| Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase T Paquet, C Le Manach, DG Cabrera, Y Younis, PP Henrich, TS Abraham, ... Science translational medicine 9 (387), eaad9735, 2017 | 259 | 2017 |
| Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards … J Reader, M Botha, A Theron, SB Lauterbach, C Rossouw, D Engelbrecht, ... Malaria journal 14, 1-17, 2015 | 132 | 2015 |
| Discovery of novel alkylated (bis) urea and (bis) thiourea polyamine analogues with potent antimalarial activities BK Verlinden, J Niemand, J Snyman, SK Sharma, RJ Beattie, PM Woster, ... Journal of medicinal chemistry 54 (19), 6624-6633, 2011 | 124 | 2011 |
| Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities LM Birkholtz, M Williams, J Niemand, AI Louw, L Persson, O Heby Biochemical Journal 438 (2), 229-244, 2011 | 116 | 2011 |
| Heterologous expression of plasmodial proteins for structural studies and functional annotation LM Birkholtz, G Blatch, TL Coetzer, HC Hoppe, E Human, EJ Morris, ... Malaria journal 7, 1-20, 2008 | 115 | 2008 |
| Co-inhibition of Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase reveals perturbation-specific compensatory mechanisms by transcriptome … AC van Brummelen, KL Olszewski, D Wilinski, M Llinas, AI Louw, ... Journal of Biological Chemistry 284 (7), 4635-4646, 2009 | 109 | 2009 |
| Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation R Van Biljon, R Van Wyk, HJ Painter, L Orchard, J Reader, J Niemand, ... BMC genomics 20, 1-16, 2019 | 87 | 2019 |
| Quantitative chromatin proteomics reveals a dynamic histone post-translational modification landscape that defines asexual and sexual Plasmodium falciparum parasites N Coetzee, S Sidoli, R Van Biljon, H Painter, M Llinás, BA Garcia, ... Scientific reports 7 (1), 607, 2017 | 87 | 2017 |
| Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box J Reader, ME van der Watt, D Taylor, C Le Manach, N Mittal, S Ottilie, ... Nature communications 12 (1), 269, 2021 | 79 | 2021 |
| Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites N Coetzee, H von Grüning, D Opperman, M van der Watt, J Reader, ... Scientific reports 10 (1), 2355, 2020 | 68 | 2020 |
| UCT943, a next-generation Plasmodium falciparum PI4K inhibitor preclinical candidate for the treatment of malaria C Brunschwig, N Lawrence, D Taylor, E Abay, M Njoroge, GS Basarab, ... Antimicrobial agents and chemotherapy 62 (9), 10.1128/aac. 00012-18, 2018 | 68 | 2018 |
| Discovering new transmission-blocking antimalarial compounds: challenges and opportunities LM Birkholtz, TL Coetzer, D Mancama, D Leroy, P Alano Trends in parasitology 32 (9), 669-681, 2016 | 63 | 2016 |
| Synthesis and in vitro biological evaluation of dihydroartemisinyl-chalcone esters FJ Smit, RA van Biljon, LM Birkholtz, DND David European journal of medicinal chemistry 90, 33-44, 2015 | 60 | 2015 |
| Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in … K Singh, J Okombo, C Brunschwig, F Ndubi, L Barnard, C Wilkinson, ... Journal of medicinal chemistry 60 (4), 1432-1448, 2017 | 56 | 2017 |
| Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain … LM Birkholtz, C Wrenger, F Joubert, GA Wells, RD Walter, AI Louw Biochemical Journal 377 (2), 439-448, 2004 | 56 | 2004 |
| Identification of a potential antimalarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across the parasite life cycle C Le Manach, AT Nchinda, T Paquet, D Gonzàlez Cabrera, Y Younis, ... Journal of medicinal chemistry 59 (21), 9890-9905, 2016 | 52 | 2016 |
| Transmission-blocking drugs for malaria elimination LM Birkholtz, P Alano, D Leroy Trends in parasitology 38 (5), 390-403, 2022 | 50 | 2022 |
| Bioassay-guided isolation and identification of gametocytocidal compounds from Artemisia afra (Asteraceae) P Moyo, P Kunyane, MA Selepe, JN Eloff, J Niemand, AI Louw, ... Malaria journal 18, 1-11, 2019 | 48 | 2019 |
| Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels JVW Becker, L Mtwisha, BG Crampton, S Stoychev, AC van Brummelen, ... BMC genomics 11, 1-16, 2010 | 47 | 2010 |
| Resisting resistance: is there a solution for malaria? BK Verlinden, A Louw, LM Birkholtz Expert opinion on drug discovery 11 (4), 395-406, 2016 | 46 | 2016 |
Braam LouwProfessor of Biochemistry, University of PretoriaVerified email at up.ac.za
