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David Orlando
David Orlando
MOMA Therapeutics
Verifisert e-postadresse på momatx.com
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Master transcription factors and mediator establish super-enhancers at key cell identity genes
WA Whyte, DA Orlando, D Hnisz, BJ Abraham, CY Lin, MH Kagey, ...
Cell 153 (2), 307-319, 2013
31502013
Selective inhibition of tumor oncogenes by disruption of super-enhancers
J Lovén, HA Hoke, CY Lin, A Lau, DA Orlando, CR Vakoc, JE Bradner, ...
Cell 153 (2), 320-334, 2013
23682013
Mediator and cohesin connect gene expression and chromatin architecture
MH Kagey, JJ Newman, S Bilodeau, Y Zhan, DA Orlando, NL van Berkum, ...
Nature 467 (7314), 430-435, 2010
20382010
A high-resolution root spatiotemporal map reveals dominant expression patterns
SM Brady, DA Orlando, JY Lee, JY Wang, J Koch, JR Dinneny, D Mace, ...
Science 318 (5851), 801-806, 2007
11502007
Master transcription factors determine cell-type-specific responses to TGF-β signaling
AC Mullen, DA Orlando, JJ Newman, J Lovén, RM Kumar, S Bilodeau, ...
Cell 147 (3), 565-576, 2011
6182011
Revisiting global gene expression analysis
J Lovén, DA Orlando, AA Sigova, CY Lin, PB Rahl, CB Burge, DL Levens, ...
Cell 151 (3), 476-482, 2012
6102012
Enhancer decommissioning by LSD1 during embryonic stem cell differentiation
WA Whyte, S Bilodeau, DA Orlando, HA Hoke, GM Frampton, CT Foster, ...
Nature 482 (7384), 221-225, 2012
5712012
The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset
CJ Ceol, Y Houvras, J Jane-Valbuena, S Bilodeau, DA Orlando, V Battisti, ...
Nature 471 (7339), 513-517, 2011
5582011
Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells
AA Sigova, AC Mullen, B Molinie, S Gupta, DA Orlando, MG Guenther, ...
Proceedings of the National Academy of Sciences 110 (8), 2876-2881, 2013
4672013
Quantitative ChIP-Seq normalization reveals global modulation of the epigenome
DA Orlando, MW Chen, VE Brown, S Solanki, YJ Choi, ER Olson, CC Fritz, ...
Cell reports 9 (3), 1163-1170, 2014
4002014
Global control of cell-cycle transcription by coupled CDK and network oscillators
DA Orlando, CY Lin, A Bernard, JY Wang, JES Socolar, ES Iversen, ...
Nature 453 (7197), 944-947, 2008
3482008
Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons
Y Li, H Wang, J Muffat, AW Cheng, DA Orlando, J Lovén, S Kwok, ...
Cell stem cell 13 (4), 446-458, 2013
3152013
Protonophore‐and pH‐insensitive glucose and sucrose accumulation detected by FRET nanosensors in Arabidopsis root tips
B Chaudhuri, F Hörmann, S Lalonde, SM Brady, DA Orlando, P Benfey, ...
The Plant Journal 56 (6), 948-962, 2008
1182008
Multiple structural maintenance of chromosome complexes at transcriptional regulatory elements
JM Dowen, S Bilodeau, DA Orlando, MR Hübner, BJ Abraham, ...
Stem cell reports 1 (5), 371-378, 2013
1142013
Superenhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML, Including an RARα Dependency Targetable by SY-1425, a Potent and Selective RARα AgonistSuperenhancer …
MR McKeown, MR Corces, ML Eaton, C Fiore, E Lee, JT Lopez, ...
Cancer discovery 7 (10), 1136-1153, 2017
992017
Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7Discovery and Characterization of a CDK7 Inhibitor SY-1365
S Hu, JJ Marineau, N Rajagopal, KB Hamman, YJ Choi, DR Schmidt, ...
Cancer research 79 (13), 3479-3491, 2019
772019
Cyclin-Dependent Kinases Are Regulators and Effectors of Oscillations Driven by a Transcription Factor Network
LAS Kovacs, MB Mayhew, DA Orlando, Y Jin, Q Li, C Huang, SI Reed, ...
Molecular Cell 49 (6), 1177-1179, 2013
742013
Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network
LAS Kovacs, MB Mayhew, DA Orlando, Y Jin, Q Li, C Huang, SI Reed, ...
Molecular cell 45 (5), 669-679, 2012
742012
Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network
LAS Kovacs, MB Mayhew, DA Orlando, Y Jin, Q Li, C Huang, SI Reed, ...
Molecular cell 45 (5), 669-679, 2012
742012
Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network
LAS Kovacs, MB Mayhew, DA Orlando, Y Jin, Q Li, C Huang, SI Reed, ...
Molecular cell 45 (5), 669-679, 2012
742012
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Artikler 1–20