David Owen
David Owen
MRC Clinician Scientist - Imperial College London
Adresse e-mail validée de imperial.ac.uk - Page d'accueil
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An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28
DR Owen, AJ Yeo, RN Gunn, K Song, G Wadsworth, A Lewis, C Rhodes, ...
Journal of Cerebral Blood Flow & Metabolism 32 (1), 1-5, 2012
4782012
Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [11C]PBR28 PET Brain Imaging Study
PS Bloomfield, S Selvaraj, M Veronese, G Rizzo, A Bertoldo, DR Owen, ...
American Journal of Psychiatry 173 (1), 44-52, 2016
2922016
Mixed-affinity binding in humans with 18-kDa translocator protein ligands
DRJ Owen, RN Gunn, EA Rabiner, I Bennacef, M Fujita, WC Kreisl, ...
Journal of nuclear medicine 52 (1), 24-32, 2011
2872011
Roles of microglia in brain development, tissue maintenance and repair
MA Michell-Robinson, H Touil, LM Healy, DR Owen, BA Durafourt, ...
Brain 138 (5), 1138-1159, 2015
2342015
Imaging intraplaque inflammation in carotid atherosclerosis with 11C-PK11195 positron emission tomography/computed tomography
O Gaemperli, J Shalhoub, DRJ Owen, F Lamare, S Johansson, N Fouladi, ...
European heart journal 33 (15), 1902-1910, 2012
2202012
Two Binding Sites for [3H]PBR28 in Human Brain: Implications for TSPO PET Imaging of Neuroinflammation
DR Owen, OW Howell, SP Tang, LA Wells, I Bennacef, M Bergstrom, ...
Journal of Cerebral Blood Flow & Metabolism 30 (9), 1608-1618, 2010
1812010
Imaging of atherosclerosis
DRJ Owen, AC Lindsay, RP Choudhury, ZA Fayad
Annual review of medicine 62, 25-40, 2011
1212011
Inflammation within carotid atherosclerotic plaque: assessment with late-phase contrast-enhanced US
DR Owen, J Shalhoub, S Miller, T Gauthier, O Doryforou, AH Davies, ...
Radiology 255 (2), 638-644, 2010
1052010
Determination of [11C]PBR28 Binding Potential in vivo: A First Human TSPO Blocking Study
DR Owen, Q Guo, NJ Kalk, A Colasanti, D Kalogiannopoulou, R Dimber, ...
Journal of Cerebral Blood Flow & Metabolism 34 (6), 989-994, 2014
1012014
The use of contrast enhanced ultrasound in carotid arterial disease
J Shalhoub, DRJ Owen, T Gauthier, C Monaco, ELS Leen, AH Davies
European journal of vascular and endovascular surgery 39 (4), 381-387, 2010
902010
Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans
DR Owen, N Narayan, L Wells, L Healy, E Smyth, EA Rabiner, ...
Journal of Cerebral Blood Flow & Metabolism 37 (8), 2679-2690, 2017
792017
Quantification of the specific translocator protein signal of 18F-PBR111 in healthy humans: a genetic polymorphism effect on in vivo binding
Q Guo, A Colasanti, DR Owen, M Onega, A Kamalakaran, I Bennacef, ...
Journal of nuclear medicine 54 (11), 1915-1923, 2013
772013
Identifying improved TSPO PET imaging probes through biomathematics: the impact of multiple TSPO binding sites in vivo
Q Guo, DR Owen, EA Rabiner, FE Turkheimer, RN Gunn
Neuroimage 60 (2), 902-910, 2012
752012
In vivo assessment of brain white matter inflammation in multiple sclerosis with 18F-PBR111 PET
A Colasanti, Q Guo, N Muhlert, P Giannetti, M Onega, RD Newbould, ...
Journal of Nuclear Medicine 55 (7), 1112-1118, 2014
742014
Imaging brain microglial activation using positron emission tomography and translocator protein-specific radioligands
DRJ Owen, PM Matthews
International review of neurobiology 101, 19-39, 2011
712011
Hippocampal neuroinflammation, functional connectivity, and depressive symptoms in multiple sclerosis
A Colasanti, Q Guo, P Giannetti, MB Wall, RD Newbould, C Bishop, ...
Biological psychiatry 80 (1), 62-72, 2016
702016
Decaffeinated coffee and glucose metabolism in young men
JA Greenberg, DR Owen, A Geliebter
Diabetes care 33 (2), 278-280, 2010
662010
Classical diseases revisited: transient global amnesia
D Owen, B Paranandi, R Sivakumar, M Seevaratnam
Postgraduate medical journal 83 (978), 236-239, 2007
652007
Minocycline reduces chronic microglial activation after brain trauma but increases neurodegeneration
G Scott, H Zetterberg, A Jolly, JH Cole, S De Simoni, PO Jenkins, ...
Brain 141 (2), 459-471, 2018
562018
Direct and indirect effects of immune and central nervous system–resident cells on human oligodendrocyte progenitor cell differentiation
CS Moore, QL Cui, NM Warsi, BA Durafourt, N Zorko, DR Owen, JP Antel, ...
The Journal of Immunology 194 (2), 761-772, 2015
552015
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