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Robert Prins
Robert Prins
Verifisert e-postadresse på mednet.ucla.edu
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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
L Dang, DW White, S Gross, BD Bennett, MA Bittinger, EM Driggers, ...
Nature 462 (7274), 739-744, 2009
40862009
Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma
TF Cloughesy, AY Mochizuki, JR Orpilla, W Hugo, AH Lee, TB Davidson, ...
Nature medicine 25 (3), 477-486, 2019
8012019
Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic cytotoxicity and intracranial T-cell infiltration
JS Yu, CJ Wheeler, PM Zeltzer, H Ying, DN Finger, PK Lee, WH Yong, ...
Cancer research 61 (3), 842-847, 2001
6582001
Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment
LM Liau, RM Prins, SM Kiertscher, SK Odesa, TJ Kremen, AJ Giovannone, ...
Clinical Cancer Research 11 (15), 5515-5525, 2005
5752005
Immunotherapy response assessment in neuro-oncology: a report of the RANO working group
H Okada, M Weller, R Huang, G Finocchiaro, MR Gilbert, W Wick, ...
The Lancet Oncology 16 (15), e534-e542, 2015
5482015
Gene Expression Profile Correlates with T-Cell Infiltration and Relative Survival in Glioblastoma Patients Vaccinated with Dendritic Cell ImmunotherapyDendritic Cell …
RM Prins, H Soto, V Konkankit, SK Odesa, A Eskin, WH Yong, SF Nelson, ...
Clinical cancer research 17 (6), 1603-1615, 2011
4582011
First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma
LM Liau, K Ashkan, DD Tran, JL Campian, JE Trusheim, CS Cobbs, ...
Journal of translational medicine 16 (1), 1-9, 2018
3962018
An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent PathwayEGFR Signaling Regulates Cholesterol Metabolism
D Guo, F Reinitz, M Youssef, C Hong, D Nathanson, D Akhavan, D Kuga, ...
Cancer discovery 1 (5), 442-456, 2011
3932011
Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy
WB Pope, RM Prins, M Albert Thomas, R Nagarajan, KE Yen, MA Bittinger, ...
Journal of neuro-oncology 107, 197-205, 2012
3312012
EGFR signaling through an Akt-SREBP-1–dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy
D Guo, RM Prins, J Dang, D Kuga, A Iwanami, H Soto, KY Lin, TT Huang, ...
Science signaling 2 (101), ra82-ra82, 2009
3242009
Treatment of intracranial gliomas with bone marrow—derived dendritic cells pulsed with tumor antigens
LM Liau, KL Black, RM Prins, SN Sykes, PL DiPatre, TF Cloughesy, ...
Journal of neurosurgery 90 (6), 1115-1124, 1999
3191999
The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis
D Guo, IJ Hildebrandt, RM Prins, H Soto, MM Mazzotta, J Dang, J Czernin, ...
Proceedings of the National Academy of Sciences 106 (31), 12932-12937, 2009
2462009
2-Hydroxyglutarate inhibits ATP synthase and mTOR signaling
X Fu, RM Chin, L Vergnes, H Hwang, G Deng, Y Xing, MY Pai, S Li, L Ta, ...
Cell metabolism 22 (3), 508-515, 2015
2062015
The TLR-7 agonist, imiquimod, enhances dendritic cell survival and promotes tumor antigen-specific T cell priming: relation to central nervous system antitumor immunity
RM Prins, N Craft, KW Bruhn, H Khan-Farooqi, RC Koya, R Stripecke, ...
The Journal of Immunology 176 (1), 157-164, 2006
2052006
An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicitySREBP1 signaling protects from lipotoxicity
KJ Williams, JP Argus, Y Zhu, MQ Wilks, BN Marbois, AG York, Y Kidani, ...
Cancer research 73 (9), 2850-2862, 2013
1652013
Cytomegalovirus immunity after vaccination with autologous glioblastoma lysate
RM Prins, TF Cloughesy, LM Liau
New England Journal of Medicine 359 (5), 539-541, 2008
1642008
Comparison of glioma-associated antigen peptide-loaded versus autologous tumor lysate-loaded dendritic cell vaccination in malignant glioma patients
RM Prins, X Wang, H Soto, E Young, DN Lisiero, B Fong, R Everson, ...
Journal of immunotherapy 36 (2), 152-157, 2013
1452013
Immunosuppressive tumor-infiltrating myeloid cells mediate adaptive immune resistance via a PD-1/PD-L1 mechanism in glioblastoma
JP Antonios, H Soto, RG Everson, D Moughon, JR Orpilla, NP Shin, ...
Neuro-oncology 19 (6), 796-807, 2017
1442017
Enhanced antitumor activity induced by adoptive T-cell transfer and adjunctive use of the histone deacetylase inhibitor LAQ824
DD Vo, RM Prins, JL Begley, TR Donahue, LF Morris, KW Bruhn, ...
Cancer research 69 (22), 8693-8699, 2009
1412009
PD-1 blockade enhances the vaccination-induced immune response in glioma
JP Antonios, H Soto, RG Everson, J Orpilla, D Moughon, N Shin, ...
JCI insight 1 (10), 2016
1262016
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