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Colin Adrain
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Executioner caspase-3,-6, and-7 perform distinct, non-redundant roles during the demolition phase of apoptosis
EA Slee, C Adrain, SJ Martin
Journal of biological Chemistry 276 (10), 7320-7326, 2001
15322001
The mitochondrial apoptosome: a killer unleashed by the cytochrome seas
C Adrain, SJ Martin
Trends in biochemical sciences 26 (6), 390-397, 2001
8402001
Serial killers: ordering caspase activation events in apoptosis
EA Slee, C Adrain, SJ Martin
Cell Death & Differentiation 6 (11), 1067-1074, 1999
6571999
Apoptosis‐associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl‐2
C Adrain, EM Creagh, SJ Martin
The EMBO journal, 2001
6222001
Analysis of the composition, assembly kinetics and activity of native Apaf‐1 apoptosomes
MM Hill, C Adrain, PJ Duriez, EM Creagh, SJ Martin
The EMBO journal 23 (10), 2134-2145, 2004
5042004
Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE
C Adrain, M Zettl, Y Christova, N Taylor, M Freeman
Science 335 (6065), 225, 2012
4672012
Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics
P Delivani, C Adrain, RC Taylor, PJ Duriez, SJ Martin
Molecular cell 21 (6), 761-773, 2006
2382006
Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B
C Adrain, BM Murphy, SJ Martin
Journal of Biological Chemistry 280 (6), 4663-4673, 2005
2342005
Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling
M Zettl, C Adrain, K Strisovsky, V Lastun, M Freeman
Cell 145 (1), 79-91, 2011
1802011
New lives for old: evolution of pseudoenzyme function illustrated by iRhoms
C Adrain, M Freeman
Nature reviews Molecular cell biology 13 (8), 489-498, 2012
1792012
Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region
C Adrain, EA Slee, MT Harte, SJ Martin
Journal of Biological Chemistry 274 (30), 20855-20860, 1999
1701999
Portrait of a killer: the mitochondrial apoptosome emerges from the shadows
MM Hill, C Adrain, SJ Martin
Molecular interventions 3 (1), 19, 2003
1662003
Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex
D Twiddy, DG Brown, C Adrain, R Jukes, SJ Martin, GM Cohen, ...
Journal of Biological Chemistry 279 (19), 19665-19682, 2004
1572004
Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation
Y Christova, C Adrain, P Bambrough, A Ibrahim, M Freeman
EMBO reports 14 (10), 884-890, 2013
1552013
The Apoptosome Pathway to Caspase Activation in Primary Human Neutrophils Exhibits Dramatically Reduced Requirements for Cytochrome c
BM Murphy, AJ O'Neill, C Adrain, RWG Watson, SJ Martin
The Journal of experimental medicine 197 (5), 625-632, 2003
1512003
Human and murine granzyme B exhibit divergent substrate preferences
SP Cullen, C Adrain, AU Lüthi, PJ Duriez, SJ Martin
The Journal of cell biology 176 (4), 435-444, 2007
1482007
CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-κB activation pathways
L Bouchier-Hayes, H Conroy, H Egan, C Adrain, EM Creagh, ...
Journal of Biological Chemistry 276 (47), 44069-44077, 2001
1352001
Mammalian EGF receptor activation by the rhomboid protease RHBDL2
C Adrain, K Strisovsky, M Zettl, L Hu, MK Lemberg, M Freeman
EMBO reports 12 (5), 421-427, 2011
1312011
The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics
C Adrain, PJ Duriez, G Brumatti, P Delivani, SJ Martin
Journal of Biological Chemistry 281 (12), 8118-8125, 2006
1102006
Phosphorylation of iRhom2 controls stimulated proteolytic shedding by the metalloprotease ADAM17/TACE
M Cavadas, I Oikonomidi, CJ Gaspar, E Burbridge, M Badenes, I Félix, ...
Cell reports 21 (3), 745-757, 2017
1082017
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