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Gregg L. Semenza
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
autophagy 17 (1), 1-382, 2021
11199*2021
Targeting HIF-1 for cancer therapy
GL Semenza
Nature reviews cancer 3 (10), 721-732, 2003
74442003
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
GL Wang, BH Jiang, EA Rue, GL Semenza
Proceedings of the national academy of sciences 92 (12), 5510-5514, 1995
71551995
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
JA Forsythe, BH Jiang, NV Iyer, F Agani, SW Leung, RD Koos, ...
Molecular and cellular biology 16 (9), 4604-4613, 1996
46261996
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
GL Semenza, GL Wang
Molecular and cellular biology 12 (12), 5447-5454, 1992
36891992
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
J Kim, I Tchernyshyov, GL Semenza, CV Dang
Cell metabolism 3 (3), 177-185, 2006
35972006
HIF-1: mediator of physiological and pathophysiological responses to hypoxia
GL Semenza
Journal of applied physiology, 2000
3490*2000
Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases
H Zhong, AM De Marzo, E Laughner, M Lim, DA Hilton, D Zagzag, ...
Cancer research 59 (22), 5830-5835, 1999
34501999
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α
NV Iyer, LE Kotch, F Agani, SW Leung, E Laughner, RH Wenger, ...
Genes & development 12 (2), 149-162, 1998
29411998
Hypoxia-inducible factors in physiology and medicine
GL Semenza
Cell 148 (3), 399-408, 2012
27202012
Purification and Characterization of Hypoxia-inducible Factor 1 (∗)
GL Wang, GL Semenza
Journal of biological chemistry 270 (3), 1230-1237, 1995
25641995
Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1
GL Semenza
Annual review of cell and developmental biology 15, 551, 1999
24201999
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.
GL Semenza, PH Roth, HM Fang, GL Wang
Journal of biological chemistry 269 (38), 23757-23763, 1994
21651994
Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells …
H Zhong, K Chiles, D Feldser, E Laughner, C Hanrahan, MM Georgescu, ...
Cancer research 60 (6), 1541-1545, 2000
19812000
Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
GL Semenza, BH Jiang, SW Leung, R Passantino, JP Concordet, P Maire, ...
Journal of Biological Chemistry 271 (51), 32529-32537, 1996
19611996
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
GL Semenza
Oncogene 29 (5), 625-634, 2010
18412010
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
GL Wang, GL Semenza
Proceedings of the National Academy of Sciences 90 (9), 4304-4308, 1993
17571993
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
H Zhang, M Bosch-Marce, LA Shimoda, YS Tan, JH Baek, JB Wesley, ...
Journal of Biological Chemistry 283 (16), 10892-10903, 2008
17162008
FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
PC Mahon, K Hirota, GL Semenza
Genes & development 15 (20), 2675-2686, 2001
16812001
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
E Laughner, P Taghavi, K Chiles, PC Mahon, GL Semenza
Molecular and cellular biology 21 (12), 3995-4004, 2001
16012001
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