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Salvatore La Rosa
Salvatore La Rosa
Children's Tumor Foundation
Verifisert e-postadresse på ctf.org
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SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist
SN Haydar, C Ghiron, L Bettinetti, H Bothmann, TA Comery, J Dunlop, ...
Bioorganic & medicinal chemistry 17 (14), 5247-5258, 2009
652009
Creating a data resource: what will it take to build a medical information commons?
PA Deverka, MA Majumder, AG Villanueva, M Anderson, AC Bakker, ...
Genome Medicine 9 (1), 1-5, 2017
432017
The synthesis of 7-deazaguanines as potential inhibitors of guanosine triphosphate cyclohydrolase I
CL Gibson, S La Rosa, K Ohta, PH Boyle, F Leurquin, A Lemaçon, ...
Tetrahedron 60 (4), 943-959, 2004
432004
Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1 …
C Ghiron, SN Haydar, S Aschmies, H Bothmann, C Castaldo, ...
Journal of medicinal chemistry 53 (11), 4379-4389, 2010
362010
Cutaneous neurofibromas in the genomics era: current understanding and open questions
RJ Allaway, SJC Gosline, S La Rosa, P Knight, A Bakker, J Guinney, ...
British journal of cancer 118 (12), 1539-1548, 2018
352018
A prototype solid phase synthesis of pteridines and related heterocyclic compounds
CL Gibson, S La Rosa, CJ Suckling
Organic & biomolecular chemistry 1 (11), 1909-1918, 2003
312003
A traceless solid-phase synthesis of pteridines
CL Gibson, S La Rosa, CJ Suckling
Tetrahedron letters 44 (6), 1267-1270, 2003
262003
A high-throughput molecular data resource for cutaneous neurofibromas
SJC Gosline, H Weinberg, P Knight, T Yu, X Guo, N Prasad, A Jones, ...
Scientific data 4 (1), 1-9, 2017
212017
Traditional and systems biology based drug discovery for the rare tumor syndrome neurofibromatosis type 2
Synodos for NF2 Consortium, R Allaway, SP Angus, RL Beauchamp, ...
PloS one 13 (6), e0197350, 2018
142018
Neurofibromatosis as a gateway to better treatment for a variety of malignancies
AC Bakker, S La Rosa, LS Sherman, P Knight, H Lee, P Pancza, M Nievo
Progress in neurobiology 152, 149-165, 2017
142017
Novel hits in the correction of ΔF508-cystic fibrosis transmembrane conductance regulator (CFTR) protein: synthesis, pharmacological, and ADME evaluation of tetrahydropyrido [4 …
E Pesci, L Bettinetti, P Fanti, LJV Galietta, S La Rosa, L Magnoni, ...
Journal of Medicinal Chemistry 58 (24), 9697-9711, 2015
122015
Drug discovery and development for Huntington’s disease-an orphan indication with high medical need
F Heitz, S La Rosa, E Gonzalez-Couto, G Gaviraghi, GC Terstappen
IDrugs 11 (9), 653-660, 2008
112008
Recombinant Adeno Associated Viral (AAV) vector type 9 delivery of Ex1-Q138-mutant huntingtin in the rat striatum as a short-time model for in vivo studies in drug discovery
I Ceccarelli, P Fiengo, R Remelli, V Miragliotta, L Rossini, I Biotti, ...
Neurobiology of disease 86, 41-51, 2016
102016
A phenotypic screening assay for modulators of Huntingtin-induced transcriptional dysregulation
G Lazzeroni, T Benicchi, F Heitz, L Magnoni, D Diamanti, L Rossini, ...
Journal of Biomolecular Screening 18 (9), 984-996, 2013
92013
Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK
LS Chang, JL Oblinger, AE Smith, M Ferrer, SP Angus, E Hawley, ...
Plos one 16 (7), e0252048, 2021
72021
Probing the chemical–biological relationship space with the Drug Target Explorer
RJ Allaway, S La Rosa, J Guinney, SJC Gosline
Journal of Cheminformatics 10 (1), 1-14, 2018
72018
Engaging a community to enable disease-centric data sharing with the NF Data Portal
RJ Allaway, S La Rosa, S Verma, L Mangravite, J Guinney, J Blakeley, ...
Scientific data 6 (1), 1-4, 2019
62019
Synthesis of 3‐imidazolylazole derivatives from a new nitrile oxide
F Foti, G Grassi, F Risitano, S La Rosa
Journal of Heterocyclic Chemistry 38 (2), 539-540, 2001
62001
Fused 3-hydroxy-3-trifluoromethylpyrazoles inhibit mutant huntingtin toxicity
S La Rosa, T Benicchi, L Bettinetti, I Ceccarelli, E Diodato, C Federico, ...
ACS medicinal chemistry letters 4 (10), 979-984, 2013
52013
Synthesis of 7-substituted-(2, 3-dihydro-1, 4-benzodioxin-5-yl)-piperazine
F Rancati, SM Bromidge, S Del Sordo, S La Rosa, C Parini, S Gagliardi
Synthetic Communications® 38 (15), 2507-2520, 2008
42008
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Artikler 1–20