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Christopher J. Schwalen
Christopher J. Schwalen
Novartis Institutes for BioMedical Research
Verifisert e-postadresse på novartis.com - Startside
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antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification
K Blin, T Wolf, MG Chevrette, X Lu, CJ Schwalen, SA Kautsar, ...
Nucleic acids research 45 (W1), W36-W41, 2017
12372017
A new genome-mining tool redefines the lasso peptide biosynthetic landscape
JI Tietz, CJ Schwalen, PS Patel, T Maxson, PM Blair, HC Tai, UI Zakai, ...
Nature chemical biology 13 (5), 470-478, 2017
4092017
YcaO-dependent posttranslational amide activation: biosynthesis, structure, and function
BJ Burkhart, CJ Schwalen, G Mann, JH Naismith, DA Mitchell
Chemical reviews 117 (8), 5389-5456, 2017
1722017
Bioinformatic Mapping of Radical S-Adenosylmethionine-Dependent Ribosomally Synthesized and Post-Translationally Modified Peptides Identifies New Cα, Cβ …
GA Hudson, BJ Burkhart, AJ DiCaprio, CJ Schwalen, B Kille, ...
Journal of the American Chemical Society 141 (20), 8228-8238, 2019
1372019
Bioinformatic expansion and discovery of thiopeptide antibiotics
CJ Schwalen, GA Hudson, B Kille, DA Mitchell
Journal of the American Chemical Society 140 (30), 9494-9501, 2018
1202018
In vitro biosynthetic studies of bottromycin expand the enzymatic capabilities of the YcaO superfamily
CJ Schwalen, GA Hudson, S Kosol, N Mahanta, GL Challis, DA Mitchell
Journal of the American Chemical Society 139 (50), 18154-18157, 2017
332017
Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin
JD Hegemann, CJ Schwalen, DA Mitchell, WA Van der Donk
Chemical communications 54 (65), 9007-9010, 2018
322018
An antibiotic from an uncultured bacterium binds to an immutable target
R Shukla, AJ Peoples, KC Ludwig, S Maity, MGN Derks, S De Benedetti, ...
Cell 186 (19), 4059-4073. e27, 2023
202023
Reprogramming nonribosomal peptide synthesis by surgical mutation
DL Niquille, DA Hansen, D Hilvert
Synlett 30 (19), 2123-2130, 2019
92019
Head‐to‐Head Prenyl Synthases in Pathogenic Bacteria
CJ Schwalen, X Feng, W Liu, B O‐Dowd, TP Ko, CJ Shin, RT Guo, ...
Chembiochem 18 (11), 985-991, 2017
72017
Discovery of Antibiotic Peptides from Novelty‐Prioritized Natural Product Genome Mining
CJ Schwalen, D Mitchell
The FASEB Journal 31, 939.8-939.8, 2017
22017
Scorpion α-toxin LqhαIT specifically interacts with a glycan at the pore domain of voltage-gated sodium channels
S Phulera, CJ Dickson, CJ Schwalen, M Khoshouei, SJ Cassell, Y Sun, ...
bioRxiv, 2024.01. 26.577479, 2024
2024
A new antibiotic from an uncultured bacterium binds to an immutable target
R Shukla, AJ Peoples, KC Ludwig, S Maity, MGN Derks, S de Benedetti, ...
bioRxiv, 2023
2023
Scalable Biosynthetic Production of Knotted Peptides Enables ADME and Thermodynamic Folding Studies
CJ Schwalen, C Babu, S Phulera, Q Hao, D Wall, DO Nettleton, TP Pathak, ...
ACS omega 6 (44), 29555-29566, 2021
2021
Correction to “Bioinformatic Mapping of Radical S-Adenosylmethionine-Dependent Ribosomally Synthesized and Post-Translationally Modified Peptides Identifies …
GA Hudson, BJ Burkhart, AJ DiCaprio, CJ Schwalen, B Kille, ...
Journal of the American Chemical Society 143 (27), 10479-10479, 2021
2021
Practical applications of genomics to natural product discovery and biosynthesis
CJ Schwalen
University of Illinois at Urbana-Champaign, 2017
2017
Award Address (National Fresenius Award, sponsored by Phi Lambda Upsilon, the National Chemistry Honor Society). Chemical and genomic tools to accelerate natural product discovery
D Mitchell, J Tietz, C Schwalen, C Cox, T Maxson, XR Gao
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 252, 2016
2016
Natural product engineering enabled by a YcaO-domain bottromycin macrocyclase
C Schwalen, P Blair, K Dunbar, D Mitchell
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 251, 2016
2016
Douglas A Mitchell
GA Hudson, JI Tietz, B Burkhart, C Schwalen
University of California, Berkeley 2006, 2002
2002
Cryo-EM studies on Nav Channel-modulator complexes
S Phulera, W Weihofen, J Whicher, M Khoshouei, C Schwalen
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Artikler 1–20