David L. Zechel
David L. Zechel
Queen's University, Dept. of Chemistry
Verifisert e-postadresse på chem.queensu.ca - Startside
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Glycosidase mechanisms: anatomy of a finely tuned catalyst
DL Zechel, SG Withers
Accounts of chemical research 33 (1), 11-18, 2000
9972000
Mapping the conformational itinerary of β-glycosidases by X-ray crystallography
GJ Davies, VMA Ducros, A Varrot, DL Zechel
Biochemical Society Transactions 31 (3), 523-527, 2003
1972003
Phosphonate biochemistry
GP Horsman, DL Zechel
Chemical reviews 117 (8), 5704-5783, 2017
1792017
Dissection of nucleophilic and acid–base catalysis in glycosidases
DL Zechel, SG Withers
Current opinion in chemical biology 5 (6), 643-649, 2001
1772001
Iminosugar glycosidase inhibitors: structural and thermodynamic dissection of the binding of isofagomine and 1-deoxynojirimycin to β-glucosidases
DL Zechel, AB Boraston, T Gloster, CM Boraston, JM Macdonald, ...
Journal of the American Chemical Society 125 (47), 14313-14323, 2003
1762003
The E358S mutant of Agrobacterium sp. β‐glucosidase is a greatly improved glycosynthase
C Mayer, DL Zechel, SP Reid, RAJ Warren, SG Withers
FEBS letters 466 (1), 40-44, 2000
1542000
Substrate Distortion by a β‐Mannanase: Snapshots of the Michaelis and Covalent‐Intermediate Complexes Suggest a B2,5 Conformation for the Transition State
VMA Ducros, DL Zechel, GN Murshudov, HJ Gilbert, L Szabó, D Stoll, ...
Angewandte Chemie International Edition 41 (15), 2824-2827, 2002
1502002
Glycosidase inhibition: an assessment of the binding of 18 putative transition-state mimics
TM Gloster, P Meloncelli, RV Stick, D Zechel, A Vasella, GJ Davies
Journal of the American Chemical Society 129 (8), 2345-2354, 2007
1342007
β‐Mannosynthase: Synthesis of β‐Mannosides with a Mutant β‐Mannosidase
O Nashiru, DL Zechel, D Stoll, T Mohammadzadeh, RAJ Warren, ...
Angewandte Chemie International Edition 40 (2), 417-420, 2001
1342001
Pre-steady state kinetic analysis of an enzymatic reaction monitored by time-resolved electrospray ionization mass spectrometry
DL Zechel, L Konermann, SG Withers, DJ Douglas
Biochemistry 37 (21), 7664-7669, 1998
1321998
Thermal and transition-metal-catalyzed ring-opening polymerization (ROP) of [1] silaferrocenophanes with chlorine substituents at silicon: A route to tunable poly …
DL Zechel, KC Hultzsch, R Rulkens, D Balaishis, Y Ni, JK Pudelski, ...
Organometallics 15 (8), 1972-1978, 1996
1081996
Utilization of glyphosate as phosphate source: biochemistry and genetics of bacterial carbon-phosphorus lyase
B Hove-Jensen, DL Zechel, B Jochimsen
Microbiology and Molecular Biology Reviews 78 (1), 176-197, 2014
1072014
Understanding how diverse β-mannanases recognize heterogeneous substrates
LE Tailford, VMA Ducros, JE Flint, SM Roberts, C Morland, DL Zechel, ...
Biochemistry 48 (29), 7009-7018, 2009
992009
Chloramphenicol biosynthesis: the structure of CmlS, a flavin-dependent halogenase showing a covalent flavin–aspartate bond
K Podzelinska, R Latimer, A Bhattacharya, LC Vining, DL Zechel, Z Jia
Journal of molecular biology 397 (1), 316-331, 2010
912010
Direct observation of the protonation state of an imino sugar glycosidase inhibitor upon binding
A Varrot, CA Tarling, JM Macdonald, RV Stick, DL Zechel, SG Withers, ...
Journal of the American Chemical Society 125 (25), 7496-7497, 2003
902003
An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products
CW Johnston, MA Skinnider, MA Wyatt, X Li, MRM Ranieri, L Yang, ...
Nature communications 6 (1), 1-11, 2015
882015
Anatomy of glycosynthesis: structure and kinetics of the Humicola insolens Cel7B E197A and E197S glycosynthase mutants
VMA Ducros, CA Tarling, DL Zechel, AM Brzozowski, TP Frandsen, ...
Chemistry & biology 10 (7), 619-628, 2003
752003
Enzymatic synthesis of carbon− fluorine bonds
DL Zechel, SP Reid, O Nashiru, C Mayer, D Stoll, DL Jakeman, ...
Journal of the American Chemical Society 123 (18), 4350-4351, 2001
732001
Mechanism, mutagenesis, and chemical rescue of a β-mannosidase from Cellulomonas fimi
DL Zechel, SP Reid, D Stoll, O Nashiru, RAJ Warren, SG Withers
Biochemistry 42 (23), 7195-7204, 2003
702003
A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene
L Kalan, A Gessner, MN Thaker, N Waglechner, XM Zhu, A Szawiola, ...
Chemistry & biology 20 (10), 1214-1224, 2013
562013
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