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Shasha Li
Shasha Li
S. Scientist at Merck, Chemistry; PhD of Pharmacy, University of Michigan, Ann Arbor
Verifisert e-postadresse på umich.edu - Startside
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Inversion of extender unit selectivity in the erythromycin polyketide synthase by acyltransferase domain engineering
I Koryakina, C Kasey, JB McArthur, AN Lowell, JA Chemler, S Li, ...
ACS chemical biology 12 (1), 114-123, 2017
772017
Hapalindole/ambiguine biogenesis is mediated by a Cope rearrangement, C–C bond-forming cascade
S Li, AN Lowell, F Yu, A Raveh, SA Newmister, N Bair, JM Schaub, ...
Journal of the American Chemical Society 137 (49), 15366-15369, 2015
702015
High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein–Protein Interaction
H Zhou, W Zhou, B Zhou, L Liu, TR Chern, K Chinnaswamy, J Lu, ...
Journal of medicinal chemistry 61 (5), 1934-1950, 2018
542018
Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids
S Li, AN Lowell, SA Newmister, F Yu, RM Williams, DH Sherman
Nature chemical biology 13 (5), 467-469, 2017
372017
Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors
C Zhang, S Li, L Ji, S Liu, Z Li, S Li, X Meng
Bioorganic & medicinal chemistry letters 25 (20), 4693-4696, 2015
352015
Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis
SA Newmister, S Li, M Garcia-Borràs, JN Sanders, S Yang, AN Lowell, ...
Nature chemical biology 14 (4), 345-351, 2018
332018
The novel triazolonaphthalimide derivative LSS-11 synergizes the anti-proliferative effect of paclitaxel via STAT3-dependent MDR1 and MRP1 downregulation in chemoresistant lung …
L Ji, X Liu, S Zhang, S Tang, S Yang, S Li, X Qi, S Yu, L Lu, X Meng, Z Liu
Molecules 22 (11), 1822, 2017
242017
Multi-component microscale biosynthesis of unnatural cyanobacterial indole alkaloids
Y Khatri, RM Hohlman, J Mendoza, S Li, AN Lowell, H Asahara, ...
ACS Synthetic Biology, 2020
232020
A novel triazolonaphthalimide induces apoptosis and inhibits tumor growth by targeting DNA and DNA-associated processes
L Ji, S Yang, S Li, S Liu, S Tang, Z Liu, X Meng, S Yu
Oncotarget 8 (23), 37394, 2017
152017
Unprecedented synthesis, in vitro and in vivo anti-cancer evaluation of novel triazolonaphthalimide derivatives
S Li, W Zhong, Z Li, X Meng
European journal of medicinal chemistry 47, 546-552, 2012
142012
Merging Late-Stage Diversification with Solid-Phase Peptide Synthesis Enabled by High-Throughput On-Resin Reaction Screening
S Li, D Pissarnitski, T Nowak, M Wleklinski, SW Krska
ACS Catalysis 12, 3201-3210, 2022
72022
Structural Diversification of Hapalindole and Fischerindole Natural Products via Cascade Biocatalysis
RM Hohlman, SA Newmister, JN Sanders, Y Khatri, S Li, NR Keramati, ...
ACS Catalysis 11 (8), 4670-4681, 2021
62021
Synthesis and Cytotoxicity Evaluation of Naphthalimide Derived N-Mustards
Q Lou, L Ji, W Zhong, S Li, S Yu, Z Li, X Meng
Molecules 19 (7), 8803-8819, 2014
42014
Control of Stereoselectivity in Diverse Hapalindole Metabolites is Mediated by Cofactor‐Induced Combinatorial Pairing of Stig Cyclases
S Li, SA Newmister, AN Lowell, J Zi, CR Chappell, F Yu, RM Hohlman, ...
Angewandte Chemie International Edition 59 (21), 8166-8172, 2020
32020
Structural basis of the Cope rearrangement and C− C bond-forming cascade in hapalindole/fischerindole biogenesis
SA Newmister, S Li, M Garcia-Borràs, JN Sanders, S Yang, AN Lowell, ...
bioRxiv, 173674, 2017
22017
Function and structure of a new class of indole alkaloid cyclases in the Stigonematales cyanobacteria
D Sherman, S Li, S Newmister, A Lowell, F Yu
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 254, 2017
2017
Biocatalyst discovery from the secondary metabolome
DH Sherman, S Li, AN Lowell, SA Newmister, F Yu, RM Williams
The FASEB Journal 31 (1_supplement), 528.2-528.2, 2017
2017
Decoding the Bio-Assembly of Hapalindole-Type Alkaloids from Cyanobacteria for Drug Discovery
S Li
2017
Hapalindole-type alkaloids from cyanobacteria: Characterization of biosynthetic pathway for drug discovery
S Li, A Lowell, F Yu, A Raveh, S Newmister, N Bair, J Schaub, R Williams, ...
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 252, 2016
2016
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Artikler 1–19