Peter Leadlay
Peter Leadlay
Professor of Biochemistry, University of Cambridge
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An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea
J Cortes, SF Haydock, GA Roberts, DJ Bevitt, PF Leadlay
Nature 348 (6297), 176-178, 1990
How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 Å resolution
F Mancia, NH Keep, A Nakagawa, PF Leadlay, S McSweeney, ...
Structure 4 (3), 339-350, 1996
Combinatorial biosynthesis of reduced polyketides
KJ Weissman, PF Leadlay
Nature reviews microbiology 3 (12), 925-936, 2005
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338
M Oliynyk, M Samborskyy, JB Lester, T Mironenko, N Scott, S Dickens, ...
Nature biotechnology 25 (4), 447-453, 2007
Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans
TP Stinear, A Mve-Obiang, PLC Small, W Frigui, MJ Pryor, R Brosch, ...
Proceedings of the National Academy of Sciences 101 (5), 1345-1349, 2004
A chain initiation factor common to both modular and aromatic polyketide synthases
C Bisang, PF Long, J Corte, J Westcott, J Crosby, AL Matharu, RJ Cox, ...
Nature 401 (6752), 502-505, 1999
Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage
J Cortes, KE Wiesmann, GA Roberts, MJ Brown, J Staunton, PF Leadlay
Science 268 (5216), 1487-1489, 1995
Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of the enzymatic domains in the modular polyketide synthase
JF Aparicio, I Molnár, T Schwecke, A König, SF Haydock, LE Khaw, ...
Gene 169 (1), 9-16, 1996
Engineering broader specificity into an antibiotic-producing polyketide synthase
AFA Marsden, B Wilkinson, J Cortés, NJ Dunster, J Staunton, PF Leadlay
Science 279 (5348), 199-202, 1998
Divergent sequence motifs correlated with the substrate specificity of (methyl) malonyl‐CoA: acyl carrier protein transacylase domains in modular polyketide synthases
SF Haydock, JF Aparicio, I Molnár, T Schwecke, LE Khaw, A König, ...
FEBS letters 374 (2), 246-248, 1995
A hybrid modular polyketide synthase obtained by domain swapping
M Oliynyk, MJB Brown, J Cortés, J Staunton, PF Leadlay
Chemistry & biology 3 (10), 833-839, 1996
6‐Deoxyerythronolide‐B synthase 2 from Saccharopolyspora erythraea Cloning of the structural gene, sequence analysis and inferred domain structure of the …
European journal of biochemistry 204 (1), 39-49, 1992
The structure of docking domains in modular polyketide synthases
RW Broadhurst, D Nietlispach, MP Wheatcroft, PF Leadlay, KJ Weissman
Chemistry & biology 10 (8), 723-731, 2003
Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units
ML Heathcote, J Staunton, PF Leadlay
Chemistry & biology 8 (2), 207-220, 2001
Stereospecific acyl transfers on the erythromycin-producing polyketide synthase
AF Marsden, P Caffrey, JF Aparicio, MS Loughran, J Staunton, ...
Science 263 (5145), 378-380, 1994
Combinatorial approaches to polyketide biosynthesis
PF Leadlay
Current opinion in chemical biology 1 (2), 162-168, 1997
Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S …
SF Haydock, JA Dowson, N Dhillon, GA Roberts, J Cortes, PF Leadlay
Molecular and General Genetics MGG 230 (1), 120-128, 1991
Increasing the efficiency of heterologous promoters in actinomycetes
CJ Wilkinson, ZA Hughes-Thomas, CJ Martin, I Bohm, T Mironenko, ...
Journal of molecular microbiology and biotechnology 4 (4), 417-426, 2002
Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of genes flanking the polyketide synthase
I Molnár, JF Aparicio, SF Haydock, LE Khaw, T Schwecke, A König, ...
Gene 169 (1), 1-7, 1996
Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes …
M Oliynyk, CBW Stark, A Bhatt, MA Jones, ZA Hughes‐Thomas, ...
Molecular microbiology 49 (5), 1179-1190, 2003
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