Alexander Hoffmann
Alexander Hoffmann
Thomas Asher Professor of Microbiology, Institute for Quantitative and Computational Biosciences
Verified email at - Homepage
Cited by
Cited by
The IκB-NF-κB signaling module: temporal control and selective gene activation
A Hoffmann, A Levchenko, ML Scott, D Baltimore
Science 298 (5596), 1241-1245, 2002
Circuitry of nuclear factor κB signaling
A Hoffmann, D Baltimore
Immunological reviews 210 (1), 171-186, 2006
Molecular determinants of crosstalk between nuclear receptors and toll-like receptors
S Ogawa, J Lozach, C Benner, G Pascual, RK Tangirala, S Westin, ...
Cell 122 (5), 707-721, 2005
Transcriptional regulation via the NF-κ B signaling module
A Hoffmann, G Natoli, G Ghosh
Oncogene 25 (51), 6706-6716, 2006
Stimulus specificity of gene expression programs determined by temporal control of IKK activity
SL Werner, D Barken, A Hoffmann
Science 309 (5742), 1857-1861, 2005
A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling
VR Ramirez-Carrozzi, D Braas, DM Bhatt, CS Cheng, C Hong, KR Doty, ...
Cell 138 (1), 114-128, 2009
Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis
N Takeda, EL O'Dea, A Doedens, J Kim, A Weidemann, C Stockmann, ...
Genes & development 24 (5), 491-501, 2010
One nucleotide in a κB site can determine cofactor specificity for NF-κB dimers
TH Leung, A Hoffmann, D Baltimore
Cell 118 (4), 453-464, 2004
Crystal structure of TFIID TATA-box binding protein
DB Nikolov, SH Hu, J Lin, A Gasch, A Hoffmann, M Horikoshi, NH Chua, ...
Nature 360 (6399), 40-46, 1992
Genetic analysis of NF‐κB/Rel transcription factors defines functional specificities
A Hoffmann, TH Leung, D Baltimore
The EMBO journal 22 (20), 5530-5539, 2003
A fourth IκB protein within the NF-κB signaling module
S Basak, H Kim, JD Kearns, V Tergaonkar, E O'Dea, SL Werner, ...
Cell 128 (2), 369-381, 2007
CK2 is a C-terminal IκB kinase responsible for NF-κB activation during the UV response
T Kato Jr, M Delhase, A Hoffmann, M Karin
Molecular cell 12 (4), 829-839, 2003
A single NFκB system for both canonical and non-canonical signaling
VFS Shih, R Tsui, A Caldwell, A Hoffmann
Cell research 21 (1), 86-102, 2011
Purification of his-tagged proteins in non-denaturing conditions suggests a convenient method for protein interaction studies.
A Hoffmann, RG Roeder
Nucleic Acids Research 19 (22), 6337, 1991
Crystal structure of a human TATA box-binding protein/TATA element complex
SKB DB Nikolov, H Chen, ED Halay, A Hoffmann, RG Roeder
Proc. Natl. Acad. Sci. USA 93, 4862-4867, 1996
Highly conserved core domain and unique N terminus with presumptive regulatory motifs in a human TATA factor (TFIID)
A Hoffmann, E Sinn, T Yamamoto, J Wang, A Roy, M Horikoshi, ...
Nature 346 (6282), 387-390, 1990
Signaling via the NFκB system
S Mitchell, J Vargas, A Hoffmann
Wiley Interdisciplinary Reviews: Systems Biology and Medicine 8 (3), 227-241, 2016
Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages
S Sanjabi, A Hoffmann, HC Liou, D Baltimore, ST Smale
Proceedings of the National Academy of Sciences 97 (23), 12705-12710, 2000
Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis—CREB and NF-κB as key regulators
JM Park, FR Greten, A Wong, RJ Westrick, JSC Arthur, K Otsu, ...
Immunity 23 (3), 319-329, 2005
Structural similarity between TAFs and the heterotetrameric core of the histone octamer
X Xie, T Kokubo, SL Cohen, UA Mirza, A Hoffmann, BT Chait, RG Roeder, ...
Nature 380 (6572), 316-322, 1996
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