IRG and GBP host resistance factors target aberrant,“non-self” vacuoles characterized by the missing of “self” IRGM proteins AK Haldar, HA Saka, AS Piro, JD Dunn, SC Henry, GA Taylor, EM Frickel, ... PLoS Pathog 9 (6), e1003414, 2013 | 188 | 2013 |
Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins AK Haldar, C Foltz, R Finethy, AS Piro, EM Feeley, DM Pilla-Moffett, ... Proceedings of the National Academy of Sciences 112 (41), E5628-E5637, 2015 | 163 | 2015 |
Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems EM Feeley, DM Pilla-Moffett, EE Zwack, AS Piro, R Finethy, JP Kolb, ... Proceedings of the National Academy of Sciences 114 (9), E1698-E1706, 2017 | 137 | 2017 |
Detection of cytosolic Shigella flexneri via a C-terminal triple-arginine motif of GBP1 inhibits actin-based motility AS Piro, D Hernandez, S Luoma, EM Feeley, R Finethy, A Yirga, ... MBio 8 (6), 2017 | 99 | 2017 |
The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia-and Toxoplasma-containing vacuoles and host resistance AK Haldar, AS Piro, DM Pilla, M Yamamoto, J Coers PloS one 9 (1), e86684, 2014 | 94 | 2014 |
Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii AC Johnston, A Piro, B Clough, M Siew, S Virreira Winter, J Coers, ... Cellular microbiology 18 (8), 1056-1064, 2016 | 78 | 2016 |
Small region of Rtf1 protein can substitute for complete Paf1 complex in facilitating global histone H2B ubiquitylation in yeast AS Piro, MK Mayekar, MH Warner, CP Davis, KM Arndt Proceedings of the National Academy of Sciences 109 (27), 10837-10842, 2012 | 70 | 2012 |
Chlamydia trachomatis is resistant to inclusion ubiquitination and associated host defense in gamma interferon-primed human epithelial cells AK Haldar, AS Piro, R Finethy, ST Espenschied, HE Brown, AM Giebel, ... MBio 7 (6), 2016 | 53 | 2016 |
Dynamin-related Irgm proteins modulate LPS-induced caspase-4 activation and septic shock R Finethy, J Dockterman, M Kutsch, N Orench-Rivera, G Wallace, A Piro, ... bioRxiv, 2020 | 44 | 2020 |
A rapidly evolving polybasic motif modulates bacterial detection by guanylate binding proteins KM Kohler, M Kutsch, AS Piro, GD Wallace, J Coers, MF Barber Mbio 11 (3), 2020 | 19 | 2020 |
The Role of Human Guanylate Binding Proteins in Host Defense and Inflammation AS Piro Duke University, 2018 | | 2018 |
IMMUNITY RELATED GTPASES CONTROL CASPASE-11 ACTIVITY TO PROTECT AGAINST SEPTIC SHOCK: P145 R Finethy, A Piro, A Haldar, G Taylor, J Coers Cytokine 87, 2016 | | 2016 |
GALECTIN 3 FACILITATES RECRUITMENT OF THE GUANYLATE BINDING PROTEINS TO THE PATHOGEN CONTAINING VACUOLE: P065 E Feeley, D Pilla-Moffett, A Piro, R Finethy, J Coers Cytokine 87, 2016 | | 2016 |