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Merck & Co., Inc.
Merck & Co., Inc.
MERCK SHARP AND DOHME CORP
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Molecular mechanism of SHP2 activation by PD-1 stimulation
M Marasco, A Berteotti, J Weyershaeuser, N Thorausch, J Sikorska, ...
Science advances 6 (5), eaay4458, 2020
1802020
Apratoxin H and Apratoxin A Sulfoxide from the Red Sea Cyanobacterium Moorea producens
CC Thornburg, ES Cowley, J Sikorska, LA Shaala, JE Ishmael, ...
Journal of natural products 76 (9), 1781-1788, 2013
1112013
Mandelalides A–D, Cytotoxic Macrolides from a New Lissoclinum Species of South African Tunicate
J Sikorska, AM Hau, C Anklin, S Parker-Nance, MT Davies-Coleman, ...
The Journal of organic chemistry 77 (14), 6066-6075, 2012
992012
Mandelalides A–D, Cytotoxic Macrolides from a New Lissoclinum Species of South African Tunicate
J Sikorska, AM Hau, C Anklin, S Parker-Nance, MT Davies-Coleman, ...
The Journal of organic chemistry 77 (14), 6066-6075, 2012
992012
Antimicrobial Rubrolides from a South African Species of Synoicum Tunicate
J Sikorska, S Parker-Nance, MT Davies-Coleman, OB Vining, AE Sikora, ...
Journal of natural products 75 (10), 1824-1827, 2012
632012
Phosphotyrosine couples peptide binding and SHP2 activation via a dynamic allosteric network
M Marasco, J Kirkpatrick, V Nanna, J Sikorska, T Carlomagno
Computational and structural biotechnology journal 19, 2398-2415, 2021
302021
Apoptolidins A and C activate AMPK in metabolically sensitive cell types and are mechanistically distinct from oligomycin A
JD Serrill, M Tan, S Fotso, J Sikorska, N Kasanah, AM Hau, KL McPhail, ...
Biochemical pharmacology 93 (3), 251-265, 2015
222015
Discovery of mandelalide E and determinants of cytotoxicity for the mandelalide series
M Nazari, JD Serrill, J Sikorska, T Ye, JE Ishmael, KL McPhail
Organic letters 18 (6), 1374-1377, 2016
202016
Towards theory driven structure elucidation of complex natural products: mandelalides and coibamide A
KM Snyder, J Sikorska, T Ye, L Fang, W Su, RG Carter, KL McPhail, ...
Organic & Biomolecular Chemistry 14 (24), 5826-5831, 2016
202016
Molecular mechanism of SHP2 activation by PD-1 stimulation. Sci Adv. 2020; 6 (5): eaay4458
M Marasco, A Berteotti, J Weyershaeuser, N Thorausch, J Sikorska, ...
Epub 2020/02/18. doi: 10.1126/sciadv. aay4458.[PubMed: 32064351], 0
5
Identification of new hit scaffolds by INPHARMA-guided virtual screening
J Sikorska, L Codutti, L Skjærven, B Elshorst, R Saez-Ameneiro, ...
MedChemComm 6 (8), 1501-1507, 2015
42015
Understanding of Protein-Ligand Interactions with INPHARMA
J Sikorska, L Codutti, RS Ameneiro, L Skjaerven, A Angelini, ...
Planta Medica 79 (10), PD2, 2013
12013
Characterization of RNA driven structural changes in full length RIG-I leading to its agonism or antagonism
J Sikorska, Y Hou, P Chiurazzi, T Siu, GA Baltus, P Sheth, DG McLaren, ...
Nucleic Acids Research 51 (17), 9356-9368, 2023
2023
New and known mandelalides for biological mechanism and structure-activity relationship studies
M Nazari, K Snyder, HCP Cheong, J Sikorska, JD Serrill, JE Ishmael, ...
Planta Medica 81 (11), PQ33, 2015
2015
Apratoxin H, a Cytotoxic Cyclic Depsipeptide from a Red Sea Moorea producens Cyanobacterium
CC Thornburg, ES Cowley, J Sikorska, LA Shaala, JE Ishmael, ...
Investigation of Unique Marine Environments for Microbial Natural Products …, 2013
2013
Application of modern NMR techniques to structure elucidation of bioactive natural products from tunicates
J Sikorska
2012
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Artikler 1–16