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Paul Titchenell
Paul Titchenell
Associate Professor, University of Pennsylvania
Verified email at pennmedicine.upenn.edu - Homepage
Title
Cited by
Cited by
Year
Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes
RJ Perry, JPG Camporez, R Kursawe, PM Titchenell, D Zhang, CJ Perry, ...
Cell 160 (4), 745-758, 2015
6912015
Unraveling the regulation of hepatic metabolism by insulin
PM Titchenell, MA Lazar, MJ Birnbaum
Trends in Endocrinology & Metabolism 28 (7), 497-505, 2017
3772017
Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate
S Zhao, C Jang, J Liu, K Uehara, M Gilbert, L Izzo, X Zeng, S Trefely, ...
Nature 579 (7800), 586-591, 2020
3502020
Direct hepatocyte insulin signaling is required for lipogenesis but is dispensable for the suppression of glucose production
PM Titchenell, WJ Quinn, M Lu, Q Chu, W Lu, C Li, H Chen, BR Monks, ...
Cell metabolism 23 (6), 1154-1166, 2016
2692016
Resolving the paradox of hepatic insulin resistance
D Santoleri, PM Titchenell
Cellular and molecular gastroenterology and hepatology 7 (2), 447-456, 2019
2282019
Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo
PM Titchenell, Q Chu, BR Monks, MJ Birnbaum
Nature communications 6 (1), 7078, 2015
1712015
The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver
K Patel, M Foretz, A Marion, DG Campbell, R Gourlay, N Boudaba, ...
Nature communications 5 (1), 4535, 2014
1712014
The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis
N Jaiswal, MG Gavin, WJ Quinn III, TS Luongo, RG Gelfer, JA Baur, ...
Molecular metabolism 28, 1-13, 2019
1312019
SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding
H Jang, GY Lee, CP Selby, G Lee, YG Jeon, JH Lee, KKY Cheng, ...
Nature communications 7 (1), 12180, 2016
792016
Novel atypical PKC inhibitors prevent vascular endothelial growth factor-induced blood–retinal barrier dysfunction
PM Titchenell, CM Lin, JM Keil, JM Sundstrom, CD Smith, DA Antonetti
Biochemical Journal 446 (3), 455-467, 2012
792012
mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion
WJ Quinn, M Wan, SV Shewale, R Gelfer, DJ Rader, MJ Birnbaum, ...
The Journal of clinical investigation 127 (11), 4207-4215, 2017
762017
Using the past to inform the future: anti-VEGF therapy as a road map to develop novel therapies for diabetic retinopathy
PM Titchenell, DA Antonetti
Diabetes 62 (6), 1808-1815, 2013
722013
Physiological suppression of lipotoxic liver damage by complementary actions of HDAC3 and SCAP/SREBP
R Papazyan, Z Sun, YH Kim, PM Titchenell, DA Hill, W Lu, M Damle, ...
Cell metabolism 24 (6), 863-874, 2016
692016
Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1
BS Gosis, S Wada, C Thorsheim, K Li, S Jung, JH Rhoades, Y Yang, ...
Science 376 (6590), eabf8271, 2022
642022
Early B cell factor activity controls developmental and adaptive thermogenic gene programming in adipocytes
AR Angueira, SN Shapira, J Ishibashi, S Sampat, J Sostre-Colón, ...
Cell reports 30 (9), 2869-2878. e4, 2020
432020
Shared PPARα/γ target genes regulate brown adipocyte thermogenic function
Y Shen, Y Su, FJ Silva, AH Weller, J Sostre-Colón, PM Titchenell, ...
Cell reports 30 (9), 3079-3091. e5, 2020
342020
AKT controls protein synthesis and oxidative metabolism via combined mTORC1 and FOXO1 signalling to govern muscle physiology
N Jaiswal, M Gavin, E Loro, J Sostre‐Colón, PA Roberson, K Uehara, ...
Journal of cachexia, sarcopenia and muscle 13 (1), 495-514, 2022
322022
MondoA drives muscle lipid accumulation and insulin resistance
B Ahn, S Wan, N Jaiswal, RB Vega, DE Ayer, PM Titchenell, X Han, ...
JCI insight 4 (15), 2019
262019
Inhibition of atypical protein kinase C reduces inflammation-induced retinal vascular permeability
C Lin, PM Titchenell, JM Keil, A Garcia-Ocaña, MT Bolinger, SF Abcouwer, ...
The American journal of pathology 188 (10), 2392-2405, 2018
242018
Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and-independent mechanisms
J Sostre-Colón, K Uehara, AEG Whitlock, MJ Gavin, J Ishibashi, ...
Cell reports 35 (7), 2021
182021
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