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Jo Waaler
Jo Waaler
Oslo University Hospital
Verifisert e-postadresse på rr-research.no
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A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant MiceJW55 Inhibits Wnt Signaling and …
J Waaler, O Machon, L Tumova, H Dinh, V Korinek, SR Wilson, ...
Cancer research 72 (11), 2822-2832, 2012
3362012
A novel tankyrase small-molecule inhibitor suppresses APC mutation–driven colorectal tumor growth
T Lau, E Chan, M Callow, J Waaler, J Boggs, RA Blake, S Magnuson, ...
Cancer research 73 (10), 3132-3144, 2013
2992013
Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth
J Waaler, O Machon, JP von Kries, SR Wilson, E Lundenes, D Wedlich, ...
Cancer research 71 (1), 197-205, 2011
1622011
Structural basis and SAR for G007-LK, a lead stage 1, 2, 4-triazole based specific tankyrase 1/2 inhibitor
A Voronkov, DD Holsworth, J Waaler, SR Wilson, B Ekblad, ...
Journal of medicinal chemistry 56 (7), 3012-3023, 2013
1222013
The tankyrase‐specific inhibitor JW 74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines
E Wessel Stratford, J Daffinrud, E Munthe, R Castro, J Waaler, S Krauss, ...
Cancer medicine 3 (1), 36-46, 2014
542014
Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced DegradasomesTankyrase Inhibitor-Induced WNT Destruction Complexes
TE Thorvaldsen, NM Pedersen, EM Wenzel, SW Schultz, A Brech, ...
Molecular Cancer Research 13 (11), 1487-1501, 2015
452015
Versatile, sensitive liquid chromatography mass spectrometry–Implementation of 10 μm OT columns suitable for small molecules, peptides and proteins
T Vehus, H Roberg-Larsen, J Waaler, S Aslaksen, S Krauss, SR Wilson, ...
Scientific reports 6 (1), 1-10, 2016
402016
TANKYRASE Inhibition Enhances the Antiproliferative Effect of PI3K and EGFR Inhibition, Mutually Affecting β-CATENIN and AKT Signaling in Colorectal CancerCross-talk between …
NT Solberg, J Waaler, K Lund, L Mygland, PA Olsen, S Krauss
Molecular Cancer Research 16 (3), 543-553, 2018
362018
The PARsylation activity of tankyrase in adipose tissue modulates systemic glucose metabolism in mice
L Zhong, Y Ding, G Bandyopadhyay, J Waaler, E Börgeson, S Smith, ...
Diabetologia 59 (3), 582-591, 2016
352016
Discovery of a novel series of tankyrase inhibitors by a hybridization approach
UR Anumala, J Waaler, Y Nkizinkiko, A Ignatev, K Lazarow, P Lindemann, ...
Journal of Medicinal Chemistry 60 (24), 10013-10025, 2017
342017
Development and structural analysis of adenosine site binding tankyrase inhibitors
T Haikarainen, J Waaler, A Ignatev, Y Nkizinkiko, H Venkannagari, ...
Bioorganic & Medicinal Chemistry Letters 26 (2), 328-333, 2016
222016
Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models
J Waaler, L Mygland, A Tveita, MF Strand, NT Solberg, PA Olsen, ...
Communications biology 3 (1), 1-13, 2020
202020
The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology
JH Norum, E Skarpen, A Brech, R Kuiper, J Waaler, S Krauss, T Sørlie
Biological research 51 (1), 1-13, 2018
202018
Preclinical lead optimization of a 1, 2, 4-triazole based tankyrase inhibitor
J Waaler, RGG Leenders, ST Sowa, S Alam Brinch, M Lycke, P Nieczypor, ...
Journal of medicinal chemistry 63 (13), 6834-6846, 2020
162020
Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice
H Wang, S Kuusela, R Rinnankoski-Tuikka, V Dumont, R Bouslama, ...
International Journal of Obesity 44 (8), 1691-1702, 2020
142020
A small-molecule tankyrase inhibitor reduces glioma stem cell proliferation and sphere formation
KS Kierulf-Vieira, CJ Sandberg, J Waaler, K Lund, E Skaga, ...
Cancers 12 (6), 1630, 2020
122020
Development of a 1, 2, 4-triazole-based lead tankyrase inhibitor: part II
RGG Leenders, SA Brinch, ST Sowa, E Amundsen-Isaksen, A Galera-Prat, ...
Journal of medicinal chemistry 64 (24), 17936-17949, 2021
72021
Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines
L Mygland, SA Brinch, MF Strand, PA Olsen, A Aizenshtadt, K Lund, ...
Iscience 24 (7), 102807, 2021
52021
The Tankyrase Inhibitor OM-153 Demonstrates Antitumor Efficacy and a Therapeutic Window in Mouse Models
SA Brinch, E Amundsen-Isaksen, S Espada, C Hammarström, ...
Cancer Research Communications 2 (4), 233-245, 2022
12022
Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation
VT Lien, MK Kristiansen, S Pettersen, MH Haugen, DE Olberg, J Waaler, ...
RSC advances 9 (63), 37092-37100, 2019
12019
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Artikler 1–20