| ecDNA hubs drive cooperative intermolecular oncogene expression KL Hung, KE Yost, L Xie, Q Shi, K Helmsauer, J Luebeck, R Schöpflin, ... Nature 600 (7890), 731-736, 2021 | 142 | 2021 |
| AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications J Luebeck, C Coruh, SR Dehkordi, JT Lange, KM Turner, V Deshpande, ... Nature communications 11 (1), 4374, 2020 | 60 | 2020 |
| The evolutionary dynamics of extrachromosomal DNA in human cancers JT Lange, JC Rose, CY Chen, Y Pichugin, L Xie, J Tang, KL Hung, ... Nature genetics 54 (10), 1527-1533, 2022 | 55 | 2022 |
| Genomic characterization of patient-derived xenograft models established from fine needle aspirate biopsies of a primary pancreatic ductal adenocarcinoma and from patient … RJ Allaway, DA Fischer, FB De Abreu, TB Gardner, SR Gordon, RJ Barth, ... Oncotarget 7 (13), 17087, 2016 | 48 | 2016 |
| Principles of ecDNA random inheritance drive rapid genome change and therapy resistance in human cancers JT Lange, CY Chen, Y Pichugin, L Xie, J Tang, KL Hung, KE Yost, Q Shi, ... BioRxiv, 2021.06. 11.447968, 2021 | 16 | 2021 |
| The landscape of extrachromosomal circular DNA in medulloblastoma OS Chapman, J Luebeck, S Wani, A Tiwari, M Pagadala, S Wang, ... bioRxiv, 2021.10. 18.464907, 2021 | 10 | 2021 |
| Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma OS Chapman, J Luebeck, S Sridhar, ITL Wong, D Dixit, S Wang, G Prasad, ... Nature genetics 55 (12), 2189-2199, 2023 | 2 | 2023 |
| Tumors driven by oncogene amplified extrachromosomal DNA (ecDNA) demonstrate enhanced sensitivity to cell cycle checkpoint kinase 1 (CHK1) inhibition S Chowdhry, S Milutinovic, E Tse, S Garcia, D Perusse, M Ritland, J Ko, ... Cancer Research 83 (7_Supplement), 1626-1626, 2023 | 2 | 2023 |
| Oral CHK1 inhibitor BBI-355 allows flexibility of dose and schedule with demonstration of monotherapy and combinational antitumor activity in extrachromosomal DNA (ecDNA … RJ Hansen, A Steffy, J Plum, A Ardeshiri, E Tse, S Garcia, B Norman, ... Cancer Research 84 (6_Supplement), 613-613, 2024 | | 2024 |
| A novel, potent and selective ribonucleotide reductase (RNR) inhibitor, BBI-825, blocks extrachromosomal DNA (ecDNA) amplification-mediated resistance to KRAS G12C inhibitor in … S Chowdhry, R Hansen, J Mauger, AM Pferdekamper, E Tse, B Norman, ... MOLECULAR CANCER THERAPEUTICS 22 (12), 2023 | | 2023 |
| Coordinated inheritance of extrachromosomal DNA species in human cancer cells KL Hung, MG Jones, ITL Wong, JT Lange, J Luebeck, E Scanu, BJ He, ... bioRxiv, 2023 | | 2023 |
| Abstract B082: A novel, potent and selective ribonucleotide reductase (RNR) inhibitor, BBI-825, blocks extrachromosomal DNA (ecDNA) amplification-mediated resistance to … S Chowdhry, R Hansen, J Mauger, AM Pferdekamper, E Tse, B Norman, ... NaN, B082-B082, 2023 | | 2023 |
| Deciphering the evolutionary dynamics of extrachromosomal DNA in human cancer JT Lange, PS Mischel NATURE GENETICS 54 (10), 1455-1455, 2022 | | 2022 |
| The evolutionary dynamics of extrachromosomal DNA in human cancers JT Lange, JC Rose, CY Chen, Y Pichugin, L Xie, J Tang, KL Hung, ... Nature Genetics, 1-7, 2022 | | 2022 |
| Cancer Being Extra: Extrachromosomal DNA Promotes Heterogeneity and Resistance in Cancer JT Lange University of California, San Diego, 2022 | | 2022 |
| Entwicklung des Missbrauchs psychotroper Pflanzen und Pilze in Deutschland–Interpretation der Zahlen aus 3 Giftinformationszentren für die Jahre 2007–2013 J Pietsch, K Scheffel, D Acquarone, I Koch, M Deters, ... Das Gesundheitswesen 43 (06), 532-539, 2018 | | 2018 |
