Carsten Uhd Nielsen
Carsten Uhd Nielsen
Department of Physics, Chemistry and Pharmacy, Faculty of Sciences, University of Southern Denmark
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Intestinal solute carriers: an overview of trends and strategies for improving oral drug absorption
B Steffansen, CU Nielsen, B Brodin, AH Eriksson, R Andersen, S Frokjaer
European journal of pharmaceutical sciences 21 (1), 3-16, 2004
Transport of peptidomimetic drugs by the intestinal di/tri‐peptide transporter, PepT1
B Brodin, CU Nielsen, B Steffansen, S Frøkjær
Pharmacology & toxicology 90 (6), 285-296, 2002
Epidermal growth factor inhibits glycylsarcosine transport and hPepT1 expression in a human intestinal cell line
CU Nielsen, J Amstrup, B Steffansen, S Frokjaer, B Brodin
American Journal of Physiology-Gastrointestinal and Liver Physiology 281 (1 …, 2001
Genetic variants of the human H+/dipeptide transporter PEPT2: analysis of haplotype functions
J Pinsonneault, CU Nielsen, W Sadée
Journal of Pharmacology and Experimental Therapeutics 311 (3), 1088-1096, 2004
Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line
CU Nielsen, R Andersen, B Brodin, S Frokjaer, ME Taub, B Steffansen
Journal of controlled release 76 (1-2), 129-138, 2001
Di/tri-peptide transporters as drug delivery targets: regulation of transport under physiological and patho-physiological conditions
CU Nielsen, B Brodin
Current drug targets 4 (5), 373-388, 2003
In vitro evidence for the brain glutamate efflux hypothesis: Brain endothelial cells cocultured with astrocytes display a polarized brain‐to‐blood transport of glutamate
HC Helms, R Madelung, HS Waagepetersen, CU Nielsen, B Brodin
Glia 60 (6), 882-893, 2012
Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics
CW Botka, TW Wittig, RC Graul, CU Nielsen, W Sadée, K Higaki, ...
AAPS PharmSci 2 (2), 76-97, 2000
Passive diffusion of drug substances: the concepts of flux and permeability
B Brodin, B Steffansen, CU Nielsen
Molecular Biopharmaceutics, 135-152, 2010
Paracellular tightness and claudin-5 expression is increased in the BCEC/astrocyte blood–brain barrier model by increasing media buffer capacity during growth
HC Helms, HS Waagepetersen, CU Nielsen, B Brodin
The AAPS journal 12 (4), 759-770, 2010
Model prodrugs designed for the intestinal peptide transporter. A synthetic approach for coupling of hydroxy-containing compounds to dipeptides
GM Friedrichsen, CU Nielsen, B Steffansen, M Begtrup
European journal of pharmaceutical sciences 14 (1), 13-19, 2001
Human peptide transporters: therapeutic applications
CU Nielsen, B Brodin, FS Jørgensen, S Frokjaer, B Steffansen
Expert Opinion on Therapeutic Patents 12 (9), 1329-1350, 2002
Phe-Gly dipeptidomimetics designed for the di-/tripeptide transporters PEPT1 and PEPT2: synthesis and biological investigations
J Våbenø, T Lejon, CU Nielsen, B Steffansen, W Chen, H Ouyang, ...
Journal of medicinal chemistry 47 (4), 1060-1069, 2004
Genetic variants of the human dipeptide transporter PEPT1
P Anderle, CU Nielsen, J Pinsonneault, PL Krog, B Brodin, W Sadée
Journal of Pharmacology and Experimental Therapeutics 316 (2), 636-646, 2006
Epidermal growth factor and insulin short‐term increase hPepT1‐mediated glycylsarcosine uptake in Caco‐2 cells
CU Nielsen, J Amstrup, R Nielsen, B Steffansen, S Frokjaer, B Brodin
Acta physiologica scandinavica 178 (2), 139-148, 2003
An electrically tight in vitro blood–brain barrier model displays net brain-to-blood efflux of substrates for the ABC transporters, P-gp, Bcrp and Mrp-1
HC Helms, M Hersom, LB Kuhlmann, L Badolo, CU Nielsen, B Brodin
The AAPS journal 16 (5), 1046-1055, 2014
δ‐Aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1)
S Frølund, OC Marquez, M Larsen, B Brodin, CU Nielsen
British journal of pharmacology 159 (6), 1339-1353, 2010
In-depth evaluation of Gly-Sar transport parameters as a function of culture time in the Caco-2 cell model
SA Bravo, CU Nielsen, J Amstrup, S Frokjaer, B Brodin
European journal of pharmaceutical sciences 21 (1), 77-86, 2004
Delivery aspects of small peptides and substrates for peptide transporters
B Steffansen, CU Nielsen, S Frokjaer
European journal of pharmaceutics and biopharmaceutics 60 (2), 241-245, 2005
Dipeptidomimetic ketomethylene isosteres as pro-moieties for drug transport via the human intestinal di-/tripeptide transporter hPEPT1: design, synthesis, stability, and …
J Våbenø, CU Nielsen, T Ingebrigtsen, T Lejon, B Steffansen, K Luthman
Journal of medicinal chemistry 47 (19), 4755-4765, 2004
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