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Jonathan K. Watts
Jonathan K. Watts
Professor, RNA Therapeutics Institute, UMass Chan Medical School
Verifisert e-postadresse på umassmed.edu - Startside
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The chemical evolution of oligonucleotide therapies of clinical utility
A Khvorova, JK Watts
Nature biotechnology 35 (3), 238-248, 2017
8942017
Chemically modified siRNA: tools and applications
JK Watts, GF Deleavey, MJ Damha
Drug discovery today 13 (19-20), 842-855, 2008
5172008
Silencing disease genes in the laboratory and the clinic
JK Watts, DR Corey
The Journal of pathology 226 (2), 365-379, 2012
493*2012
Enhancer RNA facilitates NELF release from immediate early genes
K Schaukowitch, JY Joo, X Liu, JK Watts, C Martinez, TK Kim
Molecular cell 56 (1), 29-42, 2014
4332014
RNA therapeutics on the rise
F Wang, T Zuroske, JK Watts
Nature Reviews Drug Discovery 19, 441-442, 2020
1742020
Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing
GF Deleavey, JK Watts, T Alain, F Robert, A Kalota, V Aishwarya, ...
Nucleic acids research 38 (13), 4547-4557, 2010
1132010
2′-Fluoro-4′-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity
JK Watts, N Choubdar, K Sadalapure, F Robert, AS Wahba, J Pelletier, ...
Nucleic acids research 35 (5), 1441-1451, 2007
1042007
Energetically important C− H··· F− C pseudohydrogen bonding in water: evidence and application to rational design of oligonucleotides with high binding affinity
MY Anzahaee, JK Watts, NR Alla, AW Nicholson, MJ Damha
Journal of the American Chemical Society 133 (4), 728-731, 2011
1032011
Oligonucleotide therapeutics: chemistry, delivery and clinical progress
VK Sharma, JK Watts
Future medicinal chemistry 7 (16), 2221-2242, 2015
1012015
Clinical status of duplex RNA
JK Watts, DR Corey
Bioorganic & medicinal chemistry letters 20 (11), 3203-3207, 2010
902010
Chemical modification of siRNA
GF Deleavey, JK Watts, MJ Damha
Current Protocols in Nucleic Acid Chemistry 39 (1), 16.3. 1-16.3. 22, 2009
862009
The NIH somatic cell genome editing program
K Saha, EJ Sontheimer, PJ Brooks, MR Dwinell, CA Gersbach, DR Liu, ...
Nature 592 (7853), 195-204, 2021
822021
Differential stability of 2′ F-ANA• RNA and ANA• RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility
JK Watts, N Martín-Pintado, I Gomez-Pinto, J Schwartzentruber, G Portella, ...
Nucleic acids research 38 (7), 2498-2511, 2010
822010
Generation of novel hybrid aptamer–molecularly imprinted polymeric nanoparticles
A Poma, H Brahmbhatt, HM Pendergraff, JK Watts, NW Turner
Advanced Materials 27 (4), 750-758, 2015
782015
Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing
A Mir, JF Alterman, MR Hassler, AJ Debacker, E Hudgens, D Echeverria, ...
Nature Communications 9, 2641, 2018
772018
2′ F-Arabinonucleic acids (2′ F-ANA)—History, properties, and new frontiers
JK Watts, MJ Damha
Canadian Journal of Chemistry 86 (7), 641-656, 2008
742008
Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide
H Tran, MP Moazami, H Yang, D McKenna-Yasek, CL Douthwright, ...
Nature medicine 28 (1), 117-124, 2022
712022
Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs
J Hu, KT Gagnon, J Liu, JK Watts, J Syeda-Nawaz, CF Bennett, ...
Walter de Gruyter 392 (4), 315-325, 2011
682011
Studies on the hydrolytic stability of 2′-fluoroarabinonucleic acid (2′ F-ANA)
JK Watts, A Katolik, J Viladoms, MJ Damha
Organic & Biomolecular Chemistry 7 (9), 1904-1910, 2009
642009
Locked nucleic acid: tighter is different
JK Watts
Chemical Communications 49 (50), 5618-5620, 2013
582013
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Artikler 1–20