clarke, T Wong, ...
Proceedings of the National Academy of Sciences 109 (36), 14393-14398, 2012
Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab
L Rougé, N Chiang, M Steffek, C Kugel, TI Croll, C Tam, A Estevez, ...
Science 367 (6483), 1224-1230, 2020
Potassium channels Kv1. 3 and KCa3. 1 cooperatively and compensatorily regulate antigen-specific memory T cell functions
EY Chiang, T Li, S Jeet, I Peng, J Zhang, WP Lee, J DeVoss, P Caplazi, ...
Nature communications 8 (1), 14644, 2017
A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells
AH Nile, F de Sousa e Melo, S Mukund, R Piskol, S Hansen, L Zhou, ...
Nature chemical biology 14 (6), 582-590, 2018
High-throughput production of prokaryotic membrane proteins
E Dobrovetsky, ML Lu, R Andorn-Broza, G Khutoreskaya, JE Bray, ...
Journal of Structural and Functional Genomics 6, 33-50, 2005
A novel inhibitor of the LolCDE ABC transporter essential for lipoprotein trafficking in Gram-negative bacteria
NN Nickerson, CC Jao, Y Xu, J Quinn, E Skippington, MK Alexander, ...
Antimicrobial Agents and Chemotherapy 62 (4), 10.1128/aac. 02151-17, 2018
Disrupting gram-negative bacterial outer membrane biosynthesis through inhibition of the lipopolysaccharide transporter MsbA
MK Alexander, A Miu, A Oh, M Reichelt, H Ho, C Chalouni, S Labadie, ...
Antimicrobial Agents and Chemotherapy 62 (11), 10.1128/aac. 01142-18, 2018
Refolding and characterization of a soluble ectodomain complex of the calcitonin gene-related peptide receptor
CM Koth, N Abdul-Manan, CA Lepre, PJ Connolly, S Yoo, AK Mohanty, ...
Biochemistry 49 (9), 1862-1872, 2010
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