Scott A. Summers
Scott A. Summers
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Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
AD Kohn, SA Summers, MJ Birnbaum, RA Roth
Journal of Biological Chemistry 271 (49), 31372-31378, 1996
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
WL Holland, JT Brozinick, LP Wang, ED Hawkins, KM Sargent, Y Liu, ...
Cell metabolism 5 (3), 167-179, 2007
Ceramides in insulin resistance and lipotoxicity
SA Summers
Progress in lipid research 45 (1), 42-72, 2006
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
WL Holland, RA Miller, ZV Wang, K Sun, BM Barth, HH Bui, KE Davis, ...
Nature medicine 17 (1), 55-63, 2011
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice
WL Holland, BT Bikman, LP Wang, G Yuguang, KM Sargent, S Bulchand, ...
The Journal of clinical investigation 121 (5), 1858-1870, 2011
A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids
JA Chavez, TA Knotts, LP Wang, G Li, RT Dobrowsky, GL Florant, ...
Journal of Biological Chemistry 278 (12), 10297-10303, 2003
A ceramide-centric view of insulin resistance
JA Chavez, SA Summers
Cell metabolism 15 (5), 585-594, 2012
Ceramides–lipotoxic inducers of metabolic disorders
B Chaurasia, SA Summers
Trends in Endocrinology & Metabolism 26 (10), 538-550, 2015
Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights from in Vivo Manipulation of Sphingolipid Metabolism
WL Holland, SA Summers
Endocrine reviews 29 (4), 381-402, 2008
Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes
JA Chavez, SA Summers
Archives of biochemistry and biophysics 419 (2), 101-109, 2003
Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide
SA Summers, LA Garza, H Zhou, MJ Birnbaum
Molecular and cellular biology 18 (9), 5457-5464, 1998
Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B
S Stratford, KL Hoehn, F Liu, SA Summers
Journal of Biological Chemistry 279 (35), 36608-36615, 2004
CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance
S Raichur, ST Wang, PW Chan, Y Li, J Ching, B Chaurasia, S Dogra, ...
Cell metabolism 20 (4), 687-695, 2014
Ceramides as modulators of cellular and whole-body metabolism
BT Bikman, SA Summers
The Journal of clinical investigation 121 (11), 4222-4230, 2011
Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis
H Zhou, SA Summers, MJ Birnbaum, RN Pittman
Journal of Biological Chemistry 273 (26), 16568-16575, 1998
Construction and characterization of a conditionally active version of the serine/threonine kinase Akt
AD Kohn, A Barthel, KS Kovacina, A Boge, B Wallach, SA Summers, ...
Journal of Biological Chemistry 273 (19), 11937-11943, 1998
Lipid mediators of insulin resistance
WL Holland, TA Knotts, JA Chavez, LP Wang, KL Hoehn, SA Summers
Nutrition reviews 65 (suppl_1), S39-S46, 2007
Sphingolipids and phospholipids in insulin resistance and related metabolic disorders
PJ Meikle, SA Summers
Nature Reviews Endocrinology 13 (2), 79-91, 2017
Caffeine stimulates hepatic lipid metabolism by the autophagy‐lysosomal pathway in mice
RA Sinha, BL Farah, BK Singh, MM Siddique, Y Li, Y Wu, OR Ilkayeva, ...
Hepatology 59 (4), 1366-1380, 2014
Targeting a ceramide double bond improves insulin resistance and hepatic steatosis
B Chaurasia, TS Tippetts, R Mayoral Monibas, J Liu, Y Li, L Wang, ...
Science 365 (6451), 386-392, 2019
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