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Kwok Ho Lam
Kwok Ho Lam
Assistant Project Scientist, University of California, Irvine
Verifisert e-postadresse på uci.edu
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Massively parallel de novo protein design for targeted therapeutics
A Chevalier, DA Silva, GJ Rocklin, DR Hicks, R Vergara, P Murapa, ...
Nature 550 (7674), 74-79, 2017
4202017
N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A
G Yao, S Zhang, S Mahrhold, K Lam, D Stern, K Bagramyan, K Perry, ...
Nature structural & molecular biology 23 (7), 656-662, 2016
1152016
Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B
P Chen, L Tao, T Wang, J Zhang, A He, K Lam, Z Liu, X He, K Perry, ...
Science 360 (6389), 664-669, 2018
1132018
Structure of the full-length Clostridium difficile toxin B
P Chen, K Lam, Z Liu, FA Mindlin, B Chen, CB Gutierrez, L Huang, ...
Nature structural & molecular biology 26 (8), 712-719, 2019
712019
Crystal structure of the SENP1 mutant C603S–SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease
Z Xu, SF Chau, KH Lam, HY Chan, TB Ng, SWN Au
Biochemical Journal 398 (3), 345-352, 2006
712006
Diverse binding modes, same goal: The receptor recognition mechanism of botulinum neurotoxin
KH Lam, G Yao, R Jin
Progress in biophysics and molecular biology 117 (2-3), 225-231, 2015
472015
Multiple conformations of the FliG C-terminal domain provide insight into flagellar motor switching
KH Lam, WS Ip, YW Lam, SO Chan, TKW Ling, SWN Au
Structure 20 (2), 315-325, 2012
472012
Structural basis of FliG–FliM interaction in Helicobacter pylori
KH Lam, WWL Lam, JYK Wong, LC Chan, M Kotaka, TKW Ling, DY Jin, ...
Molecular microbiology 88 (4), 798-812, 2013
452013
Architecture of the botulinum neurotoxin complex: a molecular machine for protection and delivery
KH Lam, R Jin
Current opinion in structural biology 31, 89-95, 2015
442015
Crystal structure of the FliF-FliG complex from Helicobacter pylori yields insight into the assembly of the motor MS-C ring in the bacterial flagellum
C Xue, KH Lam, H Zhang, K Sun, SH Lee, X Chen, SWN Au
Journal of biological chemistry, 2017
372017
SUMO proteases: redox regulation and biological consequences
Z Xu, HY Chan, WL Lam, KH Lam, LSM Lam, TB Ng, SWN Au
Antioxidants & Redox Signaling 11 (6), 1453-1484, 2009
362009
Structural basis of the pH-dependent assembly of a botulinum neurotoxin complex
T Matsui, S Gu, K Lam, LG Carter, A Rummel, II Mathews, R Jin
Journal of molecular biology 426 (22), 3773-3782, 2014
352014
A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1
K Lam, Z Guo, N Krez, T Matsui, K Perry, J Weisemann, A Rummel, ...
Nature communications 9 (1), 5367, 2018
342018
Crystal Structure of Activated CheY1 from Helicobacter pylori
KH Lam, TKW Ling, SWN Au
Journal of bacteriology 192 (9), 2324-2334, 2010
312010
Crystal structure of the receptor-binding domain of botulinum neurotoxin type HA, also known as type FA or H
G Yao, K Lam, K Perry, J Weisemann, A Rummel, R Jin
Toxins 9 (3), 93, 2017
302017
Structural insights into rational design of single-domain antibody-based antitoxins against botulinum neurotoxins
K Lam, JM Tremblay, E Vazquez-Cintron, K Perry, C Ondeck, RP Webb, ...
Cell reports 30 (8), 2526-2539. e6, 2020
292020
Botulinum neurotoxin A complex recognizes host carbohydrates through its hemagglutinin component
G Yao, K Lee, S Gu, KH Lam, R Jin
Toxins 6 (2), 624-635, 2014
252014
High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex
K Lee, KH Lam, AM Kruel, K Perry, A Rummel, R Jin
Biochemical and biophysical research communications 446 (2), 568-573, 2014
222014
The hypothetical protein P47 of Clostridium botulinum E1 strain Beluga has a structural topology similar to bactericidal/permeability-increasing protein
K Lam, R Qi, S Liu, A Kroh, G Yao, K Perry, A Rummel, R Jin
Toxicon 147, 19-26, 2018
192018
A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding
G Yao, K Lam, J Weisemann, L Peng, N Krez, K Perry, CB Shoemaker, ...
Scientific reports 7 (1), 7438, 2017
192017
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Artikler 1–20